{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:51:58Z","timestamp":1760205118656,"version":"3.37.3"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["20-71-10034","20-71-10034","20-71-10034"],"award-info":[{"award-number":["20-71-10034","20-71-10034","20-71-10034"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["19-315-90008","19-315-90008"],"award-info":[{"award-number":["19-315-90008","19-315-90008"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Type 1 diabetes is a chronic autoimmune disease that affects tens of millions of people. Diabetes mellitus is one of the strongest factors in the development of cerebrovascular diseases. In this study we used NOD.CB17 Prkdcscid mice and the pharmacological model of type 1 diabetes mellitus of different duration to study changes in the cerebral vasculature. We used two combined approaches using magnetic resonance angiography both steady and transient CFD blood flow modeling. We identified the influence of type 1 diabetes on the architectonics and hemodynamics of the large blood vessels of the brain as the disease progresses. For the first time, we detected a statistically significant change in angioarchitectonics (the angles between the vessels of the circle of Willis, cross-sections areas of vessels) and hemodynamic (maximum blood flow rate, hydraulic resistance) in animals with diabetes duration of 2\u00a0months, that is manifested by the development of asymmetry of cerebral blood flow. The result shows the negative effect of diabetes on cerebral circulation as well as the practicability of CFD modeling. This may be of extensive interest, in pharmacological and preclinical studies.<\/jats:p>","DOI":"10.1038\/s41598-021-83484-7","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T16:46:37Z","timestamp":1613753197000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration"],"prefix":"10.1038","volume":"11","author":[{"given":"Galina","family":"Yankova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darya","family":"Tur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniil","family":"Parshin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Cherevko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Akulov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"issue":"2","key":"83484_CR1","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s12016-016-8592-1","volume":"52","author":"Z Wang","year":"2016","unstructured":"Wang, Z., Xie, Z., Lu, Q., Chang, C. & Zhou, Z. Beyond genetics: what causes type 1 diabetes. Clin. Rev. Allerg. Immunol. 52(2), 273\u2013584 (2016).","journal-title":"Clin. Rev. Allerg. Immunol."},{"key":"83484_CR2","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1056\/NEJM199309303291401","volume":"329","author":"The Diabetes Control and Complications Trial Research Group","year":"1993","unstructured":"The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329, 977\u2013986 (1993).","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"83484_CR3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.4239\/wjd.v6.i1.54","volume":"6","author":"RS Xu","year":"2015","unstructured":"Xu, R. S. Pathogenesis of diabetic cerebral vascular disease complication. World J. Diabetes. 6(1), 54\u201366 (2015).","journal-title":"World J. Diabetes."},{"key":"83484_CR4","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1161\/01.RES.84.9.1085","volume":"84","author":"W Dichtl","year":"1999","unstructured":"Dichtl, W. et al. Very low-density lipoprotein activates nuclear factor-\u03baB in endothelial cells. Circ. Res. 84, 1085\u20131094 (1999).","journal-title":"Circ. Res."},{"issue":"4","key":"83484_CR5","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1172\/JCI23354","volume":"116","author":"X Du","year":"2006","unstructured":"Du, X. et al. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J. Clin. Invest. 116(4), 1071\u20131080 (2006).","journal-title":"J. Clin. Invest."},{"key":"83484_CR6","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1161\/STROKEAHA.113.002073","volume":"44","author":"Q Li","year":"2013","unstructured":"Li, Q. et al. Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size. Stroke 44, 3183\u20133188 (2013).","journal-title":"Stroke"},{"issue":"4","key":"83484_CR7","doi-asserted-by":"publisher","first-page":"H1480","DOI":"10.1152\/ajpheart.2001.280.4.H1480","volume":"280","author":"Y Li","year":"2001","unstructured":"Li, Y., Woo, V. & Bose, R. Platelet hyperactivity and abnormal Ca(2+) homeostasis in diabetes mellitus. Am. J. Physiol. Heart. Circ. Physiol. 280(4), H1480\u2013H1489 (2001).","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"83484_CR8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1089\/154041903321648225","volume":"1","author":"A Aljada","year":"2003","unstructured":"Aljada, A. Endothelium, inflammation, and diabetes. Metab. Syndr. Relat. Disord. 1, 3\u201321 (2003).","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"83484_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/792393","volume":"2010","author":"IAM van den Oever","year":"2010","unstructured":"van den Oever, I. A. M., Raterman, H. G., Nurmohamed, M. T. & Simsek, S. Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus. Med. Inflam. 2010, 1\u201315 (2010).","journal-title":"Med. Inflam."},{"key":"83484_CR10","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1172\/JCI114521","volume":"85","author":"B Tesfamariam","year":"1990","unstructured":"Tesfamariam, B., Brown, M. L., Deykin, D. & Cohen, R. A. Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta. J. Clin. Invest. 85, 929\u2013932 (1990).","journal-title":"J. Clin. Invest."},{"key":"83484_CR11","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/S0008-6363(99)00425-3","volume":"46","author":"Y Hattori","year":"2000","unstructured":"Hattori, Y. High-glucose-induced nuclear factor \u03baB activation in vascular smooth muscle cells. Cardiovasc. Res. 46, 188\u2013197 (2000).","journal-title":"Cardiovasc. Res."},{"key":"83484_CR12","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.2337\/diabetes.49.11.1939","volume":"49","author":"T Inoguchi","year":"2000","unstructured":"Inoguchi, T. et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49, 1939\u20131945 (2000).","journal-title":"Diabetes"},{"key":"83484_CR13","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.jdiacomp.2015.12.018","volume":"30","author":"CP Domingueti","year":"2016","unstructured":"Domingueti, C. P. et al. Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications. J. Diabet. Compl. 30, 738\u2013745 (2016).","journal-title":"J. Diabet. Compl."},{"key":"83484_CR14","first-page":"133","volume-title":"Atlas of Human Anatomy","author":"FH Netter","year":"2003","unstructured":"Netter, F. H. Atlas of Human Anatomy 3rd edn, 133 (Icon Learning Systems, New Jersey, 2003).","edition":"3"},{"key":"83484_CR15","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1002\/cnm.2663","volume":"30","author":"TW Peach","year":"2014","unstructured":"Peach, T. W., Ngoepe, M., Spranger, K., Zajarias-Fainsod, D. & Ventikos, Y. Personalizing flow-diverter intervention for cerebral aneurysms: from computational hemodynamics to biochemical modeling. Int. J. Numer. Meth. Biomed. Eng. 30, 1387\u20131407 (2014).","journal-title":"Int. J. Numer. Meth. Biomed. Eng."},{"key":"83484_CR16","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00062-017-0640-6","volume":"29","author":"P Machi","year":"2017","unstructured":"Machi, P. et al. Hemodynamics of focal versus global growth of small cerebral aneurysms. Clin. Neuroradiol. 29, 285\u2013293 (2017).","journal-title":"Clin. Neuroradiol."},{"key":"83484_CR17","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1007\/s10237-018-1056-1","volume":"17","author":"S Bahrami","year":"2018","unstructured":"Bahrami, S. & Norouzi, M. A numerical study on hemodynamics in the left coronary bifurcation with normal and hypertension conditions. Biomech. Model Mechanobiol. 17, 1785\u20131796 (2018).","journal-title":"Biomech. Model Mechanobiol."},{"key":"83484_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep25465","volume":"6","author":"Y Togashi","year":"2016","unstructured":"Togashi, Y. et al. Evaluation of the appropriateness of using glucometers for measuring the blood glucose levels in mice. Sci. Rep. 6, 1\u20139 (2016).","journal-title":"Sci. Rep."