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The aim of this study was to evaluate genetic variants previously associated with fatty liver as potential modulators of the AIH phenotype. The study cohort comprised 313 non-transplanted adults with AIH. In all patients, the <jats:italic>MARC1<\/jats:italic> (rs2642438), <jats:italic>HSD17B13<\/jats:italic> (rs72613567), <jats:italic>PNPLA3<\/jats:italic> (rs738409), <jats:italic>TM6SF2<\/jats:italic> (rs58542926), and <jats:italic>MBOAT7<\/jats:italic> (rs641738) variants were genotyped using TaqMan assays. Mitochondrial damage markers in serum were analyzed in relation to the <jats:italic>MARC1<\/jats:italic> variant. Carriers of the protective <jats:italic>MARC1<\/jats:italic> allele had lower ALT and AST (both P\u2009&lt;\u20090.05). In patients treated for AIH for\u2009\u2265\u20096\u00a0months, <jats:italic>MARC1<\/jats:italic> correlated with reduced AST, ALP, GGT (all P\u2009\u2264\u20090.01), and lower APRI (P\u2009=\u20090.02). Patients carrying the protective <jats:italic>MARC1<\/jats:italic> genotype had higher total antioxidant\u00a0activity (P\u2009&lt;\u20090.01) and catalase levels (P\u2009=\u20090.02) in serum. The <jats:italic>PNPLA3<\/jats:italic> risk variant was associated with higher MELD (P\u2009=\u20090.02) in treated patients, whereas <jats:italic>MBOAT7<\/jats:italic> increased the odds for liver cancer (OR\u2009=\u20093.71). None of the variants modulated the risk of death or transplantation. In conclusion, the <jats:italic>MARC1<\/jats:italic> polymorphism has protective effects in AIH. Genotyping of <jats:italic>MARC1<\/jats:italic>, <jats:italic>PNPLA3,<\/jats:italic> and <jats:italic>MBOAT7<\/jats:italic> polymorphisms might help to stratify patients with AIH.<\/jats:p>","DOI":"10.1038\/s41598-021-03521-3","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T11:03:57Z","timestamp":1640257437000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["MARC1 p.A165T variant is associated with decreased markers of liver injury and enhanced antioxidant capacity in autoimmune hepatitis"],"prefix":"10.1038","volume":"11","author":[{"given":"Maciej K.","family":"Janik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiktor","family":"Smyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Kruk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedykt","family":"Szczepankiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"G\u00f3rnicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Lebiedzi\u0144ska-Arciszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaiza","family":"Potes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas C. 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