{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:39:18Z","timestamp":1787236758905,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000672","name":"Pathological Society of Great Britain and Ireland","doi-asserted-by":"publisher","award":["JSPS CLG 2019 02"],"award-info":[{"award-number":["JSPS CLG 2019 02"]}],"id":[{"id":"10.13039\/501100000672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001308","name":"Jean Shanks Foundation","doi-asserted-by":"publisher","award":["JSPS CLG 2019 02"],"award-info":[{"award-number":["JSPS CLG 2019 02"]}],"id":[{"id":"10.13039\/501100001308","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    BK virus associated nephropathy (BKN) is an important cause of kidney allograft failure. In a cohort of paediatric kidney transplant recipients, we aimed to understand the incidence and clinical outcome associated with BKN, as well as identify risk factors for BKN and BK viraemia development. We retrospectively analysed all patients who received a kidney transplant and received follow up care in our centre between 2009\u20132019. Among 106 patients included in the study (mean follow up 4.5\u00a0years), 32\/106 (30.2%) patients experienced BK viraemia. The incidence of BKN was 7\/106 (6.6%). The median time of BK viraemia development post-transplant was 279.5\u00a0days compared to 90.0\u00a0days for BKN. Development of BKN was associated with younger age at transplantation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.013). Development of BK viraemia was associated with negative recipient serology for cytomegalovirus (CMV) at time of transplantation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012) and a higher net level of immunosuppression (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.039). There was no difference in graft function at latest follow up between those who experienced BKN and those without BKN. This study demonstrates that BK virus infection is associated with younger age at transplantation, CMV negative recipient serostatus and higher levels of immunosuppression. Judicious monitoring of BK viraemia in paediatric transplant recipients, coupled with timely clinical intervention can result in similar long-term outcomes for BKN patients compared to controls.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-82160-0","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T06:04:39Z","timestamp":1611813879000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["BK virus infection and outcome following kidney transplantation in childhood"],"prefix":"10.1038","volume":"11","author":[{"given":"James","family":"McCaffrey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijesh J.","family":"Bhute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Shenoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"82160_CR1","first-page":"1627","volume":"156","author":"R Johne","year":"2011","unstructured":"Johne, R. et al. 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Pediatr. Nephrol. 22, 1243\u20131250 (2007).","journal-title":"Pediatr. Nephrol."},{"key":"82160_CR7","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1097\/TP.0b013e31816a32fc","volume":"85","author":"LH White","year":"2008","unstructured":"White, L. H. et al. BK virus nephropathy in renal transplant patients in London. Transplantation 85, 1008\u20131015 (2008).","journal-title":"Transplantation"},{"key":"82160_CR8","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1111\/j.1399-3046.2004.00154.x","volume":"8","author":"L Haysom","year":"2004","unstructured":"Haysom, L. et al. BK viral infection in an Australian pediatric renal transplant population. Pediatr. Transplant. 8, 480\u2013484 (2004).","journal-title":"Pediatr. Transplant."},{"key":"82160_CR9","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1056\/NEJM200005043421802","volume":"342","author":"V Nickeleit","year":"2000","unstructured":"Nickeleit, V. et al. Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy. N. Engl. J. Med. 342, 1309\u20131315 (2000).","journal-title":"N. Engl. J. Med."},{"key":"82160_CR10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/00007890-199901150-00018","volume":"67","author":"PS Randhawa","year":"1999","unstructured":"Randhawa, P. S. et al. Human polyoma virus-associated interstitial nephritis in the allograft kidney. Transplantation 67, 103\u2013109 (1999).","journal-title":"Transplantation"},{"key":"82160_CR11","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1093\/ndt\/gfn675","volume":"24","author":"SW Wu","year":"2009","unstructured":"Wu, S. W., Chang, H. R. & da Lian, J. The effect of low-dose cidofovir on the long-term outcome of polyomavirus-associated nephropathy in renal transplant recipients. Nephrol. Dial. Transplant. 24, 1034\u20131038 (2009).","journal-title":"Nephrol. Dial. 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