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We included premature infants treated for ROP at a tertiary referral center between January 2006 and December 2019. Demographic and clinical data were collected from electronic medical records. Odds ratios (ORs) of oxygen care- and ROP treatment-related factors were calculated for ocular and neurological comorbidities 3\u00a0years after ROP treatment, after adjusting for potential confounders. ROP requiring treatment was detected in 171 eyes (88 infants). Laser treatment for ROP (OR\u2009=\u20094.73, 95% confidence interval [CI] 1.64\u201313.63) and duration of invasive ventilation (OR\u2009=\u20091.02, 95% CI 1.00\u20131.03) were associated with an increase in ocular comorbidities, along with a history of neonatal seizure (OR\u2009=\u200928.29, 95% CI 5.80\u2013137.95) and chorioamnionitis (OR\u2009=\u200932.13, 95% CI 5.47\u2013188.74). No oxygen care- or ROP treatment-related factors showed significant odds for neurological comorbidities. Shorter duration of invasive oxygen supply during neonatal care (less than 49 days) and anti-vascular endothelial growth factor injection as the primary treatment for ROP are less likely to cause ocular comorbidities. No association was identified between ROP treatment modalities and the risk of neurological comorbidities.<\/jats:p>","DOI":"10.1038\/s41598-021-04221-8","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T11:04:32Z","timestamp":1641812672000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Oxygen care and treatment of retinopathy of prematurity in ocular and neurological prognosis"],"prefix":"10.1038","volume":"12","author":[{"given":"Hyun Goo","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuna","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Seungkyu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"4221_CR1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/pr.2013.205","volume":"74","author":"H Blencowe","year":"2013","unstructured":"Blencowe, H., Lawn, J. E., Vazquez, T., Fielder, A. & Gilbert, C. Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010. Pediatr. Res. 74, 35\u201349. https:\/\/doi.org\/10.1038\/pr.2013.205 (2013).","journal-title":"Pediatr. Res."},{"key":"4221_CR2","first-page":"233","volume":"102","author":"WV Good","year":"2004","unstructured":"Good, W. V., Early Treatment for Retinopathy of Prematurity Cooperative, G. Final results of the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial. Trans. Am. Ophthalmol. Soc. 102, 233\u2013248 (2004) (discussion 248\u2013250).","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"4221_CR3","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1056\/NEJMoa1007374","volume":"364","author":"HA Mintz-Hittner","year":"2011","unstructured":"Mintz-Hittner, H. A., Kennedy, K. A. & Chuang, A. Z. Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity. N. Engl. J. 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