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Seventy-four women undergoing robotic gynecologic surgery were randomly assigned to two equal groups. Moderate NMB group was maintained with a train of four count of 1\u20132 and PP at 12\u00a0mmHg. Deep NMB group was maintained with a post-tetanic count of 1\u20132 and PP at 8\u00a0mmHg. Inflammatory cytokines were measured at baseline, at the end of PP, and 24\u00a0h after surgery. Interleukin-6 increased significantly from baseline at the end of PP and 24\u00a0h after the surgery in moderate NMB group but not in deep NMB group (<jats:italic>P<\/jats:italic><jats:sub><jats:italic>group*time<\/jats:italic><\/jats:sub>\u2009=\u20090.036). The peak inspiratory, driving, and mean airway pressures were significantly higher in moderate NMB group than in deep NMB group at 15\u00a0min and 60\u00a0min after PP (<jats:italic>P<\/jats:italic><jats:sub><jats:italic>group*time<\/jats:italic><\/jats:sub>\u2009=\u20090.002, 0.003, and 0.048, respectively). In conclusion, deep NMB with low-pressure PP significantly suppressed the increase in interleukin-6 developed after PP, by significantly improving the respiratory mechanics compared to moderate NMB with high-pressure PP during robotic surgery.<\/jats:p>","DOI":"10.1038\/s41598-021-81582-0","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T11:03:39Z","timestamp":1611227019000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of deep neuromuscular block with low-pressure pneumoperitoneum on respiratory mechanics and biotrauma in a steep Trendelenburg position"],"prefix":"10.1038","volume":"11","author":[{"given":"Ji Eun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Kee","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunji","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongchul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Yeop","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jeong","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"81582_CR1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00404-020-05606-2","volume":"302","author":"Q Xu","year":"2020","unstructured":"Xu, Q. et al. 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