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We analyzed 45,076 participants, whose BMI were measured on phase 1 (2002\u20132003), phase 2 (2004\u20132005), and phase 3 (2006\u20132007), of the Korean National Health Insurance Service-Health Screening Cohort. We evaluated the effect of 2- and 4-year BMI changes and BMI variability on the risk of AD using Cox regression models. In men, association between 2-year BMI changes, BMI variability, and the risk of AD was not significant. Risk of AD was higher in men whose BMI had decreased 10.1\u201315.0% over 4\u00a0years. In women, aHRs and 95% CIs for AD were 1.14 (1.02\u20131.29), 1.44 (1.17\u20131.79), and 1.51 (1.09\u20132.09) when 2-year BMI loss was 5.1\u201310.0%, 10.1\u201315.0%, and\u2009&gt;\u200915.0%. The HRs for AD in women significantly increased when 4-year BMI loss was\u2009&gt;\u20095.0%. The aHR and 95% CI for AD was 1.31 (1.17\u20131.46) in the 4th quartile of average successive variability (ASV) compared with the 1st quartile of ASV in women. BMI loss over 2- and 4-year period was associated with increased risk for AD, and risk increased in women with higher BMI variability. Appropriate body weight management is recommended to prevent AD.<\/jats:p>","DOI":"10.1038\/s41598-021-82593-7","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T11:08:10Z","timestamp":1612436890000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Body mass index trajectories and the risk for Alzheimer\u2019s disease among older adults"],"prefix":"10.1038","volume":"11","author":[{"given":"Seo Young","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Jee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooyoung","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Young","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Soon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Sik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"82593_CR1","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1056\/NEJMra0909142","volume":"362","author":"HW Querfurth","year":"2010","unstructured":"Querfurth, H. 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