{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:42:02Z","timestamp":1788961322274,"version":"build-2803163510"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Telocytes are interstitial cells with long, thin processes by which they contact each other and form a network in the interstitium. Myocardial remodeling of adult patients with different forms of atrial fibrillation (AF) occurs with an increase in fibrosis, age-related isolated atrial amyloidosis (IAA), cardiomyocyte hypertrophy and myolysis. This study aimed to determine the ultrastructural and immunohistochemical features of cardiac telocytes in patients with AF and AF\u2009+\u2009IAA. IAA associated with accumulation of atrial natriuretic factor was detected in 4.3\u201325% biopsies of left (LAA) and 21.7\u201341.7% of right (RAA) atrial appendage myocardium. Telocytes were identified at ultrastructural level more often in AF\u2009+\u2009IAA, than in AF group and correlated with AF duration and mitral valve regurgitation. Telocytes had ultrastructural signs of synthetic, proliferative, and phagocytic activity. Telocytes corresponded to CD117<jats:sup>+<\/jats:sup>, vimentin<jats:sup>+<\/jats:sup>, CD34<jats:sup>+<\/jats:sup>, CD44<jats:sup>+<\/jats:sup>, CD68<jats:sup>+<\/jats:sup>, CD16<jats:sup>+<\/jats:sup>, S100<jats:sup>-<\/jats:sup>, CD105<jats:sup>-<\/jats:sup> immunophenotype. No significant differences in telocytes morphology and immunophenotype were found in patients with various forms of AF. CD68-positive cells were detected more often in AF\u2009+\u2009IAA than AF group. We assume that in aged AF\u2009+\u2009IAA patients remodeling of atrial myocardium provoked transformation of telocytes into \u201ctransitional forms\u201d combining the morphological and immunohistochemical features with signs of fibroblast-, histiocyte- and endotheliocyte-like cells.<\/jats:p>","DOI":"10.1038\/s41598-021-82554-0","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T11:05:48Z","timestamp":1613041548000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Morpho-functional changes of cardiac telocytes in isolated atrial amyloidosis in patients with atrial fibrillation"],"prefix":"10.1038","volume":"11","author":[{"given":"Tatyana V.","family":"Sukhacheva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia V.","family":"Nizyaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V.","family":"Samsonova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0973-9250","authenticated-orcid":false,"given":"Andrey L.","family":"Cherniaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artem A.","family":"Burov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariia V.","family":"Iurova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandr I.","family":"Shchegolev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman A.","family":"Serov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7712-1260","authenticated-orcid":false,"given":"Gennady T.","family":"Sukhikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"82554_CR1","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/j.1582-4934.2006.tb00410.x","volume":"10","author":"LM Popescu","year":"2006","unstructured":"Popescu, L. M. et al. Insights into the interstitium of ventricular myocardium: interstitial Cajal-like cells (ICLC). J. Cell. Mol. Med. 10, 429\u2013458 (2006).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/j.1582-4934.2006.tb00306.x","volume":"10","author":"ME Hinescu","year":"2006","unstructured":"Hinescu, M. E., Gherghiceanu, M., Mandache, E., Ciontea, S. M. & Popescu, L. M. Interstitial Cajal-like cells (ICLC) in atrial myocardium: ultrastructural and immunohistochemical characterization. J. Cell. Mol. Med. 10, 243\u2013257 (2006).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR3","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1111\/j.1582-4934.2010.01111.x","volume":"14","author":"S Kostin","year":"2010","unstructured":"Kostin, S. Myocardial telocytes: a specific new cellular entity. J. Cell. Mol. Med. 14, 1917\u20131921 (2010).