{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:00:30Z","timestamp":1772136030985,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"Abstract<\/jats:title>\n \n The paper has aimed at studying the transfer of indole 3-acetic acid (\n IAA<\/jats:italic>\n ) from a feed aqueous solution to a stripping aqueous solution of\n NaOH<\/jats:italic>\n using a chloroform bulk liquid membrane and trioctylamine (\n TOA<\/jats:italic>\n ) as a ligand (\n L<\/jats:italic>\n ). Initial molar concentrations of\n IAA<\/jats:italic>\n in the feed phase,\n c<\/jats:italic>\n \n IAA,F<\/jats:italic>\n 0\n <\/jats:sub>\n (10\n \u20134<\/jats:sup>\n \u201310\n \u20133\u00a0<\/jats:sup>\n kmol\/m\n 3<\/jats:sup>\n ), of\n TOA<\/jats:italic>\n in the membrane phase,\n c<\/jats:italic>\n \n L,M<\/jats:italic>\n 0\n <\/jats:sub>\n (10\n \u20132<\/jats:sup>\n and 10\n \u20131<\/jats:sup>\n kmol\/m\n 3<\/jats:sup>\n ), and of\n NaOH<\/jats:italic>\n in the stripping phase,\n c<\/jats:italic>\n \n NaOH,S<\/jats:italic>\n 0\n <\/jats:sub>\n (10\n \u20132<\/jats:sup>\n and 1 kmol\/m\n 3<\/jats:sup>\n ), were selected as process factors. Their effects on the final values of\n IAA<\/jats:italic>\n concentration in the feed phase (\n c<\/jats:italic>\n \n IAA,Ff<\/jats:italic>\n <\/jats:sub>\n ) and stripping solution (\n c<\/jats:italic>\n \n IAA,Sf<\/jats:italic>\n <\/jats:sub>\n ), extraction efficiency (\n E<\/jats:italic>\n \n F<\/jats:italic>\n <\/jats:sub>\n ), distribution coefficient (\n K<\/jats:italic>\n \n D<\/jats:italic>\n <\/jats:sub>\n ), and recovery efficiency (\n E<\/jats:italic>\n \n R<\/jats:italic>\n <\/jats:sub>\n ) were quantified using multiple regression equations. Regression coefficients were determined from experimental data, i.e\n .<\/jats:italic>\n ,\n c<\/jats:italic>\n \n IAA,Ff,ex<\/jats:italic>\n <\/jats:sub>\n \u2009=\u20090.02\u20131\u2009\u00d7\u200910\n \u20134<\/jats:sup>\n kmol\/m\n 3<\/jats:sup>\n ,\n c<\/jats:italic>\n \n IAA,Sf,ex<\/jats:italic>\n <\/jats:sub>\n \u2009=\u20090.22\u20132.58\u2009\u00d7\u200910\n \u20133<\/jats:sup>\n kmol\/m\n 3<\/jats:sup>\n ,\n E<\/jats:italic>\n \n F,ex<\/jats:italic>\n <\/jats:sub>\n \u2009=\u200990.0\u201397.9%,\n K<\/jats:italic>\n \n D,ex<\/jats:italic>\n <\/jats:sub>\n \u2009=\u20099.0\u201346.6, and\n E<\/jats:italic>\n \n R,ex<\/jats:italic>\n <\/jats:sub>\n \u2009=\u200966.5\u201394.2%. It was found that\n c<\/jats:italic>\n \n IAA,F<\/jats:italic>\n 0\n <\/jats:sub>\n had the most significant positive effect on\n c<\/jats:italic>\n \n IAA,Ff<\/jats:italic>\n <\/jats:sub>\n and\n c<\/jats:italic>\n \n IAA,Sf<\/jats:italic>\n <\/jats:sub>\n , whereas\n c<\/jats:italic>\n \n NaOH,S<\/jats:italic>\n 0\n <\/jats:sub>\n had a major positive effect on\n E<\/jats:italic>\n \n F<\/jats:italic>\n <\/jats:sub>\n ,\n K<\/jats:italic>\n \n D<\/jats:italic>\n <\/jats:sub>\n , and\n E<\/jats:italic>\n \n R<\/jats:italic>\n <\/jats:sub>\n . A deterministic model based on mass transfer of\n IAA<\/jats:italic>\n was developed and its parameters, i.e\n .<\/jats:italic>\n , mass transfer coefficient of\n IAA-L<\/jats:italic>\n complex in the liquid membrane (0.82\u201311.5\u2009\u00d7\u200910\n \u20137<\/jats:sup>\n \u00a0m\/s) and extraction constant (1033.9\u20131779.7\u00a0m\n 3<\/jats:sup>\n \/kmol), were regressed from experimental data. The effect of\n c<\/jats:italic>\n \n L,M<\/jats:italic>\n 0\n <\/jats:sub>\n on both parameters was significant.