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This study evaluates the real-world performance of the BioFire FilmArray Pneumonia panel <jats:italic>plus<\/jats:italic> (FAP <jats:italic>plus<\/jats:italic>) and explores the feasibility of evaluation in a randomised controlled trial. Patients presenting to hospital with suspected CAP were recruited in a prospective feasibility study. An induced sputum or an endotracheal aspirate was obtained from all participants. The FAP <jats:italic>plus<\/jats:italic> turnaround time (TAT) and microbiological yield were compared with standard diagnostic methods (SDs). 96\/104 (92%) enrolled patients had a respiratory tract infection (RTI); 72 CAP and 24 other RTIs. Median TAT was shorter for the\u00a0FAP <jats:italic>plus<\/jats:italic>, compared with in-house PCR (2.6 vs 24.1\u00a0h, p\u2009&lt;\u20090.001) and sputum cultures (2.6 vs 57.5\u00a0h, p\u2009&lt;\u20090.001). The total microbiological yield by the FAP <jats:italic>plus<\/jats:italic> was higher compared to SDs (91% (162\/179) vs 55% (99\/179), p\u2009&lt;\u20090.0001). <jats:italic>Haemophilus influenzae<\/jats:italic>, <jats:italic>Streptococcus pneumoniae<\/jats:italic> and influenza A virus were the most frequent pathogens. In conclusion,\u00a0molecular panel testing in adults with CAP was associated with a significant reduction in time to actionable results and increased microbiological yield. The impact on antibiotic use and patient outcome should be assessed in randomised controlled trials.<\/jats:p>","DOI":"10.1038\/s41598-021-03741-7","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T11:04:32Z","timestamp":1641812672000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Rapid syndromic PCR testing in patients with respiratory tract infections reduces time to results and improves microbial yield"],"prefix":"10.1038","volume":"12","author":[{"given":"S.","family":"Serigstad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Markussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M. 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