{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:49:23Z","timestamp":1784159363094,"version":"3.55.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The failure rate of TAA is still higher than that of other joint replacement procedures. This study aimed to calculate the early failure rate and identify associated patient factors. Data from the Korean Health Insurance Review and Assessment Service database from 2009 to 2017 were collected. We evaluated patients who had TAA as a primary surgical procedure. Early failure was defined as conversion to revision TAA or arthrodesis after primary TAA within five years. Patients with early failure after primary TAA were designated as the \u201cFailure group\u201d. Patients without early failure and who were followed up unremarkably for at least five years after primary TAA were designated as the \u201cNo failure group\u201d. Overall, 2157 TAA participants were included. During the study period, 197 patients developed failure within five years postoperatively, for an overall failure rate of 9.1%. Significant risk factors for early failure were history of chronic pulmonary disease, diabetes, peripheral vascular disease, hyperlipidemia, dementia, and alcohol abuse. A significant increase of odds ratio was found in patients with a history of dementia, chronic pulmonary disease, and diabetes. Surgical indications and preoperative patient counseling should consider these factors.<\/jats:p>","DOI":"10.1038\/s41598-021-81576-y","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T11:03:39Z","timestamp":1611227019000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Analysis of early failure rate and its risk factor with 2157 total ankle replacements"],"prefix":"10.1038","volume":"11","author":[{"given":"Jung Woo","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Young","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Young","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"81576_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.fcl.2017.01.013","volume":"22","author":"J Morash","year":"2017","unstructured":"Morash, J., Walton, D. M. & Glazebrook, M. Ankle arthrodesis versus total ankle arthroplasty. Foot Ankle Clin. 22, 251\u2013266. https:\/\/doi.org\/10.1016\/j.fcl.2017.01.013 (2017).","journal-title":"Foot Ankle Clin."},{"key":"81576_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2019.07.006","author":"JR Onggo","year":"2019","unstructured":"Onggo, J. R. et al. Outcome after total ankle arthroplasty with a minimum of five years follow-up: a systematic review and meta-analysis. Foot Ankle Surg. https:\/\/doi.org\/10.1016\/j.fas.2019.07.006 (2019).","journal-title":"Foot Ankle Surg."},{"key":"81576_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4055\/cios.2010.2.1.1","volume":"2","author":"CL Saltzman","year":"2010","unstructured":"Saltzman, C. L., Kadoko, R. G. & Suh, J. S. Treatment of isolated ankle osteoarthritis with arthrodesis or the total ankle replacement: a comparison of early outcomes. Clin. Orthop. Surg. 2, 1\u20137. https:\/\/doi.org\/10.4055\/cios.2010.2.1.1 (2010).","journal-title":"Clin. Orthop. Surg."},{"key":"81576_CR4","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1007\/s00264-013-1981-7","volume":"37","author":"G Labek","year":"2013","unstructured":"Labek, G., Todorov, S., Iovanescu, L., Stoica, C. I. & Bohler, N. Outcome after total ankle arthroplasty-results and findings from worldwide arthroplasty registers. Int. Orthop. 37, 1677\u20131682. https:\/\/doi.org\/10.1007\/s00264-013-1981-7 (2013).","journal-title":"Int. Orthop."},{"key":"81576_CR5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00264-016-3303-3","volume":"41","author":"HJ Kim","year":"2017","unstructured":"Kim, H. J. et al. Total ankle arthroplasty versus ankle arthrodesis for the treatment of end-stage ankle arthritis: a meta-analysis of comparative studies. Int. Orthop. 