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This study aimed to evaluate whether the triglyceride (TyG) index was associated with peak GH in children with short stature. This study included 1095 children with short stature divided into two groups based on peak GH level in GH provocation tests [GH deficiency (GHD) group\u2009=\u2009733 children; non-GHD group\u2009=\u2009362 children]. We found that the TyG index was significantly higher in the GHD group than in the non-GHD group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). A nonlinear relationship was detected between the TyG index and peak GH, whose point was 7.8. A significant negative association between the TyG index and peak GH was observed when the TyG index was greater than 7.8 (\u03b2 \u2212\u20092.61, 95% CI \u2212\u20093.98, \u2212\u20091.24;<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), whereas, the relationship between the TyG index and peak GH was not significant when the TyG index was lower than 7.8 (\u03b2 0.25, 95% CI \u2212\u20091.68, 2.17;<jats:italic>P<\/jats:italic>\u2009=\u20090.799). There is a nonlinear relationship between the TyG index and peak GH, and a higher TyG index is associated with decreased peak GH in children with short stature.<\/jats:p>","DOI":"10.1038\/s41598-021-81564-2","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T11:03:39Z","timestamp":1611227019000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between triglyceride glucose index and peak growth hormone in children with short stature"],"prefix":"10.1038","volume":"11","author":[{"given":"Qianqian","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuntian","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Ban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"81564_CR1","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1093\/pch\/pxy079","volume":"24","author":"D Yue","year":"2019","unstructured":"Yue, D., Miller, M. 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