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Here the first bacteriocin of\n                    <jats:italic>Streptococcus anginosus<\/jats:italic>\n                    , designated Angicin, is described.\n                    <jats:italic>S. anginosus<\/jats:italic>\n                    is commonly described as a commensal, however it also possesses a high pathogenic potential. Therefore, understanding factors contributing to its host colonization and persistence are important. A radial diffusion assay was used to identify\n                    <jats:italic>S. anginosus<\/jats:italic>\n                    BSU 1211 as a potent bacteriocin producer. By genetic mutagenesis the background of bacteriocin production and the bacteriocin gene itself were identified. Synthetic Angicin shows high activity against closely related streptococci, listeria and vancomycin resistant enterococci. It has a fast mechanism of action and causes a membrane disruption in target cells. Angicin, present in cell free supernatant, is insensitive to changes in temperature from \u2212\u00a070 to 90\u00a0\u00b0C and pH values from 2 to 10, suggesting that it represents an interesting compound for potential applications in food preservation or clinical settings.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-03797-5","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T06:03:53Z","timestamp":1640066633000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Angicin, a novel bacteriocin of Streptococcus anginosus"],"prefix":"10.1038","volume":"11","author":[{"given":"Verena","family":"Vogel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Mauerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Schiffelholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Haupt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd M.","family":"Seibold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"F\u00e4ndrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Walther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Spellerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"3797_CR1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/jcp.32.8.764","volume":"32","author":"PM Poole","year":"1979","unstructured":"Poole, P. 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