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Several factors, including the pharmacogenetics of asparaginase and anthracyclines, could contribute to difference in treatment outcome in ALL. We investigated the significance of variations in genes involved in hepatic and cardiac toxicity in acute lymphoblastic leukemia (ALL). Genotyping of <jats:italic>SOD2<\/jats:italic> (rs4880), <jats:italic>PNPL3<\/jats:italic> (rs738409) and <jats:italic>ABCC1<\/jats:italic> (rs4148350), C<jats:italic>BR1<\/jats:italic> (rs9024) and <jats:italic>ABCG2<\/jats:italic> (rs2231142) was performed by Tetra-ARMS PCR-based technique to evaluate the genotype\u2013phenotype correlation. Our results showed only minor allele G of <jats:italic>SOD2<\/jats:italic> rs4880 increase the risk of hepatic toxicity [OR\u20092.63 (1.42\u20134.84), <jats:italic>P<\/jats:italic>\u2009=\u2009\u2009&lt;\u20090.05] while minor alleles of other SNPs showed protective impact. However, the genetic contrast analysis showed a recessive form of <jats:italic>SOD2<\/jats:italic> rs4880 [OR\u20097.82 (3.86\u201315.85), <jats:italic>P<\/jats:italic>\u2009=\u2009\u2009&lt;\u20090.05] and <jats:italic>PNPLA3<\/jats:italic> I148M [OR\u20095.82 (3.43\u20139.87), <jats:italic>P<\/jats:italic>\u2009=\u2009\u2009&lt;\u20090.05] variants whereas dominant genotype of <jats:italic>ABCC1<\/jats:italic> rs4148350 [OR\u20092.52 (1.55\u20134.10), <jats:italic>P<\/jats:italic>\u2009=\u2009\u2009&lt;\u20090.05] significantly predisposes hepatotoxicity. Furthermore, heterozygous form of <jats:italic>ABCG2<\/jats:italic> rs2231142 [OR\u20095.25 (1.84\u201314.95), <jats:italic>P<\/jats:italic>\u2009=\u2009\u2009&lt;\u20090.05] and recessive genotype of 3\u2032UTR variant <jats:italic>CBR1<\/jats:italic> rs9024 [OR\u20092.31 (1.31\u20134.07), <jats:italic>P<\/jats:italic>\u2009=\u2009\u2009&lt;\u20090.05] were strongly associated with cardiotoxicity. The information obtained from these genetic variations could offer biomarkers for individualization of therapeutic intervention in ALL.<\/jats:p>","DOI":"10.1038\/s41598-021-03208-9","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T11:12:09Z","timestamp":1639048329000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pharmacogenetics of induction therapy-related toxicities in childhood acute lymphoblastic leukemia patients treated with UKALL 2003 protocol"],"prefix":"10.1038","volume":"11","author":[{"given":"Sara","family":"Aslam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Ameer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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