\n <\/jats:p>","DOI":"10.1038\/s41598-021-02876-x","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T06:06:05Z","timestamp":1638770765000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of process factors on performances of liquid membrane-based transfer of indole-3-acetic acid"],"prefix":"10.1038","volume":"11","author":[{"given":"Ioana","family":"Diaconu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana Cristina","family":"P\u00e2rvulescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorina Laura","family":"Topal\u0103","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u0103nase","family":"Dobre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"2876_CR1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.microc.2016.04.014","volume":"128","author":"B Campanella","year":"2016","unstructured":"Campanella, B. et al. New polymeric sorbent for the solid-phase extraction of indole-3-acetic acid from plants followed by liquid chromatography\u2212Fluorescence detector. Microchem. J. 128, 68\u201374 (2016).","journal-title":"Microchem. J."},{"issue":"4","key":"2876_CR2","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1007\/s00216-012-6509-2","volume":"405","author":"S Liu","year":"2013","unstructured":"Liu, S., Chen, W., Qu, L., Gai, Y. & Jiang, X. Simultaneous determination of 24 or more acidic and alkaline phytohormones in femtomole quantities of plant tissues by high-performance liquid chromatography\u2013electrospray ionization\u2013ion trap mass spectrometry. Anal. Bioanal. Chem. 405(4), 1257\u20131266 (2013).","journal-title":"Anal. Bioanal. Chem."},{"issue":"10","key":"2876_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076559","volume":"8","author":"AJ Donati","year":"2013","unstructured":"Donati, A. J., Lee, H. I., Leveau, J. H. & Chang, W. S. Effects of indole-3-acetic acid on the transcriptional activities and stress tolerance of Bradyrhizobium japonicum. PLoS ONE 8(10), e76559. https:\/\/doi.org\/10.1371\/journal.pone.0076559 (2013).","journal-title":"PLoS ONE"},{"key":"2876_CR4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.micres.2018.08.004","volume":"216","author":"HR Lin","year":"2018","unstructured":"Lin, H. R., Shu, H. Y. & Lin, G. H. Biological roles of indole-3-acetic acid in Acinetobacter baumannii. Microbiol. Res. 216, 30\u201339 (2018).","journal-title":"Microbiol. Res."},{"key":"2876_CR5","doi-asserted-by":"publisher","first-page":"101435","DOI":"10.1016\/j.bcab.2019.101435","volume":"23","author":"KS Rupal","year":"2020","unstructured":"Rupal, K. S., Raval, V. H. & Saraf, M. Biosynthesis and purification of indole-3-acetic acid by halotolerant rhizobacteria isolated from Little Runn of Kachchh. Biocatal. Agric. Biotechnol. 23, 101435. https:\/\/doi.org\/10.1016\/j.bcab.2019.101435 (2020).","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"2876_CR6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jchromb.2015.11.047","volume":"1009","author":"L Sheikhian","year":"2016","unstructured":"Sheikhian, L. & Bina, S. Simultaneous extraction and HPLC determination of 3-indole butyric acid and 3-indole acetic acid in pea plant by using ionic liquid-modified silica as sorbent. J. Chromatogr. B 1009, 34\u201343 (2016).","journal-title":"J. Chromatogr. B"},{"issue":"3","key":"2876_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2021.103814","volume":"172","author":"D Torres","year":"2021","unstructured":"Torres, D. et al. Molecular and physiological analysis of indole-3-acetic acid degradation in Bradyrhizobium japonicum E109. Res. Microbiol. 172(3), 103814. https:\/\/doi.org\/10.1016\/j.resmic.2021.103814 (2021).","journal-title":"Res. Microbiol."},{"issue":"7","key":"2876_CR8","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1365\/s10337-007-0350-3","volume":"66","author":"HT Liu","year":"2007","unstructured":"Liu, H. T., Li, Y. F., Luan, T. G., Lan, C. Y. & Shu, W. S. Simultaneous determination of phytohormones in plant extracts using SPME and HPLC. Chromatographia 66(7), 515\u2013520 (2007).","journal-title":"Chromatographia"},{"issue":"45","key":"2876_CR9","doi-asserted-by":"publisher","first-page":"7657","DOI":"10.1016\/j.chroma.2009.09.008","volume":"1216","author":"Y Wu","year":"2009","unstructured":"Wu, Y. & Hu, B. Simultaneous determination of several phytohormones in natural coconut juice by hollow fiber-based liquid\u2013liquid\u2013liquid microextraction-high performance liquid chromatography. J. Chromatogr. A 1216(45), 7657\u20137663 (2009).","journal-title":"J. Chromatogr. A"},{"issue":"6","key":"2876_CR10","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1021\/acs.jced.0c00137","volume":"65","author":"N Baylan","year":"2020","unstructured":"Baylan, N. Imidazolium-based ionic liquids for acrylic acid separation from water by bulk liquid membrane and extraction methods: A comparison study. J. Chem. Eng. Data 65(6), 3121\u20133129 (2020).","journal-title":"J. Chem. Eng. Data"},{"key":"2876_CR11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.molliq.2018.06.075","volume":"266","author":"N Baylan","year":"2018","unstructured":"Baylan, N. & \u00c7ehreli, S. Ionic liquids as bulk liquid membranes on levulinic acid removal: A design study. J. Mol. Liq. 266, 299\u2013308 (2018).","journal-title":"J. Mol. Liq."},{"issue":"6","key":"2876_CR12","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1080\/01932691.2016.1214841","volume":"38","author":"N Baylan","year":"2017","unstructured":"Baylan, N., \u00c7ehreli, S. & \u00d6zparlak, N. Transport and separation of carboxylic acids through bulk liquid membranes containing tributylamine. J. Dispers. Sci. Technol. 38(6), 895\u2013900 (2017).","journal-title":"J. Dispers. Sci. Technol."},{"key":"2876_CR13","first-page":"133","volume":"17","author":"A Kaur","year":"2010","unstructured":"Kaur, A. & Vohra, D. Study of bulk liquid membrane as a separation technique to recover acetic and propionic acids from dilute solutions. Indian J. Chem. Technol. 17, 133\u2013138 (2010).","journal-title":"Indian J. Chem. Technol."},{"key":"2876_CR14","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.cherd.2018.07.038","volume":"137","author":"E Reyhanitash","year":"2018","unstructured":"Reyhanitash, E. et al. Liquid\u2013liquid extraction-based process concepts for recovery of carboxylic acids from aqueous streams evaluated for dilute streams. Chem. Eng. Res. Des. 137, 510\u2013533 (2018).","journal-title":"Chem. Eng. Res. Des."},{"issue":"38","key":"2876_CR15","doi-asserted-by":"publisher","first-page":"13506","DOI":"10.1002\/chem.201601920","volume":"22","author":"L Zeininger","year":"2016","unstructured":"Zeininger, L., Portilla, L., Halik, M. & Hirsch, A. Quantitative determination and comparison of the surface binding of phosphonic acid, carboxylic acid, and catechol ligands on TiO2 nanoparticles. Chem. Eur. J. 22(38), 13506\u201313512 (2016).","journal-title":"Chem. Eur. J."},{"issue":"4","key":"2876_CR16","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1039\/C8EW00007G","volume":"4","author":"X Zhang","year":"2018","unstructured":"Zhang, X., Scott, J., Sharma, B. K. & Rajagopalan, N. Advanced treatment of hydrothermal liquefaction wastewater with nanofiltration to recover carboxylic acids. Environ. Sci. Water Res. Technol. 4(4), 520\u2013528 (2018).","journal-title":"Environ. Sci. Water Res. Technol."},{"key":"2876_CR17","doi-asserted-by":"publisher","first-page":"13868","DOI":"10.1038\/s41598-020-70968-11-8","volume":"10","author":"FJ Alguacil","year":"2020","unstructured":"Alguacil, F. J. & L\u00f3pez, F. A. Dispersion-free extraction of In (III) from HCl solutions using a supported liquid membrane containing the HA324H+Cl\u2212 ionic liquid as the carrier. Sci. Rep. 10, 13868. https:\/\/doi.org\/10.1038\/s41598-020-70968-11-8 (2020).","journal-title":"Sci. Rep."},{"key":"2876_CR18","doi-asserted-by":"publisher","first-page":"113828","DOI":"10.1016\/j.indcrop.2021.113828","volume":"170","author":"ID Boateng","year":"2021","unstructured":"Boateng, I. D., Soetanto, D. A., Li, F., Yang, X. M. & Li, Y. Y. Separation and purification of polyprenols from Ginkgo biloba L. leaves by bulk ionic liquid membrane and optimizing parameters. Ind. Crops Prod. 170, 113828. https:\/\/doi.org\/10.1016\/j.indcrop.2021.113828 (2021).","journal-title":"Ind. Crops Prod."},{"key":"2876_CR19","volume-title":"Liquid Membranes: Principles and Applications in Chemical Separations and Wastewater Treatment","year":"2009","unstructured":"Kislik, V. S. (ed.) Liquid Membranes: Principles and Applications in Chemical Separations and Wastewater Treatment (Elsevier, 2009)."