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We included 18 eyes of 18 pediatric or juvenile patients with CP and 20 healthy controls. Each thickness of the macular retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer, outer plexiform layer, outer nuclear layer, and photoreceptor layer was compared between the CP patients and healthy controls. There was significant thinning in the macular RNFL (estimates [\u03bcm], superior, \u2212\u00a010.68; inferior, \u2212\u00a07.24; nasal, \u2212\u00a014.22), all quadrants of GCL (superior, \u2212\u00a016.53; inferior, \u2212\u00a014.37; nasal, \u2212\u00a024.34; temporal, \u2212\u00a09.91) and IPL (superior, \u2212\u00a011.45; inferior, \u2212\u00a09.76; nasal, \u2212\u00a015.25; temporal, \u2212\u00a04.97) in pediatric and juvenile CP patients postoperatively compared to healthy control eyes after adjusting for age and refractive errors. Thickness reduction in the average and nasal quadrant of RNFL, GCL, and IPL was associated with peripapillary RNFL thickness, and reduced nasal quadrant GCL and IPL thicknesses were associated with postoperative visual field defects. In pediatric and juvenile patients with CP, decreased inner retinal layer thickness following chiasmal compression was observed. The changes in retinal structures were closely related to peripapillary RNFL thinning and functional outcomes.<\/jats:p>","DOI":"10.1038\/s41598-021-82107-5","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T12:57:54Z","timestamp":1612270674000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma"],"prefix":"10.1038","volume":"11","author":[{"given":"Ga-In","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Ah","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei Yeul","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doo-Sik","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Duk","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"82107_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s11102-012-0401-0","volume":"16","author":"HL Muller","year":"2013","unstructured":"Muller, H. 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