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Independent single nucleotide polymorphisms associated with the metabolic and lifestyle factors at the <jats:italic>p<\/jats:italic>\u2009&lt;\u20095\u2009\u00d7\u200910<jats:sup>\u20138<\/jats:sup> were selected as instrument variables. Summary-level data for senile cataract were obtained from the FinnGen consortium (20,157 cases and 154,905 non-cases) and UK Biobank study (6332 cases and 354,862 non-cases). Higher genetically predicted BMI and SBP and genetic predisposition to T2D and smoking initiation were associated with an increased risk of senile cataract. The combined odds ratios were 1.19 (95% confidence interval (CI) 1.09\u20131.29; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) per one standard deviation increase in BMI (~\u20094.8\u00a0kg\/m<jats:sup>2<\/jats:sup>), 1.13 (95% CI 1.04\u20131.23; <jats:italic>p<\/jats:italic>\u2009=\u20090.004) per 10\u00a0mmHg increase in SBP, 1.06 (95% CI 1.03\u20131.09; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) per one unit increase in log-transformed odds ratio of T2D, and 1.19 (95% CI 1.10\u20131.29; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) per one standard deviation increase in prevalence of smoking initiation. Genetically predicted coffee consumption showed a suggestive association with senile cataract (odds ratio per 50% increase, 1.18, 95% CI 1.00\u20131.40; <jats:italic>p<\/jats:italic>\u2009=\u20090.050). This study suggests causal roles of obesity, T2D, SBP and smoking in senile cataract.<\/jats:p>","DOI":"10.1038\/s41598-021-04515-x","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T11:04:32Z","timestamp":1641812672000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Metabolic and lifestyle factors in relation to senile cataract: a Mendelian randomization study"],"prefix":"10.1038","volume":"12","author":[{"given":"Shuai","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Wolk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna C.","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"4515_CR1","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1038\/s41433-020-0806-3","volume":"34","author":"H Hashemi","year":"2020","unstructured":"Hashemi, H. et al. 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