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The Smith Papyrus (2600\u2009~\u20092200 B.C.) described the use of copper surfaces to sterilize chest wounds and drinking water. Brass and bronze on doorknobs can discourage microbial spread in hospitals, and metal-base surface coatings are used in hygiene-sensitive environments, both as inactivators and modulators of cellular immunity. A limitation of these approaches is that the reactive oxygen radicals (ROS) generated at metal surfaces also damage human cells by oxidizing their proteins and lipids. Silicon nitride (Si<jats:sub>3<\/jats:sub>N<jats:sub>4<\/jats:sub>) is a non-oxide ceramic compound with known surface bacterial resistance. We show here that off-stoichiometric reactions at Si<jats:sub>3<\/jats:sub>N<jats:sub>4<\/jats:sub> surfaces are also capable of inactivating different types of single-stranded RNA (ssRNA) viruses independent of whether their structure presents an envelop or not. The antiviral property of Si<jats:sub>3<\/jats:sub>N<jats:sub>4<\/jats:sub> derives from a hydrolysis reaction at its surface and the subsequent formation of reactive nitrogen species (RNS) in doses that could be metabolized by mammalian cells but are lethal to pathogens. Real-time reverse transcription (RT)-polymerase chain reaction (PCR) tests of viral RNA and in situ Raman spectroscopy suggested that the products of Si<jats:sub>3<\/jats:sub>N<jats:sub>4<\/jats:sub> hydrolysis directly react with viral proteins and RNA. Si<jats:sub>3<\/jats:sub>N<jats:sub>4<\/jats:sub> may have a role in controlling human epidemics related to ssRNA mutant viruses.<\/jats:p>","DOI":"10.1038\/s41598-021-82608-3","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T11:10:36Z","timestamp":1612350636000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Silicon nitride: a potent solid-state bioceramic inactivator of ssRNA viruses"],"prefix":"10.1038","volume":"11","author":[{"given":"Giuseppe","family":"Pezzotti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Boschetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Ohgitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenliang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elia","family":"Marin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan J.","family":"McEntire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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