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The homogeneity of synthesized compounds was confirmed by melting point and thin layer chromatography. The synthesized compounds were characterized by using\n                    <jats:sup>1<\/jats:sup>\n                    H NMR, FTIR and CHN analyses and evaluated for in vitro herbicidal activity against\n                    <jats:italic>Raphanus sativus<\/jats:italic>\n                    L. (Radish seeds). The compounds\n                    <jats:bold>(4a\u20134h)<\/jats:bold>\n                    were also screened for their fungicidal activity against\n                    <jats:italic>Rhizoctonia solani<\/jats:italic>\n                    and\n                    <jats:italic>Colletotrichum gloeosporioides<\/jats:italic>\n                    . Antibacterial activity was also tested against\n                    <jats:italic>Erwinia carotovora<\/jats:italic>\n                    and\n                    <jats:italic>Xanthomonas citri<\/jats:italic>\n                    . From bio-evaluation data, it was found that compound\n                    <jats:bold>4b<\/jats:bold>\n                    was most active against\n                    <jats:italic>Raphanus sativus<\/jats:italic>\n                    L. (root) and\n                    <jats:italic>Raphanus sativus<\/jats:italic>\n                    L. (shoot) respectively. Compound\n                    <jats:bold>4b<\/jats:bold>\n                    was also found most active against both the fungus viz.\n                    <jats:italic>R. solani<\/jats:italic>\n                    and\n                    <jats:italic>C. gloeosporioides<\/jats:italic>\n                    showing maximum percentage growth inhibition i.e. 90.00 against\n                    <jats:italic>R. solani<\/jats:italic>\n                    and 82.45 against\n                    <jats:italic>C. gloeosporioides<\/jats:italic>\n                    at 2000\u00a0\u00b5g\/mL concentration. Compound 4\u00a0h has shown maximum inhibition zone i.e. 3.00\u20139.60\u00a0mm against\n                    <jats:italic>Erwinia carotovora<\/jats:italic>\n                    at 2000\u00a0\u00b5g\/mL concentration. Maximum\n                    <jats:italic>Xanthomonas citri<\/jats:italic>\n                    growth was also inhibited by compound 4\u00a0h showing inhibition zone 1.00\u20135.00\u00a0mm at highest concentration.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-03057-6","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T06:02:38Z","timestamp":1638856958000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Fruit juice mediated multicomponent reaction for the synthesis of substituted isoxazoles and their in vitro bio-evaluation"],"prefix":"10.1038","volume":"11","author":[{"given":"Susheel","family":"Gulati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajvir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Sangwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"3057_CR1","doi-asserted-by":"publisher","DOI":"10.1039\/9781847559760","volume-title":"Eco-Friendly Synthesis of Fine Chemicals","author":"R Balini","year":"2009","unstructured":"Balini, R. 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