{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:19:17Z","timestamp":1789838357388,"version":"4.0.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Evaluation of interocular asymmetry of optical coherence tomography (OCT) parameters is important for the glaucoma and optic neuropathies. This study was performed to evaluate the interocular asymmetry of OCT parameters in healthy children and adolescents. The circumpapillary retinal nerve fiber layer (RNFL) thickness, optic nerve head (ONH) parameters, and macular ganglion cell-inner plexiform layer (GCIPL) thickness were measured in 620 eyes of 310 healthy children and adolescents using Cirrus HD-OCT. The interocular asymmetry (right eye\u2013left eye) in the OCT parameters was analyzed. The mean\u2009\u00b1\u2009standard deviation age was 10.3\u2009\u00b1\u20093.7\u00a0years (range 5\u201317). The right eyes showed thinner superior quadrant RNFL, thicker nasal and temporal quadrant RNFL, lesser rim and disc areas, and thinner average, superior, and superonasal GCIPL than the left eyes (P\u2009&lt;\u20090.05). The 2.5th and 97.5th percentile interocular difference tolerance limits were \u2212\u20099.0\u00a0\u03bcm and 11.0\u00a0\u03bcm for average RNFL thickness, \u2212\u20090.21 and 0.18 for average cup-to-disc ratio, and \u2212\u20094.0\u00a0\u03bcm and 4.0\u00a0\u03bcm for average GCIPL thickness, respectively. Interocular differences were found in RNFL thickness, ONH parameters, and GCIPL thickness in healthy children and adolescents. These findings should be considered when comparing OCT parameters between the right and left eyes.<\/jats:p>","DOI":"10.1038\/s41598-021-04563-3","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T06:03:33Z","timestamp":1642053813000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Interocular symmetry of optical coherence tomography parameters in healthy children and adolescents"],"prefix":"10.1038","volume":"12","author":[{"given":"Mi Yeon","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hoon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"4563_CR1","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.ajo.2014.10.032","volume":"159","author":"SY Lee","year":"2015","unstructured":"Lee, S. Y., Jeoung, J. W., Park, K. H. & Kim, D. M. Macular ganglion cell imaging study: Interocular symmetry of ganglion cell-inner plexiform layer thickness in normal healthy eyes. Am. J. Ophthalmol. 159, 315-323.e2 (2015).","journal-title":"Am. J. Ophthalmol."},{"key":"4563_CR2","doi-asserted-by":"publisher","first-page":"e0222347","DOI":"10.1371\/journal.pone.0222347","volume":"14","author":"A Casado","year":"2019","unstructured":"Casado, A. et al. Topographic correlation and asymmetry analysis of ganglion cell layer thinning and the retinal nerve fiber layer with localized visual field defects. PLoS ONE 14, e0222347 (2019).","journal-title":"PLoS ONE"},{"key":"4563_CR3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1097\/IJG.0000000000000080","volume":"25","author":"MG Field","year":"2016","unstructured":"Field, M. G. et al. Facilitating glaucoma diagnosis with intereye retinal nerve fiber layer asymmetry using spectral-domain optical coherence tomography. J. Glaucoma. 25, 167\u2013176 (2016).","journal-title":"J. Glaucoma."},{"key":"4563_CR4","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/j.ajo.2013.07.021","volume":"156","author":"I Altemir","year":"2013","unstructured":"Altemir, I. et al. Retinal asymmetry in children measured with optical coherence tomography. Am. J. Ophthalmol. 156, 1238-1243.e1 (2013).","journal-title":"Am. J. Ophthalmol."},{"key":"4563_CR5","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1136\/bjophthalmol-2013-304345","volume":"98","author":"C Al-Haddad","year":"2014","unstructured":"Al-Haddad, C., Antonios, R., Tamim, H. & Noureddin, B. Interocular symmetry in retinal and optic nerve parameters in children as measured by spectral domain optical coherence tomography. Br. J. Ophthalmol. 98, 502\u2013506 (2014).","journal-title":"Br. J. Ophthalmol."