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Galantamine is a licenced treatment for AD but supplies of the plant alkaloid that it is produced from, galanthamine, are limited. This three-year system study tested the potential to combine<jats:italic>Narcissus<\/jats:italic>-derived galanthamine production with grassland-based ruminant production. Replicate plots of permanent pasture were prepared with and without bulbs of<jats:italic>Narcissus pseudonarcissus<\/jats:italic>sown as lines into the sward. Two different fertiliser regimes were imposed. The above-ground green biomass of<jats:italic>N. pseudonarcissus<\/jats:italic>was harvested in early spring and the galanthamine yield determined. In the second harvest year a split-plot design was implemented with lines of<jats:italic>N. pseudonarcissus<\/jats:italic>cut annually and biennially. All plots were subsequently grazed by ewes and lambs and animal performance recorded. Incorporation of<jats:italic>N. pseudonarcissus<\/jats:italic>into grazed permanent pasture had no detrimental effects on the health or performance of the sheep which subsequently grazed the pasture. There was no consistency to the effects of fertiliser rates on galanthamine yields. There was no difference in overall galanthamine yield if<jats:italic>N. pseudonarcissus<\/jats:italic>was cut biennially (1.64 vs. 1.75\u00a0kg galanthamine\/ha for annual combined vs biennial cuts respectively; s.e.d\u2009=\u20090.117\u00a0kg galanthamine\/ha; ns). This study verified the feasibility of a dual cropping approach to producing plant-derived galanthamine.<\/jats:p>","DOI":"10.1038\/s41598-021-81042-9","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T11:11:08Z","timestamp":1610622668000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Integrating Narcissus-derived galanthamine production into traditional upland farming systems"],"prefix":"10.1038","volume":"11","author":[{"given":"M. D.","family":"Fraser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. E.","family":"Vallin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R. T.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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