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR4","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1111\/j.1582-4934.2010.01133.x","volume":"14","author":"M Gherghiceanu","year":"2010","unstructured":"Gherghiceanu, M., Manole, C. G. & Popescu, L. M. Telocytes in endocardium: electron microscope evidence. J. Cell. Mol. Med. 14, 2330\u20132334 (2010).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR5","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.1111\/j.1582-4934.2010.01185.x","volume":"14","author":"L Suciu","year":"2010","unstructured":"Suciu, L., Nicolescu, M. I. & Popescu, L. M. Cardiac telocytes: serial dynamic images in cell culture. J. Cell. Mol. Med. 14, 2687\u20132692 (2010).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR6","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00441-012-1333-8","volume":"348","author":"M Gherghiceanu","year":"2012","unstructured":"Gherghiceanu, M. & Popescu, L. M. Cardiac telocytes\u2014their junctions and functional implications. Cell Tissue Res. 348, 265\u2013279 (2012).","journal-title":"Cell Tissue Res."},{"key":"82554_CR7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1582-4934.2012.01655.x","volume":"17","author":"B Zhao","year":"2013","unstructured":"Zhao, B. et al. Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat. J. Cell. Mol. Med. 17, 123\u2013133 (2013).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR8","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1111\/jcmm.12468","volume":"18","author":"D Cretoiu","year":"2014","unstructured":"Cretoiu, D., Hummel, E., Zimmermann, H., Gherghiceanu, M. & Popescu, L. M. Human cardiac telocytes: 3D imaging by FIB-SEM tomography. J. Cell. Mol. Med. 18, 2157\u20132164 (2014).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR9","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/jcmm.12509","volume":"19","author":"LM Popescu","year":"2015","unstructured":"Popescu, L. M. et al. Telocytes and putative stem cells in ageing human heart. J. Cell. Mol. Med. 19, 31\u201345 (2015).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR10","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1111\/jcmm.12615","volume":"19","author":"Q Zhou","year":"2015","unstructured":"Zhou, Q. et al. Cardiac telocytes are double positive for CD34\/PDGFR-\u03b1. J. Cell. Mol. Med. 19, 2036\u20132042 (2015).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR11","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1111\/jcmm.12815","volume":"20","author":"J Xiao","year":"2016","unstructured":"Xiao, J. et al. Telocytes in exercise-induced cardiac growth. J. Cell. Mol. Med. 20, 973\u2013979 (2016).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.aanat.2016.09.006","volume":"209","author":"MC Rusu","year":"2017","unstructured":"Rusu, M. C. et al. Subsets of telocytes: myocardial telocytes. Ann. Anat. 209, 37\u201344 (2017).","journal-title":"Ann. Anat."},{"key":"82554_CR13","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/ahe.12273","volume":"46","author":"T Vandecasteele","year":"2017","unstructured":"Vandecasteele, T. et al. Presence of ganglia and telocytes in proximity to myocardial sleeve tissue in the porcine pulmonary veins wall. Anat. Histol. Embryol. 46, 325\u2013333 (2017).","journal-title":"Anat. Histol. Embryol."},{"key":"82554_CR14","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1111\/j.1582-4934.2005.tb00387.x","volume":"9","author":"M Gherghiceanu","year":"2005","unstructured":"Gherghiceanu, M. & Popescu, L. M. Interstitial Cajal-like cells (ICLC) in human resting mammary gland stroma. Transmission electron microscope (TEM) identification. J. Cell. Mol. Med. 9, 893\u2013910 (2005).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR15","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1111\/j.1582-4934.2008.00461.x","volume":"12","author":"L Pieri","year":"2008","unstructured":"Pieri, L., Vannucchi, M. G. & Faussone-Pellegrini, M. S. Histochemical and ultrastructural characteristics of an interstitial cell type different from ICC and resident in the muscle coat of human gut. J. Cell. Mol. Med. 12, 1944\u20131955 (2008).