41, 101\u2013109. https:\/\/doi.org\/10.1007\/s00264-016-3303-3 (2017).","journal-title":"Int. Orthop."},{"key":"81576_CR6","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1007\/s11999-014-3836-y","volume":"472","author":"S Bekkers","year":"2014","unstructured":"Bekkers, S., Bot, A. G., Makarawung, D., Neuhaus, V. & Ring, D. The National Hospital discharge survey and nationwide inpatient sample: the databases used affect results in THA research. Clin. Orthop. Relat. Res. 472, 3441\u20133449. https:\/\/doi.org\/10.1007\/s11999-014-3836-y (2014).","journal-title":"Clin. Orthop. Relat. Res."},{"key":"81576_CR7","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1177\/1938640016640891","volume":"9","author":"J LaMothe","year":"2016","unstructured":"LaMothe, J., Seaworth, C. M., Do, H. T., Kunas, G. C. & Ellis, S. J. Analysis of total ankle arthroplasty survival in the United States using multiple state databases. Foot Ankle Spec. 9, 336\u2013341. https:\/\/doi.org\/10.1177\/1938640016640891 (2016).","journal-title":"Foot Ankle Spec."},{"key":"81576_CR8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.fas.2010.02.007","volume":"17","author":"A Henricson","year":"2011","unstructured":"Henricson, A., Carlsson, A. & Rydholm, U. What is a revision of total ankle replacement?. Foot Ankle Surg. 17, 99\u2013102. https:\/\/doi.org\/10.1016\/j.fas.2010.02.007 (2011).","journal-title":"Foot Ankle Surg."},{"key":"81576_CR9","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1177\/1071100715609719","volume":"37","author":"J Mercer","year":"2016","unstructured":"Mercer, J., Penner, M., Wing, K. & Younger, A. S. Inconsistency in the reporting of adverse events in total ankle arthroplasty: a systematic review of the literature. Foot Ankle Int. 37, 127\u2013136. https:\/\/doi.org\/10.1177\/1071100715609719 (2016).","journal-title":"Foot Ankle Int."},{"key":"81576_CR10","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","volume":"43","author":"H Quan","year":"2005","unstructured":"Quan, H. et al. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med. Care 43, 1130\u20131139. https:\/\/doi.org\/10.1097\/01.mlr.0000182534.19832.83 (2005).","journal-title":"Med. Care"},{"key":"81576_CR11","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.2106\/JBJS.15.01060","volume":"98","author":"E Jeschke","year":"2016","unstructured":"Jeschke, E. et al. Five-year survival of 20,946 unicondylar knee replacements and patient risk factors for failure: an analysis of German insurance data. J. Bone Jt. Surg. Am. 98, 1691\u20131698. https:\/\/doi.org\/10.2106\/JBJS.15.01060 (2016).","journal-title":"J. Bone Jt. Surg. Am."},{"key":"81576_CR12","doi-asserted-by":"publisher","first-page":"740","DOI":"10.3113\/fai.2011.0740","volume":"32","author":"G Labek","year":"2011","unstructured":"Labek, G., Klaus, H., Schlichtherle, R., Williams, A. & Agreiter, M. Revision rates after total ankle arthroplasty in sample-based clinical studies and national registries. Foot Ankle Int. 32, 740\u2013745. https:\/\/doi.org\/10.3113\/fai.2011.0740 (2011).","journal-title":"Foot Ankle Int."},{"key":"81576_CR13","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.ocl.2019.06.004","volume":"50","author":"L Jeyaseelan","year":"2019","unstructured":"Jeyaseelan, L. et al. Outcomes following total ankle arthroplasty: a review of the registry data and current literature. Orthop. Clin. North Am. 50, 539\u2013548. https:\/\/doi.org\/10.1016\/j.ocl.2019.06.004 (2019).","journal-title":"Orthop. Clin. North Am."