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The disease is typically treated with antibiotics as they used to effectively inhibit or kill\n                    <jats:italic>H. pylori<\/jats:italic>\n                    , thus reducing the incidence of gastric adenoma and cancer to significant extent.\n                    <jats:italic>H. pylori<\/jats:italic>\n                    , however, has developed drug resistance to many clinically used antibiotics over the years, highlighting the crisis of antibiotic failure during the\n                    <jats:italic>H. pylori<\/jats:italic>\n                    treatment. We report here that the fucoidan from\n                    <jats:italic>Sargassum hemiphyllum<\/jats:italic>\n                    can significantly reduce the infection of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    without developing to drug resistance. Fucoidan appears to be a strong anti-inflammation agent as manifested by the RAW264.7 cell model examination. Fucoidan can prohibit\n                    <jats:italic>H. pylori<\/jats:italic>\n                    adhesion to host cells, thereby reducing the infection rate by 60%, especially in post treatment in the AGS cell model assay. Mechanistically, fucoidan intervenes the adhesion of BabA and AlpA of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    significantly lowering the total count of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    and the level of IL-6 and TNF-\u03b1 in vivo. These results all converge on the same fact that fucoidan is an effective agent in a position to protect the stomach from the\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection by reducing both the total count and induced inflammation.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-04151-5","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T06:04:32Z","timestamp":1641794672000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Fucoidan from Sargassum hemiphyllum inhibits infection and inflammation of Helicobacter pylori"],"prefix":"10.1038","volume":"12","author":[{"given":"Bo-Rui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Lin","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Jer","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"4151_CR1","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1021\/jf405199w","volume":"62","author":"HL Huang","year":"2014","unstructured":"Huang, H. 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