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR16","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1111\/j.1582-4934.2008.00444.x","volume":"12","author":"M Gherghiceanu","year":"2008","unstructured":"Gherghiceanu, M. et al. Interstitial Cajal-like cells (ICLC) in myocardial sleeves of human pulmonary veins. J. Cell. Mol. Med. 12, 1777\u20131781 (2008).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR17","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.hrthm.2008.03.057","volume":"5","author":"E Morel","year":"2008","unstructured":"Morel, E., Meyronet, D., Thivolet-Bejuy, F. & Chevalier, P. Identification and distribution of interstitial Cajal cells in human pulmonary veins. Heart Rhythm. 5, 1063\u20131067 (2008).","journal-title":"Heart Rhythm."},{"key":"82554_CR18","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1111\/j.1582-4934.2011.01404.x","volume":"15","author":"Y Zheng","year":"2011","unstructured":"Zheng, Y. et al. Telocytes in tracea and lungs. J. Cell. Mol. Med. 15, 2262\u20132268 (2011).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR19","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s00441-010-1095-0","volume":"343","author":"ME Hinescu","year":"2011","unstructured":"Hinescu, M. E., Gherghiceanu, M., Suciu, L. & Popescu, L. M. Telocytes in pleura: two- and three-dimensional imaging by transmission electron microscopy. Cell Tissue Res. 343, 389\u2013397 (2011).","journal-title":"Cell Tissue Res."},{"key":"82554_CR20","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.1111\/j.1582-4934.2012.01582.x","volume":"16","author":"G Qi","year":"2012","unstructured":"Qi, G. et al. Telocytes in the human kidney cortex. J. Cell. Mol. Med. 16, 3116\u20133122 (2012).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR21","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1111\/j.1582-4934.2012.01651.x","volume":"16","author":"SM Cre\u0163oiu","year":"2012","unstructured":"Cre\u0163oiu, S. M., Cre\u0163oiu, D. & Popescu, L. M. Human myometrium\u2014the ultrastructural 3D network of telocytes. J Cell Mol Med. 16, 2844\u20132849 (2012).","journal-title":"J Cell Mol Med."},{"key":"82554_CR22","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1530\/REP-12-0369","volume":"145","author":"SM Cretoiu","year":"2013","unstructured":"Cretoiu, S. M., Cretoiu, D., Marin, A., Radu, B. M. & Popescu, L. M. Telocytes: ultrastructural, immunohistochemical and electrophysiological characteristics in human myometrium. Reproduction 145, 357\u2013370 (2013).","journal-title":"Reproduction"},{"key":"82554_CR23","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1111\/jcmm.12195","volume":"17","author":"J Xiao","year":"2013","unstructured":"Xiao, J., Wang, F., Liu, Z. & Yang, C. Telocytes in liver: electron microscopic and immunofluorescent evidence. J. Cell. Mol. Med. 17, 1537\u20131542 (2013).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR24","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1111\/jcmm.12285","volume":"18","author":"Y Yang","year":"2014","unstructured":"Yang, Y., Sun, W., Wu, S. M., Xiao, J. & Kong, X. Telocytes in human heart valves. J. Cell. Mol. Med. 18, 759\u2013765 (2014).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR25","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1111\/jcmm.12429","volume":"18","author":"M Zheng","year":"2014","unstructured":"Zheng, M. et al. Variations of chromosomes 2 and 3 gene expression profiles among pulmonary telocytes, pneumocytes, airway cells, mesenchymal stem cells and lymphocytes. J. Cell. Mol. Med. 18, 2044\u20132060 (2014).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR26","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1111\/j.1582-4934.2011.01404.x","volume":"15","author":"Y Zheng","year":"2011","unstructured":"Zheng, Y. et al. Telocytes in trachea and lungs. J. Cell. Mol. Med. 15, 2262\u20132268 (2011).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR27","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/jcmm.12228","volume":"18","author":"M Manetti","year":"2014","unstructured":"Manetti, M. et al. A loss of telocytes accompanies fibrosis of multiple organs in systemic sclerosis. J. Cell. Mol. Med. 18, 253\u2013262 (2014).