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Perceived stress may influence the direction of these effects. Using a longitudinal twin design, we investigated how perceived stress influenced lockdown induced changes in wellbeing of parents and children. A total of 106 parents and 151 children (10\u201313-year-olds) filled in questionnaires during lockdown and data were combined with data of previous years. We report a significant increase in parental negative feelings (anxiety, depression, hostility and interpersonal sensitivity). Longitudinal child measures showed a gradual decrease in internalizing and externalizing behavior, which seemed decelerated by the COVID-19 lockdown. Changes in parental negative feelings and children\u2019s externalizing behavior were mediated by perceived stress: higher scores prior to the lockdown were related to more stress during the lockdown, which in turn was associated with an increase in parental negative feelings and children\u2019s\u2019 externalizing behavior. Perceived stress in parents and children was associated with negative coping strategies. Additionally, children\u2019s stress levels were influenced by prior and current parental overreactivity. These results suggest that children in families with negative coping strategies and (a history of) parental overreactivity might be at risk for negative consequences of the lockdown.<\/jats:p>","DOI":"10.1038\/s41598-021-81720-8","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T11:10:36Z","timestamp":1612350636000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":224,"title":["Perceived stress as mediator for longitudinal effects of the COVID-19 lockdown on wellbeing of parents and children"],"prefix":"10.1038","volume":"11","author":[{"given":"Michelle","family":"Achterberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Dobbelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga D.","family":"Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline A.","family":"Crone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"81720_CR1","doi-asserted-by":"publisher","first-page":"100805","DOI":"10.1016\/j.dcn.2020.100805","volume":"45","author":"EA Crone","year":"2020","unstructured":"Crone, E. 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