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Here, we optically examine retinal mitochondrial function as well as choroidal oxygenation and hemodynamics in aging C57 and complement factor H (CFH\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice, proposed models of macular degeneration which suffer early retinal mitochondrial decline. In young C57s mitochondrial populations respire in coupled oscillatory behavior in cycles of ~\u20098\u00a0min, which is phase linked to choroidal oscillatory hemodynamics. In aging C57s, the oscillations are less regular being ~\u200914\u00a0min and more dissociated from choroidal hemodynamics. The mitochondrial oscillatory cycles are extended in CFH\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice being ~\u200916\u00a0min and are further dissociated from choroidal hemodynamics. Mitochondrial decline occurs before age-related changes to choroidal vasculature, hence, is the likely origin of oscillatory disruption in hemodynamics. This technology offers a non-invasive technique to detect early retinal disease and its relationship to blood oxygenation in vivo and in real time.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-82811-2","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T16:31:35Z","timestamp":1612801895000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration"],"prefix":"10.1038","volume":"11","author":[{"given":"Pardis","family":"Kaynezhad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Tachtsidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Aboelnour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sobha","family":"Sivaprasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Jeffery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"82811_CR1","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","volume":"153","author":"C L\u00f3pez-ot\u00edn","year":"2013","unstructured":"L\u00f3pez-ot\u00edn, C., Blasco, M. 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