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR28","doi-asserted-by":"publisher","first-page":"348","DOI":"10.4103\/0366-6999.150102","volume":"128","author":"H-O Zhang","year":"2015","unstructured":"Zhang, H.-O. et al. Morphological evidence of telocytes in mice aorta. Chin. Med. J. (Engl) 128, 348\u2013352 (2015).","journal-title":"Chin. Med. J. (Engl)"},{"key":"82554_CR29","doi-asserted-by":"publisher","first-page":"14515","DOI":"10.1038\/s41598-019-51078-z","volume":"9","author":"M Manetti","year":"2019","unstructured":"Manetti, M. et al. Morphological evidence for telocytes as stromal cells supporting satellite cell activation in eccentric contraction-induced skeletal muscle injury. Sci. Rep. 9, 14515 (2019).","journal-title":"Sci. Rep."},{"key":"82554_CR30","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/jcmm.12719","volume":"20","author":"LM Popescu","year":"2016","unstructured":"Popescu, L. M., Fertig, E. T. & Gherghiceanu, M. Reaching out: junctions between cardiac telocytes and cardiac stem cells in culture. J. Cell. Mol. Med. 20, 370\u2013380 (2016).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR31","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.jjcc.2012.01.019","volume":"60","author":"XZ He","year":"2012","unstructured":"He, X. Z. et al. Cardiomyocyte progenitors in a canine pulmonary vein model of persistent atrial fibrillation. J. Cardiol. 60, 242\u2013247 (2012).","journal-title":"J. Cardiol."},{"key":"82554_CR32","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s10517-020-04840-7","volume":"169","author":"TV Sukhacheva","year":"2020","unstructured":"Sukhacheva, T. V. et al. Telocytes in myocardium of children with congenital heart disease tetralogy of Fallot. Bull. Exp. Biol. Med. 169, 137\u2013146 (2020).","journal-title":"Bull. Exp. Biol. Med."},{"key":"82554_CR33","doi-asserted-by":"crossref","unstructured":"Zhaofu, L. & Dongqing, C. Cardiac Telocytes in Regeneration of Myocardium After Myocardial Infarction. In Telocytes. Advances in Experimental Medicine and Biology; Wang, X., Cretoiu, D., Eds.; Springer: Singapore, vol. 913, 229\u2013239 (2016).","DOI":"10.1007\/978-981-10-1061-3_15"},{"key":"82554_CR34","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1111\/j.1582-4934.2011.01449.x","volume":"15","author":"CG Manole","year":"2011","unstructured":"Manole, C. G., Cisma\u015fiu, V., Gherghiceanu, M. & Popescu, L. M. Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis. J. Cell. Mol. Med. 15, 2284\u20132296 (2011).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR35","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1111\/jcmm.12259","volume":"18","author":"B Zhao","year":"2014","unstructured":"Zhao, B. et al. Intramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post-infarcted cardiac function in rats. J. Cell. Mol. Med. 18, 780\u2013789 (2014).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR36","first-page":"5375","volume":"9","author":"J Yang","year":"2017","unstructured":"Yang, J., Li, Y., Xue, F., Liu, W. & Zhang, S. Exosomes derived from cardiac telocytes exert positive effects on endothelial cells. Am. J. Transl. Res. 9, 5375\u20135387 (2017).","journal-title":"Am. J. Transl. Res."},{"key":"82554_CR37","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1111\/j.1582-4934.2010.01119.x","volume":"14","author":"D Bani","year":"2010","unstructured":"Bani, D., Formigli, L., Gherghiceanu, M. & Faussone-Pellegrini, M. S. Telocytes as supporting cells for myocardial tissue organization in developing and adult heart. J. Cell. Mol. Med. 14, 2531\u20132538 (2010).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR38","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1111\/jcmm.12529","volume":"19","author":"VB Cisma\u015fiu","year":"2015","unstructured":"Cisma\u015fiu, V. B. & Popescu, L. M. Telocytes transfer extracellular vesicles loaded with microRNAs to stem cells. J. Cell. Mol. Med. 19, 351\u2013358 (2015).