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In this study, four SMAs (L1-SMA, T12-erector spinae muscle areas, chest wall muscle area at carina level, pectoralis muscle area at aortic arch level) were segmented semi-automatically in 780 individuals taking concurrent chest and abdomen LDCT for healthcare screening. Four SMAs were compared to L3-SMA and annual changes were calculated from individuals with multiple examinations (n\u2009=\u2009101). Skeletal muscle index (SMI; SMA\/height\n                    <jats:sup>2<\/jats:sup>\n                    ) cut-off for sarcopenia was determined by lower 5th percentile of young individuals (age\u2009\u2264\u200940\u00a0years). L1-SMA showed the greatest correlation to L3-SMA (men, R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.7920; women, R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.7396), and the smallest annual changes (0.3300\u2009\u00b1\u20094.7365%) among four SMAs. L1-SMI cut-offs for determining sarcopenia were 39.2cm\n                    <jats:sup>2<\/jats:sup>\n                    \/m\n                    <jats:sup>2<\/jats:sup>\n                    in men, and 27.5cm\n                    <jats:sup>2<\/jats:sup>\n                    \/m\n                    <jats:sup>2<\/jats:sup>\n                    in women. Forty-six men (9.5%) and ten women (3.4%) were found to have sarcopenia using L1-SMI cut-offs. In conclusion, L1-SMA could be a reasonable substitute for L3-SMA in chest LDCT. Suggested L1-SMI cut-offs for sarcopenia were 39.2cm\n                    <jats:sup>2<\/jats:sup>\n                    \/m\n                    <jats:sup>2<\/jats:sup>\n                    for men and 27.5cm\n                    <jats:sup>2<\/jats:sup>\n                    \/m\n                    <jats:sup>2<\/jats:sup>\n                    for women in Asian.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-04492-1","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T06:04:32Z","timestamp":1641794672000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Validation for measurements of skeletal muscle areas using low-dose chest computed tomography"],"prefix":"10.1038","volume":"12","author":[{"given":"Woo Hyeon","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"4492_CR1","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1093\/ageing\/afz046","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft, A. 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