},{"key":"83484_CR19","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jneumeth.2017.07.003","volume":"289","author":"G Pastor","year":"2017","unstructured":"Pastor, G. et al. A general protocol of ultra-high resolution MR angiography to image the cerebro-vasculature in 6 different rats strains at high field. J. Neurosci. Methods 289, 75\u201384 (2017).","journal-title":"J. Neurosci. Methods"},{"key":"83484_CR20","unstructured":"CIBC. Seg3D: Volumetric Image Segmentation and Visualization. Scientific Computing and Imaging Institute (SCI) (2016). http:\/\/www.seg3d.org."},{"key":"83484_CR21","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","volume":"31","author":"PA Yushkevich","year":"2006","unstructured":"Yushkevich, P. A. et al. User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. NeuroImage 31, 1116\u20131128 (2006).","journal-title":"NeuroImage"},{"key":"83484_CR22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00723-015-0726-8","volume":"47","author":"SV Maltseva","year":"2015","unstructured":"Maltseva, S. V. et al. Reconstruction of complex vasculature by varying the slope of the scan plane in high-field magnetic resonance imaging. Appl. Magn. Reson. 47, 23\u201339 (2015).","journal-title":"Appl. Magn. Reson."},{"key":"83484_CR23","doi-asserted-by":"crossref","unstructured":"Boiko, A.V. et al. Time-resolved Volumetric MRI Velocimetry of Periodic Flow in a Carotid Bifurcation (the model study). Magn. Reson. Mater. Phys., Biol. Med. (MAGMA). 28(S1), s384-s385 (2015).","DOI":"10.1007\/s10334-014-0476-x"},{"key":"83484_CR24","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1134\/S0021894417020031","volume":"58","author":"AV Boiko","year":"2017","unstructured":"Boiko, A. V. et al. Measurement of viscous flow velocity and flow visualization using two magnetic resonance imagers. J. Appl. Mech. Tech. Phys. 58, 209\u2013213 (2017).","journal-title":"J. Appl. Mech. Tech. Phys."},{"key":"83484_CR25","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.jbiomech.2013.09.033","volume":"47","author":"AJ Geers","year":"2014","unstructured":"Geers, A. J., Larrabide, I., Morales, H. G. & Frangi, A. F. Approximating hemodynamics of cerebral aneurysms with steady flow simulations. J. Biomech. 47, 178\u2013185 (2014).","journal-title":"J. Biomech."},{"key":"83484_CR26","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s11517-016-1541-6","volume":"55","author":"T Otani","year":"2016","unstructured":"Otani, T. et al. Computational study for the effects of coil configuration on blood flow characteristics in coil-embolized cerebral aneurysm. Med. Biol. Eng. Comput. 55, 697\u2013710 (2016).","journal-title":"Med. Biol. Eng. Comput."},{"key":"83484_CR27","doi-asserted-by":"publisher","unstructured":"Aslanidou, L. A 1D model of the arterial circulation in mice. ALTEX 13\u201328 (2016). https:\/\/doi.org\/10.14573\/altex.1507071.","DOI":"10.14573\/altex.1507071"},{"key":"83484_CR28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.aca.2015.02.012","volume":"879","author":"PS Gromski","year":"2015","unstructured":"Gromski, P. S. et al. A tutorial review: Metabolomics and partial least squares-discriminant analysis\u2013a marriage of convenience or a shotgun wedding. Anal. Chim. Acta 879, 10\u201323 (2015).","journal-title":"Anal. Chim. Acta"},{"key":"83484_CR29","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/cem.2609","volume":"28","author":"RG Brereton","year":"2014","unstructured":"Brereton, R. G. & Lloyd, G. R. Partial least squares discriminant analysis: taking the magic away. J. Chemometr. 28, 213\u2013225 (2014).","journal-title":"J. Chemometr."},{"key":"83484_CR30","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1113\/EP086064","volume":"102","author":"AA Seryapina","year":"2017","unstructured":"Seryapina, A. A., Shevelev, O. B., Moshkin, M. P., Markel, A. L. & Akulov, A. E. Stress-sensitive arterial hypertension, haemodynamic changes and brain metabolites in hypertensive ISIAH rats: MRI investigation. Exp. Physiol. 102, 523\u2013532 (2017).","journal-title":"Exp. Physiol."