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This was a retrospective cohort study. Healthcare workers were routinely tested for SARS-CoV-2 infection using real-time polymerase chain reaction tests in nasopharyngeal swabs. Logistic regression was used to calculate the incidence rate ratios (IRRs) of the factors associated with COVID-19. A total of 4251 workers were followed up, and the prevalence of COVID-19 was 13.6%. In March 2021 the incidence of infection was 4.88 and 103.55 cases for 100,000 person-days in vaccinated and non-vaccinated workers, respectively, with an adjusted IRRs of 0.05 (95% CI 0.02\u20130.08). Our study evaluated the monthly incidence in health care workers in Trieste hospitals before and after vaccination, finding an estimated vaccine effectiveness of 95% in health care workers routinely tested.<\/jats:p>","DOI":"10.1038\/s41598-021-04665-y","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T11:03:01Z","timestamp":1644922981000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Incidence of COVID-19 infection in hospital workers from March 1, 2020 to May 31, 2021 routinely tested, before and after vaccination with BNT162B2"],"prefix":"10.1038","volume":"12","author":[{"given":"Francesca","family":"Larese Filon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Rui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Ronchese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"De Michieli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Negro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"issue":"3","key":"4665_CR1","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.jhin.2020.08.012","volume":"106","author":"L Piapan","year":"2020","unstructured":"Piapan, L. et al. COVID-19 outbreak in healthcare workers in hospitals in Trieste, North-east Italy. J. Hosp. Infect. 106(3), 626\u2013628. https:\/\/doi.org\/10.1016\/j.jhin.2020.08.012 (2020).","journal-title":"J. Hosp. Infect."},{"key":"4665_CR2","unstructured":"Istituto Superiore di Sanit\u00e0 (ISS). Speciale COVID-19 vaccini https:\/\/www.iss.it\/vaccini-covid-19 (accessed 2 Feb 2021)."},{"issue":"27","key":"4665_CR3","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","volume":"383","author":"FP Polack","year":"2020","unstructured":"Polack, F. P. et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N. Engl. J. Med. 383(27), 2603\u20132615. https:\/\/doi.org\/10.1056\/NEJMoa2034577 (2020).","journal-title":"N. Engl. J. Med."},{"key":"4665_CR4","unstructured":"US Food and Drug Agency. 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