},{"key":"81576_CR14","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3928\/01477447-20160427-12","volume":"39","author":"CM Seaworth","year":"2016","unstructured":"Seaworth, C. M. et al. Epidemiology of total ankle arthroplasty: trends in New York state. Orthopedics 39, 170\u2013176. https:\/\/doi.org\/10.3928\/01477447-20160427-12 (2016).","journal-title":"Orthopedics"},{"key":"81576_CR15","doi-asserted-by":"publisher","first-page":"e021784","DOI":"10.1136\/bmjopen-2018-021784","volume":"8","author":"B Podmore","year":"2018","unstructured":"Podmore, B., Hutchings, A., van der Meulen, J., Aggarwal, A. & Konan, S. Impact of comorbid conditions on outcomes of hip and knee replacement surgery: a systematic review and meta-analysis. BMJ Open 8, e021784. https:\/\/doi.org\/10.1136\/bmjopen-2018-021784 (2018).","journal-title":"BMJ Open"},{"key":"81576_CR16","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1002\/acr.22240","volume":"66","author":"CJ Dy","year":"2014","unstructured":"Dy, C. J. et al. Risk factors for early revision after total hip arthroplasty. Arthritis. Care Res. (Hoboken) 66, 907\u2013915. https:\/\/doi.org\/10.1002\/acr.22240 (2014).","journal-title":"Arthritis. Care Res. (Hoboken)"},{"key":"81576_CR17","doi-asserted-by":"publisher","first-page":"e0214855","DOI":"10.1371\/journal.pone.0214855","volume":"14","author":"A Bottle","year":"2019","unstructured":"Bottle, A., Parikh, S., Aylin, P. & Loeffler, M. Risk factors for early revision after total hip and knee arthroplasty: national observational study from a surgeon and population perspective. PLoS ONE 14, e0214855. https:\/\/doi.org\/10.1371\/journal.pone.0214855 (2019).","journal-title":"PLoS ONE"},{"key":"81576_CR18","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1503\/cjs.007117","volume":"61","author":"C Rhee","year":"2018","unstructured":"Rhee, C., Lethbridge, L., Richardson, G. & Dunbar, M. Risk factors for infection, revision, death, blood transfusion and longer hospital stay 3 months and 1 year after primary total hip or knee arthroplasty. Can. J. Surg. 61, 165\u2013176. https:\/\/doi.org\/10.1503\/cjs.007117 (2018).","journal-title":"Can. J. Surg."},{"key":"81576_CR19","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1016\/j.arth.2017.12.034","volume":"33","author":"EB Gausden","year":"2018","unstructured":"Gausden, E. B., Parhar, H. S., Popper, J. E., Sculco, P. K. & Rush, B. N. M. Risk Factors for early dislocation following primary elective total hip arthroplasty. J. Arthroplasty 33, 1567-1571.e1562. https:\/\/doi.org\/10.1016\/j.arth.2017.12.034 (2018).","journal-title":"J. Arthroplasty"},{"key":"81576_CR20","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.2106\/JBJS.17.01149","volume":"100","author":"D Cunningham","year":"2018","unstructured":"Cunningham, D. et al. Patient risk factors do not impact 90-day readmission and emergency department visitation after total ankle arthroplasty: implications for the comprehensive care for joint replacement (CJR) bundled payment plan. J. Bone Jt. Surg. Am. 100, 1289\u20131297. https:\/\/doi.org\/10.2106\/JBJS.17.01149 (2018).","journal-title":"J. Bone Jt. Surg. Am."},{"key":"81576_CR21","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s10067-019-04826-5","volume":"39","author":"JA Singh","year":"2020","unstructured":"Singh, J. A. & Cleveland, J. D. Age, race, comorbidity, and insurance payer type are associated with outcomes after total ankle arthroplasty. Clin. Rheumatol. 39, 881\u2013890. https:\/\/doi.org\/10.1007\/s10067-019-04826-5 (2020).","journal-title":"Clin. Rheumatol."},{"key":"81576_CR22","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.3928\/01477447-20151228-05","volume":"39","author":"H Zhou","year":"2016","unstructured":"Zhou, H., Yakavonis, M., Shaw, J. J., Patel, A. & Li, X. In-patient trends and complications after total ankle arthroplasty in the United States. Orthopedics 39, e74-79. https:\/\/doi.org\/10.3928\/01477447-20151228-05 (2016).","journal-title":"Orthopedics"},{"key":"81576_CR23","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1177\/1938640017709912","volume":"11","author":"KA Heida","year":"2018","unstructured":"Heida, K. A. et al. Short-term perioperative complications and mortality after total ankle arthroplasty in the United States. Foot Ankle Spec. 11, 123\u2013132. https:\/\/doi.org\/10.1177\/1938640017709912 (2018).","journal-title":"Foot Ankle Spec."