},{"issue":"11","key":"2876_CR20","doi-asserted-by":"publisher","first-page":"5851","DOI":"10.1007\/s13369-017-3039-4","volume":"43","author":"AA Mohammed","year":"2018","unstructured":"Mohammed, A. A., Hussein, M. A. & Albdiri, A. D. Application of bulk liquid membrane technique for cadmium extraction from aqueous solution. Arab. J. Sci. Eng. 43(11), 5851\u20135858 (2018).","journal-title":"Arab. J. Sci. Eng."},{"issue":"12","key":"2876_CR21","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1134\/S0036024419120264","volume":"93","author":"S Akbari","year":"2019","unstructured":"Akbari, S., Khoshnood, R. S. & Pourayoubi, M. Separation\/competitive transport of heavy metal ions across the bulk liquid membranes with N, N\u2019, N\u2019\u2019-Tris (4-methylphenyl) phosphoric triamide as carrier. Russ. J. Phys. Chem. A 93(12), 2472\u20132476 (2019).","journal-title":"Russ. J. Phys. Chem. A"},{"key":"2876_CR22","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.seppur.2017.12.053","volume":"197","author":"L Chen","year":"2018","unstructured":"Chen, L. et al. An overview on membrane strategies for rare earths extraction and separation. Sep. Purif. Technol. 197, 70\u201385 (2018).","journal-title":"Sep. Purif. Technol."},{"issue":"4","key":"2876_CR23","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1080\/10408347.2015.1064759","volume":"46","author":"I Diaconu","year":"2016","unstructured":"Diaconu, I., Ruse, E., Aboul-Enein, H. Y. & Bunaciu, A. A. Analytical applications of transport through bulk liquid membranes. Crit. Rev. Anal. Chem. 46(4), 332\u2013341 (2016).","journal-title":"Crit. Rev. Anal. Chem."},{"key":"2876_CR24","doi-asserted-by":"publisher","first-page":"120145","DOI":"10.1016\/j.talanta.2019.120145","volume":"206","author":"F Tajabadi","year":"2020","unstructured":"Tajabadi, F. & Ghambarian, M. Carrier-mediated extraction: Applications in extraction and microextraction methods. Talanta 206, 120145. https:\/\/doi.org\/10.1016\/j.talanta.2019.120145 (2020).","journal-title":"Talanta"},{"issue":"2","key":"2876_CR25","first-page":"3386","volume":"25","author":"N Joshi","year":"2021","unstructured":"Joshi, N., Keshav, A., Khapre, A. & Poonia, A. K. Separation of butyric acid through agitated bulk liquid membrane. Ann. R.S.C.B. 25(2), 3386\u20133391 (2021).","journal-title":"Ann. R.S.C.B."},{"key":"2876_CR26","first-page":"68","volume":"28","author":"S Tarahomi","year":"2017","unstructured":"Tarahomi, S., Rounaghi, G. H., Eshghi, H., Daneshvar, L. & Chamsaz, M. Selective transport of silver (I) cation across a bulk liquid membrane containing bis-\u03b2-enamino ester as ion carrier. J. Braz. Chem. Soc. 28, 68\u201375 (2017).","journal-title":"J. Braz. Chem. Soc."},{"issue":"1","key":"2876_CR27","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/membranes11010020","volume":"11","author":"S Pav\u00f3n","year":"2021","unstructured":"Pav\u00f3n, S., Blaesing, L., Jahn, A., Aubel, I. & Bertau, M. Liquid membranes for efficient recovery of phenolic compounds such as vanillin and catechol. Membranes 11(1), 20. https:\/\/doi.org\/10.3390\/membranes11010020 (2021).","journal-title":"Membranes"},{"issue":"6","key":"2876_CR28","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1021\/es00055a018","volume":"28","author":"B Raghuraman","year":"1994","unstructured":"Raghuraman, B., Tirmizi, N. & Wiencek, J. Emulsion liquid membranes for wastewater treatment: Equilibrium models for some typical metal-extractant systems. Environ. Sci. Technol. 28(6), 1090\u20131098 (1994).","journal-title":"Environ. Sci. Technol."},{"key":"2876_CR29","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/(SICI)1521-4125(200001)23:1<70::AID-CEAT70>3.0.CO;2-O","volume":"23","author":"M Jung","year":"2000","unstructured":"Jung, M., Schierbaum, B. & Vogel, H. Extraction of carboxylic acids from aqueous solutions with the extractant system alcohol\/trin-alkylamines. Chem. Eng. Technol. 