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR39","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1540-8167.2011.02187.x","volume":"23","author":"D Corradi","year":"2012","unstructured":"Corradi, D. et al. Differential structural remodeling of the left-atrial posterior wall in patients affected by mitral regurgitation with or without persistent atrial fibrillation: a morphological and molecular study. J. Cardiovasc. Electrophysiol. 23, 271\u2013279 (2012).","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"82554_CR40","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s10840-013-9820-8","volume":"38","author":"TJ van Brakel","year":"2013","unstructured":"van Brakel, T. J. et al. Fibrosis and electrophysiological characteristics of the atrial appendage in patients with atrial fibrillation and structural heart disease. J. Interv. Card. Electrophysiol. 38, 85\u201393 (2013).","journal-title":"J. Interv. Card. Electrophysiol."},{"key":"82554_CR41","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1161\/01.CIR.0000034511.06350.DF","volume":"106","author":"C R\u00f6cken","year":"2002","unstructured":"R\u00f6cken, C. et al. Atrial amyloidosis: an arrhythmogenic substrate for persistent atrial fibrillation. Circulation 106, 2091\u20132097 (2002).","journal-title":"Circulation"},{"key":"82554_CR42","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.ehj.2004.04.007","volume":"25","author":"O Leone","year":"2004","unstructured":"Leone, O. et al. Amyloid deposition as a cause of atrial remodeling in persistent valvular atrial fibrillation. Eur. Heart J. 25, 1237\u20131241 (2004).","journal-title":"Eur. Heart J."},{"key":"82554_CR43","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1111\/j.1582-4934.2010.01200.x","volume":"14","author":"E Mandache","year":"2010","unstructured":"Mandache, E., Gherghiceanu, M., Macarie, C., Kostin, S. & Popescu, L. M. Telocytes in human isolated atrial amyloidosis: ultrastructural remodeling. J. Cell. Mol. Med. 14, 2739\u20132747 (2010).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR44","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1007\/s10517-016-3324-3","volume":"160","author":"TV Sukhacheva","year":"2016","unstructured":"Sukhacheva, T. V. et al. Isolated atrial amyloidosis in patients with various types of atrial fibrillation. Bull. Exp. Biol. Med. 160, 844\u2013849 (2016).","journal-title":"Bull. Exp. Biol. Med."},{"key":"82554_CR45","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1136\/hrt.56.4.317","volume":"56","author":"GC Kaye","year":"1986","unstructured":"Kaye, G. C. et al. Isolated atrial amyloid contains atrial natriuretic peptide: a report of six cases. Br. Heart J. 56, 317\u2013320 (1986).","journal-title":"Br. Heart J."},{"key":"82554_CR46","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/S0735-1097(98)00045-X","volume":"31","author":"G Takemura","year":"1998","unstructured":"Takemura, G. et al. Expression of atrial and brain natriuretic peptides and their genes in hearts of patients with cardiac amyloidosis. J. Am. Coll. Cardiol. 31, 754\u2013765 (1998).","journal-title":"J. Am. Coll. Cardiol."},{"key":"82554_CR47","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3109\/13506129809007288","volume":"5","author":"M Takahashi","year":"1998","unstructured":"Takahashi, M. et al. Ultrastructural evidence for the formation of amyloid fibrils within cardiomyocytes in isolated atrial amyloid. Amyloid 5, 35\u201342 (1998).","journal-title":"Amyloid"},{"key":"82554_CR48","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1159\/000177950","volume":"113","author":"V Ariyarajah","year":"2009","unstructured":"Ariyarajah, V. et al. The association of atrial tachyarrhythmias with isolated atrial amyloid disease: preliminary observations in autopsied heart specimens. Cardiology 113, 132\u2013137 (2009).","journal-title":"Cardiology"},{"key":"82554_CR49","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.jjcc.2016.07.012","volume":"69","author":"J Park","year":"2017","unstructured":"Park, J. et al. High recurrence of atrial fibrillation in patients with high tissue atrial natriuretic peptide and amyloid levels after concomitant maze and mitral valve surgery. J. Cardiol. 