},{"key":"81576_CR24","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1177\/1071100715576569","volume":"36","author":"BC Werner","year":"2015","unstructured":"Werner, B. C. et al. Obesity is associated with increased complications after operative management of end-stage ankle arthritis. Foot Ankle Int. 36, 863\u2013870. https:\/\/doi.org\/10.1177\/1071100715576569 (2015).","journal-title":"Foot Ankle Int."},{"key":"81576_CR25","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s11999-011-2043-3","volume":"470","author":"KJ Bozic","year":"2012","unstructured":"Bozic, K. J., Lau, E., Kurtz, S., Ong, K. & Berry, D. J. Patient-related risk factors for postoperative mortality and periprosthetic joint infection in medicare patients undergoing TKA. Clin. Orthop. Relat. Res. 470, 130\u2013137. https:\/\/doi.org\/10.1007\/s11999-011-2043-3 (2012).","journal-title":"Clin. Orthop. Relat. Res."},{"key":"81576_CR26","doi-asserted-by":"publisher","first-page":"794","DOI":"10.2106\/jbjs.K.00072","volume":"94","author":"KJ Bozic","year":"2012","unstructured":"Bozic, K. J. et al. Patient-related risk factors for periprosthetic joint infection and postoperative mortality following total hip arthroplasty in Medicare patients. J. Bone Jt. Surg. Am. 94, 794\u2013800. https:\/\/doi.org\/10.2106\/jbjs.K.00072 (2012).","journal-title":"J. Bone Jt. Surg. Am."},{"key":"81576_CR27","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1302\/0301-620x.97b5.34382","volume":"97-b","author":"E Jamsen","year":"2015","unstructured":"Jamsen, E., Peltola, M., Puolakka, T., Eskelinen, A. & Lehto, M. U. Surgical outcomes of hip and knee arthroplasties for primary osteoarthritis in patients with Alzheimer\u2019s disease: a nationwide registry-based case-controlled study. Bone Jt. J. 97-b, 654\u2013661. https:\/\/doi.org\/10.1302\/0301-620x.97b5.34382 (2015).","journal-title":"Bone Jt. J."},{"key":"81576_CR28","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/s1473-3099(18)30345-1","volume":"18","author":"E Lenguerrand","year":"2018","unstructured":"Lenguerrand, E. et al. Risk factors associated with revision for prosthetic joint infection after hip replacement: a prospective observational cohort study. Lancet Infect. Dis. 18, 1004\u20131014. https:\/\/doi.org\/10.1016\/s1473-3099(18)30345-1 (2018).","journal-title":"Lancet Infect. Dis."},{"key":"81576_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.01.070","author":"NM Hernandez","year":"2020","unstructured":"Hernandez, N. M., Cunningham, D. J., Jiranek, W. A., Bolognesi, M. P. & Seyler, T. M. Total hip arthroplasty in patients with dementia. J. Arthroplasty https:\/\/doi.org\/10.1016\/j.arth.2020.01.070 (2020).","journal-title":"J. Arthroplasty"},{"key":"81576_CR30","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1177\/2151458516669203","volume":"7","author":"J Puustinen","year":"2016","unstructured":"Puustinen, J. et al. The use of MoCA and other cognitive tests in evaluation of cognitive impairment in elderly patients undergoing arthroplasty. Geriatr. Orthop. Surg. Rehabil. 7, 183\u2013187. https:\/\/doi.org\/10.1177\/2151458516669203 (2016).","journal-title":"Geriatr. Orthop. Surg. Rehabil."