},{"key":"4563_CR6","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/IJG.0b013e318287ac2f","volume":"24","author":"JD Dalgliesh","year":"2015","unstructured":"Dalgliesh, J. D., Tariq, Y. M., Burlutsky, G. & Mitchell, P. Symmetry of retinal parameters measured by spectral-domain OCT in normal young adults. J. Glaucoma. 24, 20\u201324 (2015).","journal-title":"J. Glaucoma."},{"key":"4563_CR7","doi-asserted-by":"publisher","first-page":"955","DOI":"10.4103\/ijo.IJO_71_17","volume":"65","author":"N Pawar","year":"2017","unstructured":"Pawar, N., Maheshwari, D., Ravindran, M. & Ramakrishnan, R. Interocular symmetry of retinal nerve fiber layer and optic nerve head parameters measured by Cirrus high-definition optical coherence tomography in a normal pediatric population. Indian J. Ophthalmol. 65, 955\u2013962 (2017).","journal-title":"Indian J. Ophthalmol."},{"key":"4563_CR8","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1186\/s12886-018-0940-x","volume":"18","author":"E Larsson","year":"2018","unstructured":"Larsson, E., Molnar, A. & Holmstr\u00f6m, G. Repeatability, reproducibility and interocular difference in the assessments of optic nerve OCT in children\u2014A Swedish population-based study. BMC Ophthalmol. 18, 270 (2018).","journal-title":"BMC Ophthalmol."},{"key":"4563_CR9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1080\/01658107.2017.1349806","volume":"42","author":"O Yabas Kiziloglu","year":"2017","unstructured":"Yabas Kiziloglu, O., Toygar, O., Toygar, B. & Hacimustafaoglu, A. M. Optic nerve head parameters measured with spectral-domain optical coherence tomography in healthy Turkish children: Normal values, repeatability, and interocular symmetry. Neuroophthalmology. 42, 83\u201389 (2017).","journal-title":"Neuroophthalmology."},{"key":"4563_CR10","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s12886-020-01379-z","volume":"20","author":"A Mu\u00f1oz-Gallego","year":"2020","unstructured":"Mu\u00f1oz-Gallego, A. et al. Interobserver reproducibility and interocular symmetry of the macular ganglion cell complex: Assessment in healthy children using optical coherence tomography. BMC Ophthalmol. 20, 197 (2020).","journal-title":"BMC Ophthalmol."},{"key":"4563_CR11","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/j.ophtha.2014.02.019","volume":"121","author":"YH Hwang","year":"2014","unstructured":"Hwang, Y. H., Jeong, Y. C., Kim, H. K. & Sohn, Y. H. Macular ganglion cell analysis for early detection of glaucoma. Ophthalmology 121, 1508\u20131515 (2014).","journal-title":"Ophthalmology"},{"key":"4563_CR12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1097\/WNO.0000000000001025","volume":"41","author":"J Jiang","year":"2021","unstructured":"Jiang, J. et al. Patterns of retinal ganglion cell damage in nonarteritic anterior ischemic optic neuropathy assessed by swept-source optical coherence tomography. J. Neuroophthalmol. 41, 37\u201347 (2021).","journal-title":"J. Neuroophthalmol."},{"key":"4563_CR13","doi-asserted-by":"publisher","first-page":"116823","DOI":"10.1016\/j.jns.2020.116823","volume":"414","author":"YJ Yoo","year":"2020","unstructured":"Yoo, Y. J. et al. Prognostic value of macular ganglion cell layer thickness for visual outcome in parasellar tumors. J. Neurol. Sci. 414, 116823 (2020).","journal-title":"J. Neurol. Sci."},{"key":"4563_CR14","doi-asserted-by":"publisher","first-page":"42480","DOI":"10.1038\/srep42480","volume":"7","author":"S Katagiri","year":"2017","unstructured":"Katagiri, S. et al. Retinal structure and function in eyes with optic nerve hypoplasia. Sci. Rep. 7, 42480 (2017).","journal-title":"Sci. Rep."},{"key":"4563_CR15","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1097\/IJG.0b013e31820719e1","volume":"21","author":"YH Hwang","year":"2012","unstructured":"Hwang, Y. H., Yoo, C. & Kim, Y. Y. Myopic optic disc tilt and the characteristics of peripapillary retinal nerve fiber layer thickness measured by spectral-domain optical coherence tomography. J. Glaucoma 21, 260\u2013351 (2012).","journal-title":"J. Glaucoma"},{"key":"4563_CR16","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.ophtha.2009.04.013","volume":"116","author":"CK Leung","year":"2009","unstructured":"Leung, C. K. et al. