{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:21:02Z","timestamp":1761582062476},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fecal immunochemical test (FIT) is widely used as a colorectal cancer screening tool. Antithrombotic drugs may affect the screening performance of FIT for colorectal tumors. The aim of this study was to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal neoplasms. This retrospective study enrolled a total of 758 patients who underwent both FIT and total colonoscopy. The effect of antithrombotic drugs on FIT accuracy in detecting colorectal neoplasms (CN), including colorectal cancer (CRC), advanced adenoma (AA), and non-advanced adenoma (NAA), was examined. Of the 758 patients, 144 (19%) received antithrombotic drugs (administration group). In administration group, 61\/144 (42%) cases had CN [CRC:14, AA:15, NAA:32] and 217\/614 (35%) cases had CN (CRC:43, AA:56, NAA:118) in non-administration group. The prevalence of CN was not significantly different between the two groups (p\u2009=\u20090.1157). There was no significant difference in sensitivity or specificity of the detection of all types of CN with or without taking antithrombotic drugs. Neither the positive predictive value nor negative predictive value of FIT was affected by antithrombotic drug administration. Taking antithrombotic drugs may not have a large impact on sensitivity, specificity, positive predictive value, or negative predictive value of FIT in screening for CN.<\/jats:p>","DOI":"10.1038\/s41598-021-83007-4","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T11:05:33Z","timestamp":1614078333000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening"],"prefix":"10.1038","volume":"11","author":[{"given":"Takashi","family":"Ibuka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Horibe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Mabuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Takada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Iwama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koshiro","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Arao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Takai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"issue":"5","key":"83007_CR1","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay, J. et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer. 136(5), E359\u2013E386 (2015).","journal-title":"Int. J. Cancer."},{"issue":"11","key":"83007_CR2","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1136\/gut.2007.122739","volume":"56","author":"H Brenner","year":"2007","unstructured":"Brenner, H. et al. Risk of progression of advanced adenomas to colorectal cancer by age and sex: Estimates based on 840,149 screening colonoscopies. Gut 56(11), 1585\u20131589 (2007).","journal-title":"Gut"},{"issue":"27","key":"83007_CR3","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1056\/NEJM199312303292701","volume":"329","author":"SJ Winawer","year":"1993","unstructured":"Winawer, S. J. et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N. Engl. J. Med. 329(27), 1977\u20131981 (1993).","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"83007_CR4","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.giec.2019.05.001","volume":"29","author":"CJ Kahi","year":"2019","unstructured":"Kahi, C. J. Reviewing the evidence that polypectomy prevents cancer. Gastrointest. Endosc. Clin. N. Am. 29(4), 577\u2013585 (2019).","journal-title":"Gastrointest. Endosc. Clin. N. Am."},{"issue":"10","key":"83007_CR5","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1136\/gutjnl-2014-309086","volume":"64","author":"EH Schreuders","year":"2015","unstructured":"Schreuders, E. H. et al. Colorectal cancer screening: A global overview of existing programmes. Gut 64(10), 1637\u20131649 (2015).","journal-title":"Gut"},{"issue":"1","key":"83007_CR6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/sj.bjc.6601002","volume":"89","author":"M Nakajima","year":"2003","unstructured":"Nakajima, M. et al. Prevention of advanced colorectal cancer by screening using the immunochemical faecal occult blood test: A case\u2013control study. Br. J. Cancer. 89(1), 23\u201328 (2003).","journal-title":"Br. J. Cancer."},{"issue":"5","key":"83007_CR7","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1136\/gutjnl-2017-315340","volume":"68","author":"E Wieten","year":"2019","unstructured":"Wieten, E. et al. Incidence of faecal occult blood test interval cancers in population-based colorectal cancer screening: A systematic review and meta-analysis. Gut 68(5), 873\u2013881 (2019).","journal-title":"Gut"},{"issue":"5","key":"83007_CR8","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1053\/j.gastro.2016.08.053","volume":"152","author":"DJ Robertson","year":"2017","unstructured":"Robertson, D. J. et al. Recommendations on fecal immunochemical testing to screen for colorectal neoplasia: A consensus statement by the US Multi-Society Task Force on colorectal cancer. Gastroenterology 152(5), 1217\u20131237.e3 (2017).","journal-title":"Gastroenterology"},{"issue":"5","key":"83007_CR9","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1053\/j.gastro.2017.07.034","volume":"153","author":"EJ Grobbee","year":"2017","unstructured":"Grobbee, E. J. et al. Association between concentrations of hemoglobin determined by fecal immunochemical tests and long-term development of advanced colorectal neoplasia. Gastroenterology 153(5), 1251\u20131259.e2 (2017).","journal-title":"Gastroenterology"},{"issue":"12","key":"83007_CR10","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1001\/archinte.159.12.1322","volume":"159","author":"AL Gullov","year":"1999","unstructured":"Gullov, A. L., Koefoed, B. G. & Petersen, P. Bleeding during warfarin and aspirin therapy in patients with atrial fibrillation: The AFASAK 2 study. Atrial fibrillation aspirin and anticoagulation. Arch. Intern. Med. 159(12), 1322\u20131328 (1999).","journal-title":"Arch. Intern. Med."