},{"key":"81576_CR31","doi-asserted-by":"publisher","first-page":"e5521","DOI":"10.1371\/journal.pone.0005521","volume":"4","author":"LM Allan","year":"2009","unstructured":"Allan, L. M., Ballard, C. G., Rowan, E. N. & Kenny, R. A. Incidence and prediction of falls in dementia: a prospective study in older people. PLoS ONE 4, e5521. https:\/\/doi.org\/10.1371\/journal.pone.0005521 (2009).","journal-title":"PLoS ONE"},{"key":"81576_CR32","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3988\/jcn.2019.15.2.243","volume":"15","author":"JH Jeon","year":"2019","unstructured":"Jeon, J. H. et al. Dementia is associated with an increased risk of hip fractures: a nationwide analysis in Korea. J. Clin. Neurol. 15, 243\u2013249. https:\/\/doi.org\/10.3988\/jcn.2019.15.2.243 (2019).","journal-title":"J. Clin. Neurol."},{"key":"81576_CR33","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.2147\/copd.S161577","volume":"13","author":"A Klasan","year":"2018","unstructured":"Klasan, A. et al. COPD as a risk factor of the complications in lower limb arthroplasty: a patient-matched study. Int. J. Chron. Obstruct. Pulmon. Dis. 13, 2495\u20132499. https:\/\/doi.org\/10.2147\/copd.S161577 (2018).","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"81576_CR34","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1016\/j.arth.2018.03.011","volume":"33","author":"GA Yakubek","year":"2018","unstructured":"Yakubek, G. A. et al. Chronic obstructive pulmonary disease is associated with short-term complications following total knee arthroplasty. J. Arthroplasty 33, 2623\u20132626. https:\/\/doi.org\/10.1016\/j.arth.2018.03.011 (2018).","journal-title":"J. Arthroplasty"},{"key":"81576_CR35","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1016\/j.arth.2017.12.043","volume":"33","author":"GA Yakubek","year":"2018","unstructured":"Yakubek, G. A. et al. Chronic obstructive pulmonary disease is associated with short-term complications following total hip arthroplasty. J. Arthroplasty 33, 1926\u20131929. https:\/\/doi.org\/10.1016\/j.arth.2017.12.043 (2018).","journal-title":"J. Arthroplasty"},{"key":"81576_CR36","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s11999-013-3045-0","volume":"472","author":"KJ Bozic","year":"2014","unstructured":"Bozic, K. J. et al. Risk factors for early revision after primary TKA in Medicare patients. Clin. Orthop. Relat. Res. 472, 232\u2013237. https:\/\/doi.org\/10.1007\/s11999-013-3045-0 (2014).","journal-title":"Clin. Orthop. Relat. Res."},{"key":"81576_CR37","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1007\/s11999-013-3416-6","volume":"472","author":"CJ Dy","year":"2014","unstructured":"Dy, C. J. et al. Risk factors for revision within 10 years of total knee arthroplasty. Clin. Orthop. Relat. Res. 472, 1198\u20131207. https:\/\/doi.org\/10.1007\/s11999-013-3416-6 (2014).","journal-title":"Clin. Orthop. Relat. Res."},{"key":"81576_CR38","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1177\/1071100715585575","volume":"36","author":"CE Gross","year":"2015","unstructured":"Gross, C. E. et al. Impact of diabetes on outcome of total ankle replacement. Foot Ankle Int. 36, 1144\u20131149. https:\/\/doi.org\/10.1177\/1071100715585575 (2015).","journal-title":"Foot Ankle Int."},{"key":"81576_CR39","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1177\/1071100714568869","volume":"36","author":"D Patton","year":"2015","unstructured":"Patton, D., Kiewiet, N. & Brage, M. Infected total ankle arthroplasty: risk factors and treatment options. Foot Ankle Int. 36, 626\u2013634. https:\/\/doi.org\/10.1177\/1071100714568869 (2015).","journal-title":"Foot Ankle Int."},{"key":"81576_CR40","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1177\/1071100719849084","volume":"40","author":"MI Escudero","year":"2019","unstructured":"Escudero, M. I. et al. Total ankle arthroplasty survival and risk factors for failure. Foot Ankle Int. 40, 997\u20131006. https:\/\/doi.org\/10.1177\/1071100719849084 (2019).","journal-title":"Foot Ankle Int."