},{"key":"83484_CR31","doi-asserted-by":"publisher","first-page":"E1289","DOI":"10.1073\/pnas.1710329115","volume":"115","author":"RE Bennett","year":"2018","unstructured":"Bennett, R. E. et al. Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer\u2019s disease. Proc. Natl. Acad. Sci. USA 115, E1289\u2013E1298 (2018).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"83484_CR32","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.neurobiolaging.2018.06.017","volume":"70","author":"Y Li","year":"2018","unstructured":"Li, Y. et al. Aging-associated changes in cerebral vasculature and blood flow as determined by quantitative optical coherence tomography angiography. Neurobiol. Aging 70, 148\u2013159 (2018).","journal-title":"Neurobiol. Aging"},{"key":"83484_CR33","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1111\/j.1463-1326.2007.00670.x","volume":"9","author":"AJ Krentz","year":"2007","unstructured":"Krentz, A. J., Clough, G. & Byrne, C. D. Interactions between microvascular and macrovascular disease in diabetes: pathophysiology and therapeutic implications. Diabetes Obes. Metab. 9, 781\u2013791 (2007).","journal-title":"Diabetes Obes. Metab."},{"key":"83484_CR34","doi-asserted-by":"crossref","unstructured":"Kennedy McConnell, F. & Payne, S. The dual role of cerebral autoregulation and collateral flow in the circle of willis after major vessel occlusion. IEEE Trans. Biomed. Eng. 64, 1793\u20131802 (2017).","DOI":"10.1109\/TBME.2016.2623710"},{"key":"83484_CR35","doi-asserted-by":"publisher","DOI":"10.7860\/jcdr\/2013\/6580.3563","author":"S Iqbal","year":"2013","unstructured":"Iqbal, S. A comprehensive study of the anatomical variations of the circle of willis in adult human brains. JCDR https:\/\/doi.org\/10.7860\/jcdr\/2013\/6580.3563 (2013).","journal-title":"JCDR"},{"key":"83484_CR36","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/labinvest.3780331","volume":"81","author":"MH Moghadasian","year":"2001","unstructured":"Moghadasian, M. H., Frohlich, J. J. & McManus, B. M. Advances in experimental dyslipidemia and atherosclerosis. Lab. Invest. 81, 1173\u20131183 (2001).","journal-title":"Lab. Invest."},{"key":"83484_CR37","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/jcu.20233","volume":"34","author":"L Kerenyi","year":"2006","unstructured":"Kerenyi, L., Mihalka, L., Csiba, L., Bacso, H. & Bereczki, D. Role of hyperlipidemia in atherosclerotic plaque formation in the internal carotid artery. J. Clin. Ultrasound 34, 283\u2013288 (2006).","journal-title":"J. Clin. Ultrasound"},{"key":"83484_CR38","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s11684-013-0264-4","volume":"7","author":"Z Zhu","year":"2013","unstructured":"Zhu, Z., Wang, P. & Ma, S. Metabolic hypertension: concept and practice. Front. Med. 7, 201\u2013206 (2013).","journal-title":"Front. Med."},{"key":"83484_CR39","doi-asserted-by":"publisher","first-page":"2949","DOI":"10.2337\/diacare.26.10.2949","volume":"26","author":"DSH Bell","year":"2003","unstructured":"Bell, D. S. H. Diabetic cardiomyopathy. Diabetes Care 26, 2949\u20132951 (2003).","journal-title":"Diabetes Care"},{"key":"83484_CR40","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1159\/000487690","volume":"45","author":"Y Zhou","year":"2018","unstructured":"Zhou, Y. et al. Type I diabetic akita mouse model is characterized by abnormal cardiac deformation during early stages of diabetic cardiomyopathy with speckle-tracking based strain imaging. Cell Physiol. Biochem. 45, 1541\u20131550 (2018).","journal-title":"Cell Physiol. Biochem."},{"key":"83484_CR41","doi-asserted-by":"publisher","first-page":"e0187596","DOI":"10.1371\/journal.pone.0187596","volume":"12","author":"M Braig","year":"2017","unstructured":"Braig, M. et al. Preclinical 4D-flow magnetic resonance phase contrast imaging of the murine aortic arch. PLoS ONE 12, e0187596 (2017).","journal-title":"PLoS ONE"},{"key":"83484_CR42","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1017\/S0006323197005082","volume":"72","author":"R Thornhill","year":"1997","unstructured":"Thornhill, R. & M\u00f8ller, A. P. Developmental stability, disease and medicine. Biol. Rev. 72, 497\u2013548 (1997).","journal-title":"Biol. Rev."