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An online survey was distributed via social media between June and July 2020. The questionnaire elicited information on demographics, dry-eye symptoms, use of visual display terminals, and mental health status. There were 535 respondents. Thirty-seven percent reported having been diagnosed with dry-eye disease (DED). During the lockdown, the mean dry-eye symptom score (DESS) of overall participants dropped significantly from 81.6\u2009\u00b1\u200915.9 to 79.8\u2009\u00b1\u200917.4 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The mean, daily, visual display terminal (VDT) usage increased from 10.55\u2009\u00b1\u20095.16 to 13.08\u2009\u00b1\u20095.65\u00a0h (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). A negative correlation between age and VDT usage was observed in both the normal and lockdown situations. One-quarter of all participants had an abnormal mental health status. The female gender (OR 1.86; 95% CI 1.14\u20133.04) and increased VDT usage during the lockdown (OR 5.68; 95% CI 3.49\u20139.23) were independently associated with worsening dry-eye symptoms. The lockdown measures abruptly altered the behaviors and lifestyles of the overall population. Excessive exposure to VDTs were associated with deteriorated dry-eye symptoms, and it possibly contributed to the increased DED incidence in the surveyed population.<\/jats:p>","DOI":"10.1038\/s41598-021-03887-4","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T11:02:55Z","timestamp":1640343775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Provocation of dry eye disease symptoms during COVID-19 lockdown"],"prefix":"10.1038","volume":"11","author":[{"given":"Nutnicha","family":"Neti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinnita","family":"Prabhasawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chareenun","family":"Chirapapaisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panotsom","family":"Ngowyutagon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,24]]},"reference":[{"key":"3887_CR1","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/S0140-6736(20)30185-9","volume":"395","author":"C Wang","year":"2020","unstructured":"Wang, C., Horby, P. 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