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The study aimed to investigate the relationship between the intestinal microbiota and the key immune cells. Fecal microbiota transplantation (FMT) was used to determine whether ALF can balance Th17\/Treg cytokines. The relationship between gut microbiota and clinical indicators was analyzed. BALB\/c mice were treated with <jats:sc>d<\/jats:sc>-galactosamine (<jats:sc>d<\/jats:sc>-GalN) to induce a murine ALF model. FMT to <jats:sc>d<\/jats:sc>-GalN mice was conducted to test for liver function indicators. Results showed that the proportions of <jats:italic>Lachnospiraceae<\/jats:italic>, <jats:italic>Prevotella<\/jats:italic>, <jats:italic>S24-7<\/jats:italic>, <jats:italic>Odoribacter<\/jats:italic> and <jats:italic>Rikenellaceae<\/jats:italic> in <jats:sc>d<\/jats:sc>-GalN mice with intestinal microbiota disorder were restored after FMT. Further, CIA analysis showed that bacteria had a covariant relationship with clinical indicators. Microbiota could account for changes in 49.9% of the overall clinical indicators. Adonis analysis showed that <jats:italic>Ruminococcus<\/jats:italic>, and <jats:italic>Enterococcus<\/jats:italic> have a greater impact on clinical indicators. FMT down-regulated the expression of IL-17A, TNF-\u03b1, and TGF-\u03b2, while up-regulated IL-10 and IL-22. Transplantation of feces from <jats:italic>Saccharomyces boulardii<\/jats:italic> donor mice improved GalN-induced liver damage. These findings indicate that FMT attenuates <jats:sc>d<\/jats:sc>-GalN-induced liver damage in mice, and a clinical trial is required to validate the relevance of our findings in humans, and to test whether this therapeutic approach is effective for patients with ALF.<\/jats:p>","DOI":"10.1038\/s41598-021-81263-y","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T11:02:30Z","timestamp":1610708550000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Fecal transplantation alleviates acute liver injury in mice through regulating Treg\/Th17 cytokines balance"],"prefix":"10.1038","volume":"11","author":[{"given":"Yongmei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiju","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueke","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingliang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"81263_CR1","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.cld.2017.06.002","volume":"21","author":"C Bunchorntavakul","year":"2017","unstructured":"Bunchorntavakul, C. & Reddy, K. 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