69, 345\u2013352 (2017).","journal-title":"J. Cardiol."},{"key":"82554_CR50","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/icvts\/ivz051","volume":"29","author":"K Bhakhri","year":"2019","unstructured":"Bhakhri, K. et al. Isolated atrial amyloid: a potential contributor to morbidity and mortality following cardiac surgery. Interact. Cardiovasc. Thorac. Surg. 29, 187\u2013192 (2019).","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"82554_CR51","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1172\/JCI113872","volume":"83","author":"Y Saito","year":"1989","unstructured":"Saito, Y. et al. Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart. J. Clin. Invest. 83, 298\u2013305 (1989).","journal-title":"J. Clin. Invest."},{"key":"82554_CR52","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1161\/01.CIR.88.3.1004","volume":"88","author":"CM Wei","year":"1993","unstructured":"Wei, C. M. et al. Natriuretic peptide system in human heart failure. Circulation 88, 1004\u20131009 (1993).","journal-title":"Circulation"},{"key":"82554_CR53","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1161\/01.CIR.90.1.195","volume":"90","author":"H Yasue","year":"1994","unstructured":"Yasue, H. et al. Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure. Circulation 90, 195\u2013203 (1994).","journal-title":"Circulation"},{"key":"82554_CR54","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/S0002-9149(00)01147-4","volume":"86","author":"Yu Mizuno","year":"2000","unstructured":"Mizuno, Yu. et al. Plasma levels of A- and B-type natriuretic peptides in patients with hypertrophic cardiomyopathy or idiopathic cardiomyopathy. Am. J. Cardiol. 86, 1036\u20131040 (2000).","journal-title":"Am. J. Cardiol."},{"key":"82554_CR55","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1136\/heart.86.1.27","volume":"86","author":"II Tulevski","year":"2001","unstructured":"Tulevski, I. I. et al. Increased brain and atrial natriuretic peptides in patients with chronic right ventricular pressure overload: correlation between plasma neurohormones and right ventricular dysfunction. Heart 86, 27\u201330 (2001).","journal-title":"Heart"},{"key":"82554_CR56","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.carpath.2006.01.005","volume":"15","author":"I Steiner","year":"2006","unstructured":"Steiner, I. & H\u00e1jkov\u00e1, P. Patterns of isolated atrial amyloid: a study of 100 hearts on autopsy. Cardiovasc. Pathol. 15, 287\u2013290 (2006).","journal-title":"Cardiovasc. Pathol."},{"key":"82554_CR57","doi-asserted-by":"publisher","first-page":"43","DOI":"10.14712\/18059694.2016.88","volume":"59","author":"A Mat\u011bjkov\u00e1","year":"2016","unstructured":"Mat\u011bjkov\u00e1, A. & \u0160teiner, I. Association of atrial fibrillation with morphological and electrophysiological changes of the atrial myocardium. Acta Medica (Hradec Kralove) 59, 43\u201349 (2016).","journal-title":"Acta Medica (Hradec Kralove)"},{"key":"82554_CR58","doi-asserted-by":"publisher","first-page":"16584","DOI":"10.1038\/s41598-019-53119-z","volume":"9","author":"D Krishnappa","year":"2019","unstructured":"Krishnappa, D. et al. Atrial Fibrillation in the elderly: the role of sub-clinical isolated cardiac amyloidosis. Sci. Rep. 9, 16584 (2019).","journal-title":"Sci. Rep."},{"key":"82554_CR59","doi-asserted-by":"publisher","first-page":"53","DOI":"10.15829\/1560-4071-2019-7-53-62","volume":"7","author":"LB Mitrofanova","year":"2019","unstructured":"Mitrofanova, L. B. et al. Morphological study of telocytes in the left atrium in patients with long-term persistent atrial fibrillation. Russ. J. Cardiol. 7, 53\u201362 (2019).","journal-title":"Russ. J. Cardiol."},{"key":"82554_CR60","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1111\/jcmm.12664","volume":"19","author":"M Richter","year":"2015","unstructured":"Richter, M. & Kostin, S. The failing human heart is characterized by decreased numbers of telocytes as result of apoptosis and altered extracellular matrix composition. J. Cell. Mol. Med. 19, 2597\u20132606 (2015).