},{"key":"81576_CR41","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1302\/0301-620x.96b12.34364","volume":"96","author":"WJ Choi","year":"2014","unstructured":"Choi, W. J., Lee, J. S., Lee, M., Park, J. H. & Lee, J. W. The impact of diabetes on the short- to mid-term outcome of total ankle replacement. Bone Jt. J. 96, 1674\u20131680. https:\/\/doi.org\/10.1302\/0301-620x.96b12.34364 (2014).","journal-title":"Bone Jt. J."},{"key":"81576_CR42","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1177\/1071100719840816","volume":"40","author":"GW Lee","year":"2019","unstructured":"Lee, G. W., Seon, J. K., Kim, N. S. & Lee, K. B. Comparison of intermediate-term outcomes of total ankle arthroplasty in patients younger and older than 55 years. Foot Ankle Int. 40, 762\u2013768. https:\/\/doi.org\/10.1177\/1071100719840816 (2019).","journal-title":"Foot Ankle Int."},{"key":"81576_CR43","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.2106\/JBJS.L.01234","volume":"95","author":"A Barg","year":"2013","unstructured":"Barg, A., Zwicky, L., Knupp, M., Henninger, H. B. & Hintermann, B. HINTEGRA total ankle replacement: survivorship analysis in 684 patients. J. Bone Jt. Surg. Am. 95, 1175\u20131183. https:\/\/doi.org\/10.2106\/JBJS.L.01234 (2013).","journal-title":"J. Bone Jt. Surg. Am."},{"key":"81576_CR44","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1177\/1071100715579717","volume":"36","author":"CA Demetracopoulos","year":"2015","unstructured":"Demetracopoulos, C. A. et al. Effect of age on outcomes in total ankle arthroplasty. Foot Ankle Int. 36, 871\u2013880. https:\/\/doi.org\/10.1177\/1071100715579717 (2015).","journal-title":"Foot Ankle Int."},{"key":"81576_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1071100715604392","volume":"37","author":"ON Schipper","year":"2016","unstructured":"Schipper, O. N., Denduluri, S. K., Zhou, Y. & Haddad, S. L. Effect of obesity on total ankle arthroplasty outcomes. Foot Ankle Int. 37, 1\u20137. https:\/\/doi.org\/10.1177\/1071100715604392 (2016).","journal-title":"Foot Ankle Int."},{"key":"81576_CR46","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1053\/j.jfas.2019.07.001","volume":"59","author":"TY Kim","year":"2020","unstructured":"Kim, T. Y., Lee, H. W. & Jeong, B. O. Influence of depressive symptoms on the clinical outcomes of total ankle arthroplasty. J. Foot Ankle Surg. 59, 59\u201363. https:\/\/doi.org\/10.1053\/j.jfas.2019.07.001 (2020).","journal-title":"J. Foot Ankle Surg."},{"key":"81576_CR47","doi-asserted-by":"publisher","first-page":"342","DOI":"10.2106\/JBJS.16.00097","volume":"99","author":"T Lefrancois","year":"2017","unstructured":"Lefrancois, T. et al. A prospective study of four total ankle arthroplasty implants by non-designer investigators. J. Bone Jt. Surg. Am. 99, 342\u2013348. https:\/\/doi.org\/10.2106\/JBJS.16.00097 (2017).","journal-title":"J. Bone Jt. Surg. Am."},{"key":"81576_CR48","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1177\/1071100718806474","volume":"40","author":"EA Cody","year":"2019","unstructured":"Cody, E. A. et al. Risk factors for failure of total ankle arthroplasty with a minimum five years of follow-up. Foot Ankle Int. 40, 249\u2013258. https:\/\/doi.org\/10.1177\/1071100718806474 (2019).","journal-title":"Foot Ankle Int."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-81576-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-81576-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-81576-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T02:29:53Z","timestamp":1670034593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-81576-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,21]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["81576"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-81576-y","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,21]]},"assertion":[{"value":"6 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1901"}}