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We correlated these findings with conventional indocyanine green angiography (ICGA). ICGA and SS-OCTA images were collected and analyzed of 12 eyes of 12 patients. The A-SRF was annotated and a qualitative analysis of choriocapillaris, the vessel density (VD) and perfusion density (PD) of the retinal superficial capillary plexus (SCP) and the deep capillary plexus (DCP) was performed in A-SRF and the unaffected remaining area (RA). The VD and PD in the DCP were statistically significantly lower in A-SRF than in the RA at baseline. (VD: <jats:italic>p<\/jats:italic>\u2009=\u20090.014; PD: <jats:italic>p<\/jats:italic>\u2009=\u20090.036). After 1 month, there was a statistically significant difference in the VD and PD of the DCP (VD: <jats:italic>p<\/jats:italic>\u2009=\u20090.015; PD: <jats:italic>p<\/jats:italic>\u2009=\u20090.014), and for the PD of the SCP between the A-SRF and the RA (<jats:italic>p<\/jats:italic>\u2009=\u20090.015), with lower values in the A-SRF. We found low perfused areas in choriocapillaris corresponding to hypofluorescent areas on ICGA. In conclusion there is a difference in VD and VD of the DCP in the area of SRF in acute CSC. These alterations may lead to a chronic change in the microvasculature and potentially to morphological changes<jats:bold>.<\/jats:bold><\/jats:p>","DOI":"10.1038\/s41598-021-82650-1","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T11:08:10Z","timestamp":1612436890000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early alterations in retinal microvasculature on swept-source optical coherence tomography angiography in acute central serous chorioretinopathy"],"prefix":"10.1038","volume":"11","author":[{"given":"Dominika","family":"Podkowinski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Foessl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"de Sisternes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Beka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Sophie","family":"Mursch-Edlmayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert W.","family":"Strauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Bolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"82650_CR1","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1038\/eye.2010.130","volume":"24","author":"M Gemenetzi","year":"2010","unstructured":"Gemenetzi, M., De Salvo, G. & Lotery, A. 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