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Comparisons with conventional radiotherapy have shown that IMRT is associated with lower frequencies of acute and late-onset AEs. Here, we extended a prospective, observational, single-center study of the safety of IMRT to a second investigating center. Patients scheduled for adjuvant IMRT after partial or total mastectomy were given a dose of 50\u00a0Gy (25 fractions of 2\u00a0Gy over 5\u00a0weeks), with a simultaneous integrated boost in patients having undergone conservative surgery. 300 patients were included in the study, and 288 were analyzed. The median follow-up period was 2.1\u00a0years. The 2-year disease-free survival rate [95% CI] was 93.4% [89.2\u201396.0%]. Most AEs were mild. The most common AEs were skin-related\u2014mainly radiodermatitis [in 266 patients (92.4%)] and hyperpigmentation (in 178 (61.8%)). 35% and 6% of the patients presented with grade 2 acute skin and esophageal toxicity, respectively. Only 4 patients presented with a grade 3 event (radiodermatitis). Smoking (odds ratio) [95% CI]\u2009=\u20092.10 [1.14\u20133.87]; p\u2009=\u20090.017), no prior chemotherapy (0.52 [0.27\u20130.98]; p\u2009=\u20090.044), and D98% for subclavicular skin (1.030 [1.001\u20131.061]; p\u2009=\u20090.045) were associated with grade\u2009\u2265\u20092 acute AEs. In a univariate analysis, the mean dose, (p\u2009&lt;\u20090.0001), D2% (p\u2009&lt;\u20090.0001), D50% (p\u2009=\u20090.037), D95% (p\u2009=\u20090.0005), D98% (p\u2009=\u20090.0007), V30Gy (p\u2009&lt;\u20090.0001), and V45Gy (p\u2009=\u20090.0001) were significantly associated with grade\u2009\u2265\u20091 acute esophageal AEs. In a multivariate analysis, D95% for the skin (p\u2009&lt;\u20090.001), D98% for the subclavicular skin and low D95% for the internal mammary lymph nodes were associated with grade\u2009\u2265\u20091 medium-term AEs. The safety profile of adjuvant IMRT after partial or total mastectomy is influenced by dosimetric parameters.<\/jats:p><jats:p><jats:italic>Trial registration<\/jats:italic>: ClinicalTrials.gov NCT02281149.<\/jats:p>","DOI":"10.1038\/s41598-021-83159-3","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T11:03:58Z","timestamp":1613041438000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Correlation between toxicity and dosimetric parameters for adjuvant intensity modulated radiation therapy of breast cancer: a prospective study"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6019-7309","authenticated-orcid":false,"given":"David","family":"Pasquier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit","family":"Bataille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Le Tinier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoudha","family":"Bennadji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Langin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Escande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Tresch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franck","family":"Darloy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Carlier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"Crop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Lartigau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"83159_CR1","doi-asserted-by":"crossref","unstructured":"Early Breast Cancer Trialists' Collaborative Group, et al. 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