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR61","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.acthis.2017.09.007","volume":"119","author":"MS Nour","year":"2017","unstructured":"Nour, M. S., Sarhan, N. R., Mazroa, S. A. & Gawish, S. A. Histological and immunohistochemical study of cardiac telocytes in a rat model of isoproterenol-induced myocardial infarction with a reference to the effect of grape seed extract. Acta Histochem. 119, 747\u2013758 (2017).","journal-title":"Acta Histochem."},{"key":"82554_CR62","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1111\/jcmm.12436","volume":"18","author":"ET Fertig","year":"2014","unstructured":"Fertig, E. T., Gherghiceanu, M. & Popescu, L. M. Extracellular vesicles release by cardiac telocytes: electron microscopy and electron tomography. J. Cell. Mol. Med. 18, 1938\u20131943 (2014).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR63","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1111\/jcmm.12624","volume":"19","author":"R Albulescu","year":"2015","unstructured":"Albulescu, R. et al. The secretome of myocardial telocytes modulates the activity of cardiac stem cells. J. Cell. Mol. Med. 19, 1783\u20131794 (2015).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR64","doi-asserted-by":"publisher","first-page":"268","DOI":"10.7150\/thno.47021","volume":"11","author":"Z Liao","year":"2021","unstructured":"Liao, Z. et al. Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cdip1 silencing to improve angiogenesis following myocardial infarction. Theranostics 11, 268\u2013291 (2021).","journal-title":"Theranostics"},{"key":"82554_CR65","doi-asserted-by":"publisher","first-page":"5360","DOI":"10.1111\/jcmm.14416","volume":"23","author":"S Li","year":"2019","unstructured":"Li, S., Shen, X. & He, S. Expression of toll-like receptorsand their regulatory roles in murine cardiactelocytes. J. Cell. Mol. Med. 23, 5360\u20135368 (2019).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR66","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1111\/jcmm.12437","volume":"18","author":"L D\u0131az-Flores","year":"2014","unstructured":"D\u0131az-Flores, L. et al. Uptake and intracytoplasmic storage of pigmented particles by human CD34+ stromal cells\/telocytes: endocytic property of telocytes. J. Cell. Mol. Med. 18, 2478\u20132487 (2014).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR67","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.phrs.2017.07.020","volume":"127","author":"AM Smits","year":"2018","unstructured":"Smits, A. M., Dronkers, E. & Goumans, M. J. The epicardium as a source of multipotent adult cardiac progenitor cells: their origin, role and fate. Pharmacol Res. 127, 129\u2013140 (2018).","journal-title":"Pharmacol Res."},{"key":"82554_CR68","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1111\/jcmm.12302","volume":"18","author":"X Sun","year":"2014","unstructured":"Sun, X. et al. Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes. J. Cell. Mol. Med. 18, 801\u2013810 (2014).","journal-title":"J. Cell. Mol. Med."},{"key":"82554_CR69","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13062-015-0042-0","volume":"10","author":"J Wang","year":"2015","unstructured":"Wang, J., Ye, L., Jin, M. & Wang, X. Global analyses of chromosome 17 and 18 genes of lung telocytes compared with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes. Biol. Direct. 10, 9 (2015).","journal-title":"Biol. Direct."},{"key":"82554_CR70","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s11010-014-2215-z","volume":"398","author":"CM Niculite","year":"2015","unstructured":"Niculite, C. M. et al. Dynamics of telopodes (telocyte prolongations) in cell culture depends on extracellular matrix protein. Mol. Cell Biochem. 398, 157\u2013164 (2015).","journal-title":"Mol. Cell Biochem."},{"key":"82554_CR71","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.yexcr.2015.08.012","volume":"338","author":"Y Chang","year":"2015","unstructured":"Chang, Y., Li, C., Lu, Z., Li, H. & Guo, Z. Multiple immunophenotypes of cardiac telocytes. Exp. Cell. Res. 338, 239\u2013244 (2015).","journal-title":"Exp. Cell. Res."