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While modern advances in deep learning made possible reaching new heights in terms of classification accuracy, no publicly available skin cancer detection software provide confidence estimates for these predictions. We present <jats:italic>DUNEScan<\/jats:italic> (Deep Uncertainty Estimation for Skin Cancer), a web server that performs an intuitive in-depth analysis of uncertainty in commonly used skin cancer classification models based on convolutional neural networks (CNNs). <jats:italic>DUNEScan<\/jats:italic> allows users to upload a skin lesion image, and quickly compares the mean and the variance estimates provided by a number of new and traditional CNN models. Moreover, our web server uses the Grad-CAM and UMAP algorithms to visualize the classification manifold for the user\u2019s input, hence providing crucial information about its closeness to skin lesion images \u00a0from the popular ISIC database. <jats:italic>DUNEScan<\/jats:italic> is freely available at: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.dunescan.org\">https:\/\/www.dunescan.org<\/jats:ext-link>.<\/jats:p>","DOI":"10.1038\/s41598-021-03889-2","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T11:03:34Z","timestamp":1641553414000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["DUNEScan: a web server for uncertainty estimation in skin cancer detection with deep neural networks"],"prefix":"10.1038","volume":"12","author":[{"given":"Bogdan","family":"Mazoure","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Mazoure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"B\u00e9dard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Makarenkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"3889_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel, R. 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