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: A variability and diagnostic performance study. Ophthalmology 116, 1257\u20131263 (2009).","journal-title":"Ophthalmology"},{"key":"4563_CR17","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1111\/cxo.12218","volume":"97","author":"YH Hwang","year":"2014","unstructured":"Hwang, Y. H., Song, M., Kim, Y. Y., Yeom, D. J. & Lee, J. H. Interocular symmetry of retinal nerve fibre layer thickness in healthy eyes: A spectral-domain optical coherence tomographic study. Clin. Exp. Optom. 97, 550\u2013554 (2014).","journal-title":"Clin. Exp. Optom."},{"key":"4563_CR18","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1097\/IJG.0b013e3181629a02","volume":"17","author":"DC Hood","year":"2008","unstructured":"Hood, D. C. et al. Blood vessel contributions to retinal nerve fiber layer thickness profiles measured with optical coherence tomography. J. Glaucoma 17, 519\u2013528 (2008).","journal-title":"J. Glaucoma"},{"key":"4563_CR19","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.ajo.2010.09.015","volume":"15","author":"JC Mwanza","year":"2011","unstructured":"Mwanza, J. C., Durbin, M. K. & Budenz, D. L. Interocular symmetry in peripapillary retinal nerve fiber layer thickness measured with the Cirrus HD-OCT in healthy eyes. Am. J. Ophthalmol. 15, 514\u201321.e1 (2011).","journal-title":"Am. J. Ophthalmol."},{"key":"4563_CR20","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1016\/j.ophtha.2013.07.021","volume":"120","author":"CKS Leung","year":"2013","unstructured":"Leung, C. K. S. et al. Impact of age-related change of retinal nerve fiber layer and macular thicknesses on evaluation of glaucoma progression. Ophthalmology 120, 2485\u20132492 (2013).","journal-title":"Ophthalmology"},{"key":"4563_CR21","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3341\/kjo.2012.26.3.163","volume":"26","author":"JY Lee","year":"2012","unstructured":"Lee, J. Y., Hwang, Y. H., Lee, S. M. & Kim, Y. Y. Age and retinal nerve fiber layer thickness measured by spectral domain optical coherence tomography. Korean J. Ophthalmol. 26, 163\u2013168 (2012).","journal-title":"Korean J. Ophthalmol."},{"key":"4563_CR22","doi-asserted-by":"publisher","first-page":"e213","DOI":"10.1097\/IJG.0000000000001834","volume":"30","author":"GD Miller","year":"2021","unstructured":"Miller, G. D., Abu-Qamar, O. & Salim, S. Evaluation of retinal nerve fiber layer, ganglion cell-inner plexiform layer, and optic nerve head in glaucoma suspects with varying myopia. J. Glaucoma. 30, e213\u2013e221 (2021).","journal-title":"J. Glaucoma."},{"key":"4563_CR23","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/s41433-020-0847-7","volume":"35","author":"B Lu","year":"2021","unstructured":"Lu, B. et al. Evaluation of the association of macular ganglion cell-inner plexiform layer thickness and myopia in Chinese young adults. Eye (London). 35, 393\u2013399 (2021).","journal-title":"Eye (London)."},{"key":"4563_CR24","doi-asserted-by":"publisher","first-page":"10605","DOI":"10.1038\/s41598-018-28870-4","volume":"8","author":"YP Lee","year":"2018","unstructured":"Lee, Y. P., Lu, Y. S. & Choi, D. G. Ganglion cell-inner plexiform layer thickness by swept-source optical coherence tomography in healthy Korean children: Normative data and biometric correlations. Sci. Rep. 8, 10605 (2018).","journal-title":"Sci. Rep."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-04563-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-04563-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-04563-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T15:51:27Z","timestamp":1669305087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-04563-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,13]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["4563"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-04563-3","relation":{"has-review":[{"id-type":"doi","id":"10.32388\/M9J0TP","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,13]]},"assertion":[{"value":"14 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"653"}}