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While the pathogenesis remains unknown, previous studies have implicated post-viral inflammation and resulting compression of the facial nerve. Reported heritability estimates of 4\u201314% suggest a genetic component in the etiology and an autosomal dominant inheritance has been proposed. Here, we report findings from a meta-analysis of genome-wide association studies uncovering the first unequivocal association with Bell\u2019s palsy (rs9357446-A; <jats:italic>P<\/jats:italic>\u2009=\u20096.79\u2009\u00d7\u200910<jats:sup>\u221223<\/jats:sup>, OR\u2009=\u20091.23; <jats:italic>N<\/jats:italic><jats:sub>cases<\/jats:sub>\u2009=\u20094714, <jats:italic>N<\/jats:italic><jats:sub>controls<\/jats:sub>\u2009=\u20091,011,520). The variant also confers risk of intervertebral disc disorders (<jats:italic>P<\/jats:italic>\u2009=\u20092.99\u2009\u00d7\u200910<jats:sup>\u221211<\/jats:sup>, OR\u2009=\u20091.04) suggesting a common pathogenesis in part or a true pleiotropy.<\/jats:p>","DOI":"10.1038\/s41598-021-82736-w","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T09:14:59Z","timestamp":1613812499000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A meta-analysis uncovers the first sequence variant conferring risk of Bell\u2019s palsy"],"prefix":"10.1038","volume":"11","author":[{"given":"Astros Th.","family":"Skuladottir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyda","family":"Bjornsdottir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudmar","family":"Thorleifsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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