},{"issue":"6","key":"83007_CR11","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1053\/j.gastro.2019.01.040","volume":"156","author":"KR Randel","year":"2019","unstructured":"Randel, K. R. et al. Effects of oral anticoagulants and aspirin on performance of fecal immunochemical tests in colorectal cancer screening. Gastroenterology 156(6), 1642\u20131649.e1 (2019).","journal-title":"Gastroenterology"},{"issue":"2","key":"83007_CR12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1159\/000494251","volume":"100","author":"R Niikura","year":"2019","unstructured":"Niikura, R. et al. The effects of direct oral anticoagulants, warfarin, aspirin and thienopyridine on the performance of immunochemical, faecal, occult blood tests. Digestion. 100(2), 117\u2013126 (2019).","journal-title":"Digestion."},{"issue":"4","key":"83007_CR13","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1097\/MEG.0b013e3283438aac","volume":"23","author":"G Mandelli","year":"2011","unstructured":"Mandelli, G. et al. Anticoagulant or aspirin treatment does not affect the positive predictive value of an immunological fecal occult blood test in patients undergoing colorectal cancer screening: Results from a nested in a cohort case\u2013control study. Eur. J. Gastroenterol. Hepatol. 23(4), 323\u2013326 (2011).","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"3","key":"83007_CR14","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1111\/den.12208","volume":"26","author":"Y Tsuji","year":"2014","unstructured":"Tsuji, Y. et al. Antithrombotic drug does not affect the positive predictive value of an immunochemical fecal occult blood test. Dig. Endosc. 26(3), 424\u2013429 (2014).","journal-title":"Dig. Endosc."},{"issue":"22","key":"83007_CR15","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1001\/jama.2010.1773","volume":"304","author":"H Brenner","year":"2010","unstructured":"Brenner, H., Tao, S. & Haug, U. Low-dose aspirin use and performance of immunochemical fecal occult blood tests. JAMA 304(22), 2513\u20132520 (2010).","journal-title":"JAMA"},{"issue":"17","key":"83007_CR16","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1001\/jama.2019.4755","volume":"321","author":"H Brenner","year":"2019","unstructured":"Brenner, H. et al. Effect of a single aspirin dose prior to fecal immunochemical testing on test sensitivity for detecting advanced colorectal neoplasms: A randomized clinical trial. JAMA 321(17), 1686\u20131692 (2019).","journal-title":"JAMA"},{"issue":"4","key":"83007_CR17","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/ajg.2009.14","volume":"104","author":"Z Levi","year":"2009","unstructured":"Levi, Z. et al. Sensitivity, but not specificity, of a quantitative immunochemical fecal occult blood test for neoplasia is slightly increased by the use of low-dose aspirin, NSAIDs, and anticoagulants. Am. J. Gastroenterol. 104(4), 933\u2013938 (2009).","journal-title":"Am. J. Gastroenterol."},{"issue":"5","key":"83007_CR18","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1038\/bjc.2014.38","volume":"110","author":"L Bujanda","year":"2014","unstructured":"Bujanda, L. et al. Effect of oral anticoagulants on the outcome of faecal immunochemical test. Br. J. Cancer. 110(5), 1334\u20131337 (2014).","journal-title":"Br. J. Cancer."},{"issue":"5","key":"83007_CR19","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1136\/gutjnl-2018-316344","volume":"68","author":"SAV Nieuwenburg","year":"2019","unstructured":"Nieuwenburg, S. A. V., Vuik, F. E. R., Kruip, M. J. H. A., Kuipers, E. J. & Spaander, M. C. W. Effect of anticoagulants and NSAIDs on accuracy of faecal immunochemical tests (FITs) in colorectal cancer screening: A systematic review and meta-analysis. Gut 68(5), 866\u2013872 (2019).","journal-title":"Gut"},{"issue":"27","key":"83007_CR20","first-page":"8939","volume":"20","author":"Y Shirakami","year":"2014","unstructured":"Shirakami, Y. et al. Chemoprevention of colorectal cancer by targeting obesity-related metabolic abnormalities. World J. Gastroenterol. 20(27), 8939\u20138946 (2014).","journal-title":"World J. Gastroenterol."},{"issue":"12","key":"83007_CR21","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.1002\/ijc.29343","volume":"136","author":"U Haug","year":"2015","unstructured":"Haug, U., Knudsen, A. B., Lansdorp-Vogelaar, I. & Kuntz, K. M. Development of new non-invasive tests for colorectal cancer screening: The relevance of information on adenoma detection. Int. J. Cancer. 136(12), 2864\u20132874 (2015).","journal-title":"Int. J. Cancer."},{"issue":"2","key":"83007_CR22","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/ijc.31233","volume":"143","author":"A Gies","year":"2018","unstructured":"Gies, A., Bhardwaj, M., Stock, C., Schrotz-King, P. & Brenner, H. Quantitative fecal immunochemical tests for colorectal cancer screening. Int. J. Cancer. 143(2), 234\u2013244 (2018).","journal-title":"Int. J. Cancer."},{"issue":"8","key":"83007_CR23","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1056\/NEJMoa1100370","volume":"366","author":"AG Zauber","year":"2012","unstructured":"Zauber, A. G. et al. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N. Engl. J. Med. 366(8), 687\u2013696 (2012).","journal-title":"N. Engl. J. Med."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-83007-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-83007-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-83007-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T04:01:04Z","timestamp":1670040064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-83007-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["83007"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-83007-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,23]]},"assertion":[{"value":"17 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4348"}}