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Although highly similar genotypically, the ecological niches of these three species are mutually exclusive, which raises the untested hypothesis that their metabolism has speciated along a nutritional tract. Here, we developed a pipeline for quantitative total assessment of the use of diverse sources of carbon for general metabolism to better appreciate the \u201cculinary preferences\u201d of three distinct\n                    <jats:italic>Bacillus<\/jats:italic>\n                    species, as well as related\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . We show that each species has widely varying metabolic ability to utilize diverse sources of carbon that correlated to their ecological niches. This approach was applied to the growth and survival of\n                    <jats:italic>B. anthracis<\/jats:italic>\n                    in a blood-like environment and find metabolism shifts from sugar to amino acids as the preferred source of energy. Finally, various nutrients in broth and host-like environments are identified that may promote or interfere with bacterial metabolism during infection.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-03420-7","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T06:04:31Z","timestamp":1639375471000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Metabolic profiling reveals nutrient preferences during carbon utilization in Bacillus species"],"prefix":"10.1038","volume":"11","author":[{"given":"James D.","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen E.","family":"Vaughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Gu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Jelinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austen L.","family":"Terwilliger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony W.","family":"Maresso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"3420_CR1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.tim.2011.04.003","volume":"19","author":"L Rohmer","year":"2011","unstructured":"Rohmer, L., Hocquet, D. & Miller, S. 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