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However, the relationship between osteosarcopenia and coronary artery disease is largely unexplored. We aimed to investigate the association between osteosarcopenia and coronary artery calcification (CAC) scores in asymptomatic adults. A total of 5969 asymptomatic adults without cardiovascular disease who underwent a health examination including estimation of CAC scores by cardiac tomography were analyzed. Osteoporosis was defined as low bone mineral density T-score\u2009\u2264\u2009\u2009\u2212\u20092.5 standard deviation, and sarcopenia as appendicular skeletal muscle mass\u2009&lt;\u20095.7\u00a0kg\/m<jats:sup>2<\/jats:sup> for women and\u2009&lt;\u20097.0\u00a0kg\/m<jats:sup>2<\/jats:sup> for men, and osteosarcopenia as the copresence of both osteoporosis and sarcopenia. Participants were divided into four groups according to the presence of osteoporosis and\/or sarcopenia as control, sarcopenia alone, osteoporosis alone, and osteosarcopenia. Prevalence of CAC was 22.0% in control, 23.6% in sarcopenia alone, 38.5% in osteoporosis alone, and 48.3% in osteosarcopenia group, with the osteosarcopenia group showing the highest (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). After adjustments for possible confounders, mean of log (CAC score\u2009+\u20091) in osteosarcopenia group was higher than other three groups (Bonferroni <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Using multivariate-adjusted analysis, subjects with osteosarcopenia had the highest risk for having CAC\u2009&gt;\u20090 (odds ratio [OR] 2.868; 95% confidence interval [CI] 1.717\u20134.790). Furthermore, subjects with osteosarcopenia had a significant risk of moderate-to-extensive CAC (CAC score\u2009\u2265\u2009100) (OR 2.709; 95% CI 1.128\u20136.505). We demonstrated that osteosarcopenia was independently associated with a higher prevalence of subclinical coronary atherosclerosis. Our results suggest osteosarcopenia as a predisposing factor for coronary heart disease.<\/jats:p>","DOI":"10.1038\/s41598-021-02640-1","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T10:04:51Z","timestamp":1649066691000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association between osteosarcopenia and coronary artery calcification in asymptomatic individuals"],"prefix":"10.1038","volume":"12","author":[{"given":"Chul-Hyun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Taek","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Jae","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"2640_CR1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1093\/rheumatology\/keaa755","volume":"60","author":"MA Clynes","year":"2021","unstructured":"Clynes, M. 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