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In this study, we aimed to investigate the presence of horizontally acquired antibiotic resistance genes among chicken gut microbiota members in 259 isolates with known whole genomic sequences. Altogether 124 isolates contained at least one gene coding for antibiotic resistance. Genes coding for the resistance to tetracyclines (detected in 101 isolates), macrolide-lincosamide-streptogramin B antibiotics (28 isolates) and aminoglycosides (25 isolates) were the most common. The most frequent tetracycline resistance genes were\n                    <jats:italic>tet<\/jats:italic>\n                    (W),\n                    <jats:italic>tet<\/jats:italic>\n                    (32),\n                    <jats:italic>tet<\/jats:italic>\n                    (O) and\n                    <jats:italic>tet<\/jats:italic>\n                    (Q).\n                    <jats:italic>Lachnospiraceae<\/jats:italic>\n                    and\n                    <jats:italic>Ruminococcaceae<\/jats:italic>\n                    frequently encoded\n                    <jats:italic>tet<\/jats:italic>\n                    (W).\n                    <jats:italic>Lachnospiraceae<\/jats:italic>\n                    commonly coded also for\n                    <jats:italic>tet<\/jats:italic>\n                    (32) and\n                    <jats:italic>tet<\/jats:italic>\n                    (O). The\n                    <jats:italic>tet<\/jats:italic>\n                    (44) gene was associated with\n                    <jats:italic>Erysipelotrichaceae<\/jats:italic>\n                    and\n                    <jats:italic>tet<\/jats:italic>\n                    (Q) was detected in the genomes of\n                    <jats:italic>Bacteroidaceae<\/jats:italic>\n                    and\n                    <jats:italic>Porphyromonadaceae<\/jats:italic>\n                    . Without any bias we have shown that antibiotic resistance is quite common in gut commensals. However, a comparison of codon usage showed that the above-mentioned families represent the most common current reservoirs but probably not the original host of the detected resistances.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-82640-3","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T16:31:35Z","timestamp":1612801895000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["The distribution of antibiotic resistance genes in chicken gut microbiota commensals"],"prefix":"10.1038","volume":"11","author":[{"given":"Helena","family":"Juricova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitka","family":"Matiasovicova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Kubasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darina","family":"Cejkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Rychlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"82640_CR1","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1128\/aac.47.6.2002-2005.2003","volume":"47","author":"M Faldynova","year":"2003","unstructured":"Faldynova, M. et al. 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