23, 70\u201374 (2000).","journal-title":"Chem. Eng. Technol."},{"key":"2876_CR30","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jiec.2018.06.021","volume":"67","author":"V Kumar","year":"2018","unstructured":"Kumar, V., Raghubansh, K. S. & Chowdhury, P. Efficient extraction and recovery of Lignosulfonate using sunflower oil as green solvent in liquid membrane transport: Equilibrium and kinetic study. J. Ind. Eng. Chem. 67, 109\u2013122 (2018).","journal-title":"J. Ind. Eng. Chem."},{"key":"2876_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ces.2019.02.017","volume":"201","author":"L Zeng","year":"2019","unstructured":"Zeng, L., Liu, Q., Luo, L., Liu, L. & Tang, K. Enhancement mechanism of an improved liquid membrane using selective permeation retardant for heavy metal ions separation. Chem. Eng. Sci. 201, 1\u201314 (2019).","journal-title":"Chem. Eng. Sci."},{"issue":"8","key":"2876_CR32","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.37358\/RC.19.8.7414","volume":"70","author":"I Diaconu","year":"2019","unstructured":"Diaconu, I., Serban, E. A., Badea, G. I. & Ruse, E. Transport of indole 3-acetic acid through bulk liquid membrane: Influence of carrier in the diffusion process. Rev. Chim. 70(8), 2716\u20132719 (2019).","journal-title":"Rev. Chim."},{"issue":"1","key":"2876_CR33","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.arabjc.2010.06.025","volume":"4","author":"I Diaconu","year":"2011","unstructured":"Diaconu, I. et al. Separation of nitrophenols: Equilibriums in bi- and tri-phasic systems. Arab. J. Chem. 4(1), 99\u2013103 (2011).","journal-title":"Arab. J. Chem."},{"key":"2876_CR34","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s13738-013-0245-1","volume":"10","author":"I Zaharia","year":"2013","unstructured":"Zaharia, I. et al. Facilitated transport of 5-aminosalicylic acid through bulk liquid membrane. J. Iran. Chem. Soc. 10, 1129\u20131136 (2013).","journal-title":"J. Iran. Chem. Soc."},{"key":"2876_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/9783527611096","volume-title":"Chemical Engineering: Modelling, Simulation, and Similitude","author":"T Dobre","year":"2007","unstructured":"Dobre, T. & Sanchez Marcano, J. Chemical Engineering: Modelling, Simulation, and Similitude (Wiley, 2007)."},{"key":"2876_CR36","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.apsusc.2015.02.040","volume":"335","author":"VA Ion","year":"2015","unstructured":"Ion, V. A., P\u00e2rvulescu, O. C. & Dobre, T. Volatile organic compounds adsorption onto neat and hybrid cellulose. Appl. Surf. Sci. 335, 137\u2013146 (2015).","journal-title":"Appl. Surf. Sci."},{"key":"2876_CR37","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1080\/01496395.2012.659316","volume":"47","author":"P Szczepa\u0144ski","year":"2012","unstructured":"Szczepa\u0144ski, P. & Diaconu, I. Transport of p-nitrophenol through an agitated bulk liquid. Sep. Sci. Technol. 47, 1725\u20131732 (2012).","journal-title":"Sep. Sci. Technol."}],"updated-by":[{"DOI":"10.1038\/s41598-022-05212-z","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-02876-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-02876-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-02876-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T13:12:25Z","timestamp":1670073145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-02876-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,6]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["2876"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-02876-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-923386\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,6]]},"assertion":[{"value":"20 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-022-05212-z","URL":"https:\/\/doi.org\/10.1038\/s41598-022-05212-z","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23427"}}