},{"key":"82554_CR72","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.3390\/app9081615","volume":"9","author":"CB Iancu","year":"2019","unstructured":"Iancu, C. B., Rusu, M. C., Mogoant\u0103, L., Hostiuc, S. & Toader, O. D. The telocytes in the subepicardial niche. Appl. Sci. 9, 1615 (2019).","journal-title":"Appl. Sci."},{"key":"82554_CR73","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1046\/j.1365-2982.1999.00164.x","volume":"11","author":"KM Sanders","year":"1999","unstructured":"Sanders, K. M., Ord\u00f6g, T., Kon, S. D., Torihashi, S. & Ward, S. M. Development and plasticity of interstitial cells of Cajal. Neurogastroenterol. Motil. 11, 311\u2013338 (1999).","journal-title":"Neurogastroenterol. Motil."},{"key":"82554_CR74","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1016\/j.celrep.2014.11.002","volume":"9","author":"K Batta","year":"2014","unstructured":"Batta, K., Florkowska, M., Kouskoff, V. & Lacaud, G. Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells. Cell Rep. 9, 1871\u20131884 (2014).","journal-title":"Cell Rep."},{"key":"82554_CR75","first-page":"1","volume":"24","author":"M Litvi\u0148ukov\u00e1","year":"2020","unstructured":"Litvi\u0148ukov\u00e1, M. et al. Cells of the adult human heart. Nature 24, 1\u20137 (2020).","journal-title":"Nature"},{"key":"82554_CR76","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1161\/CIRCULATIONAHA.119.045401","volume":"142","author":"NR Tucker","year":"2020","unstructured":"Tucker, N. R. et al. Transcriptional and cellular diversity of the human heart. Circulation 142, 466\u2013482 (2020).","journal-title":"Circulation"},{"key":"82554_CR77","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1196\/annals.1389.022","volume":"1101","author":"LM Popescu","year":"2007","unstructured":"Popescu, L. M., Ciontea, S. M. & Cretoiu, D. Interstitial Cajal-like cells in human uterus and fallopian tube. Ann. NY Acad. Sci. 1101, 139\u2013165 (2007).","journal-title":"Ann. NY Acad. Sci."},{"key":"82554_CR78","doi-asserted-by":"publisher","first-page":"16029","DOI":"10.1073\/pnas.1406508111","volume":"111","author":"KJ Lavine","year":"2014","unstructured":"Lavine, K. J. et al. Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart. Proc. Natl. Acad. Sci. USA 111, 16029\u201316034 (2014).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"82554_CR79","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.cell.2017.03.050","volume":"169","author":"M Hulsmans","year":"2017","unstructured":"Hulsmans, M. et al. Macrophages facilitate electrical conduction in the heart. Cell 169, 510-522.e20 (2017).","journal-title":"Cell"},{"key":"82554_CR80","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1172\/JCI72181","volume":"124","author":"AB Aurora","year":"2014","unstructured":"Aurora, A. B. et al. Macrophages are required for neonatal heart regeneration. J. Clin. Invest. 124, 1382\u20131392 (2014).","journal-title":"J. Clin. Invest."},{"key":"82554_CR81","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.cell.2014.02.041","volume":"157","author":"AA S\u00e1nchez","year":"2014","unstructured":"S\u00e1nchez, A. A. & Yamanaka, S. Rethinking differentiation: stem cells, regeneration, and plasticity. Cell 157, 110\u2013119 (2014).","journal-title":"Cell"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-82554-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-82554-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-82554-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T03:47:23Z","timestamp":1670039243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-82554-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,11]]},"references-count":81,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["82554"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-82554-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,11]]},"assertion":[{"value":"1 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3563"}}