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Distributions of the network parameters (corresponding to degree and eigenvector centrality) measured at each brain region for all 25 patients were significantly different from age- and sex-matched control data that were estimated by a healthy control dataset (n\u2009=\u2009582, 18\u201384\u00a0years old). The number of abnormal regions whose parameters exceeded the mean\u2009+\u20092 SD of age- and sex-matched data for each patient were associated with various clinical parameters such as the duration of illness and seizure severity. Furthermore, abnormal regions for each patient tended to have functional connections with each other (mean\u2009\u00b1\u2009SD\u2009=\u200958.6\u2009\u00b1\u200920.2%), the magnitude of which was negatively related to the quality of life. The abnormal regions distributed within the default mode network with significantly higher probability (p\u2009&lt;\u20090.05) in 7 of 25 patients. We consider that the detection of abnormal regions by functional connectivity analysis using a large number of control datasets is useful for the numerical assessment of each patient\u2019s clinical conditions, although further study is necessary to elucidate etiology-specific abnormalities.<\/jats:p>","DOI":"10.1038\/s41598-021-81207-6","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T11:02:30Z","timestamp":1610708550000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy"],"prefix":"10.1038","volume":"11","author":[{"given":"Yasuo","family":"Nakai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Nishibayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Donishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Terada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Kaneoke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"81207_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/S1474-4422(02)00003-0","volume":"1","author":"B Litt","year":"2002","unstructured":"Litt, B. & Echauz, J. 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