},{"key":"83484_CR43","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00431-008-0686-1","volume":"167","author":"J Nuysink","year":"2008","unstructured":"Nuysink, J., van Haastert, I. C., Takken, T. & Helders, P. J. M. Symptomatic asymmetry in the first six months of life: differential diagnosis. Eur. J. Pediatr. 167, 613\u2013619 (2008).","journal-title":"Eur. J. Pediatr."},{"key":"83484_CR44","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0161-6420(90)32488-0","volume":"97","author":"JS Duker","year":"1990","unstructured":"Duker, J. S., Brown, G. C., Bosley, T. M., Colt, C. A. & Reber, R. Asymmetric proliferative diabetic retinopathy and carotid artery disease. Ophthalmology 97, 869\u2013874 (1990).","journal-title":"Ophthalmology"},{"key":"83484_CR45","first-page":"49","volume":"2","author":"NS Rakate","year":"2014","unstructured":"Rakate, N. S. & Zambare, B. R. Fingertip patterns: a diagnostic tool to predict diabetes mellitus. Natl. J. Med. Dent. Res. 2, 49\u201353 (2014).","journal-title":"Natl. J. Med. Dent. Res."},{"key":"83484_CR46","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.21608\/mjcu.2019.53376","volume":"87","author":"I Malak","year":"2019","unstructured":"Malak, I. & El-Shazly, M. D. Asymmetric diabetic retinopathy and carotid insufficiency: a correlative study. Med. J. Cairo Univ. 87, 1331\u20131335 (2019).","journal-title":"Med. J. Cairo Univ."},{"key":"83484_CR47","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1177\/1932296816629984","volume":"10","author":"MR Morris","year":"2016","unstructured":"Morris, M. R., Ludwar, BCh., Swingle, E., Mamo, M. N. & Shubrook, J. H. A new method to assess asymmetry in fingerprints could be used as an early indicator of type 2 diabetes mellitus. J. Diabetes Sci. Technol. 10, 864\u2013871 (2016).","journal-title":"J. Diabetes Sci. Technol."},{"key":"83484_CR48","doi-asserted-by":"crossref","unstructured":"Raghavendra, Shirol, V., Dixit, D., Reddy, Y. A. K. & Desai, S. Circle of willis and its variations; morphometric study in adult human cadavers. Int. J. Med. Res. Health Sci. 3, 394 (2014).","DOI":"10.5958\/j.2319-5886.3.2.081"},{"key":"83484_CR49","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1001\/archneurpsyc.1959.02340160007002","volume":"81","author":"BJ Alpers","year":"1959","unstructured":"Alpers, B. J. Anatomical studies of the circle of Willis in normal brain. Arch. NeurPsych 81, 409 (1959).","journal-title":"Arch. NeurPsych"},{"issue":"3","key":"83484_CR50","first-page":"419","volume":"133","author":"S Kamath","year":"1981","unstructured":"Kamath, S. Observations on the length and diameter of vessel forming the circle of Willis. J. Anat. 133(3), 419\u2013423 (1981).","journal-title":"J. Anat."},{"key":"83484_CR51","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1093\/cvr\/cvr300","volume":"93","author":"S Shantikumar","year":"2011","unstructured":"Shantikumar, S., Caporali, A. & Emanueli, C. Role of microRNAs in diabetes and its cardiovascular complications. Cardiovasc. Res. 93, 583\u2013593 (2011).","journal-title":"Cardiovasc. Res."},{"key":"83484_CR52","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1161\/CIRCRESAHA.111.247445","volume":"110","author":"A Zampetaki","year":"2012","unstructured":"Zampetaki, A. & Mayr, M. MicroRNAs in vascular and metabolic disease. Circ. Res. 110, 508\u2013522 (2012).","journal-title":"Circ. Res."},{"key":"83484_CR53","unstructured":"Idelchik IE. Handbook of Hydraulic Resistance, 3th ed. (New York, Hemisphere, 1986)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-83484-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-83484-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-83484-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T14:00:17Z","timestamp":1698674417000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-83484-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["83484"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-83484-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"assertion":[{"value":"17 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3969"}}