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The present study aims to investigate the potential ameliorative effect of glycyrrhizic acid (GA) on diabetes-induced SMG damage. Experimental evaluation of GA treatment was conducted on a rat model of type I diabetes. Animals were assigned to three groups; control, diabetic and GA treated diabetic groups. After 8\u00a0weeks, the SMG was processed for assessment of oxidative stress markers, autophagy related proteins;\n                    <jats:italic>LC3<\/jats:italic>\n                    , Beclin-1 and P62, vascular regulator ET-1, aquaporins (AQPs 1.4 and 5),\n                    <jats:italic>SIRT1<\/jats:italic>\n                    protein expressions in addition to LC3 and AQP5 mRNA expressions. Also, parenchymal structures of the SMG were examined. GA alleviated the diabetes-induced SMG damage via restoring the SMG levels of oxidative stress markers and ET-1 almost near to the normal levels most probably via regulation of\n                    <jats:italic>SIRT1<\/jats:italic>\n                    , AQPs and accordingly LC-3, P62 and Beclin-1levels. GA could be a promising candidate for the treatment of diabetes-induced SMG damage via regulating oxidative stress, autophagy and angiogenesis.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-04594-w","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T06:02:40Z","timestamp":1642140160000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["RETRACTED ARTICLE: Glycyrrhizic acid ameliorates submandibular gland oxidative stress, autophagy and vascular dysfunction in rat model of type 1 diabetes"],"prefix":"10.1038","volume":"12","author":[{"given":"Saad Mohamed","family":"Asseri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal M.","family":"Elsherbiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El-Sherbiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman O.","family":"Sherif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alsamman M.","family":"Alsamman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia M.","family":"Maysarah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira M.","family":"Elsherbini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,14]]},"reference":[{"key":"4594_CR1","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1007\/s00125-017-4308-1","volume":"60","author":"SE Regnell","year":"2017","unstructured":"Regnell, S. 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