{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:16:13Z","timestamp":1770743773876,"version":"3.49.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 from the Taiwan UTUC registry. The inclusion criteria were low stage UTUC in RNU and all cases in endoscopic managed UTUC with a curative intent. The demographic and clinical characteristics were included for analysis. In total, 84 cases in the endoscopic group and 272 cases in the RNU group were enrolled for final analysis. The median follow-up period were 33.5 and 42.0\u00a0months in endoscopic and RNU group, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.082). Comparison of Kaplan\u2013Meier estimated survival curves between groups, the endoscopic group was associated with similar overall survival (OS), cancer specific survival (CSS), and intravesical recurrence free survival (IVRS) but demonstrated inferior disease free survival (DFS) (<jats:italic>p<\/jats:italic>\u2009=\u20090.188 for OS, <jats:italic>p<\/jats:italic>\u2009=\u20090.493 for CSS and <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for DFS). Endoscopic management of UTUC was as safe as RNU in UTUC endemic region.<\/jats:p>","DOI":"10.1038\/s41598-021-83495-4","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T16:46:37Z","timestamp":1613753197000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region"],"prefix":"10.1038","volume":"11","author":[{"given":"Yung-Tai","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Chin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Chih","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang-Ying","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Hong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Khun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hao","family":"Kuei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Chang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Yuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng Kuang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao Chou","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"issue":"1","key":"83495_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.eururo.2017.07.036","volume":"73","author":"M Roupret","year":"2018","unstructured":"Roupret, M. et al. European Association of Urology Guidelines on upper urinary tract urothelial carcinoma: 2017 update. Eur. Urol. 73(1), 111\u2013122 (2018).","journal-title":"Eur. Urol."},{"issue":"12","key":"83495_CR2","first-page":"1148","volume":"46","author":"M Miyake","year":"2016","unstructured":"Miyake, M. et al. Changes in oncological outcomes after radical nephroureterectomy in patients with upper urinary tract urothelial carcinoma treated in the last two decades: A retrospective analysis based on a multicenter collaborative study. Jpn. J. Clin. Oncol. 46(12), 1148\u20131155 (2016).","journal-title":"Jpn. J. Clin. Oncol."},{"issue":"5","key":"83495_CR3","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/S0022-5347(05)67019-X","volume":"164","author":"JJ Munoz","year":"2000","unstructured":"Munoz, J. J. & Ellison, L. M. Upper tract urothelial neoplasms: Incidence and survival during the last 2 decades. J. Urol. 164(5), 1523\u20131525 (2000).","journal-title":"J. Urol."},{"issue":"5","key":"83495_CR4","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/S0090-4295(02)01529-7","volume":"59","author":"MH Yang","year":"2002","unstructured":"Yang, M. H. et al. Unusually high incidence of upper urinary tract urothelial carcinoma in Taiwan. Urology 59(5), 681\u2013687 (2002).","journal-title":"Urology"},{"issue":"6","key":"83495_CR5","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1002\/(SICI)1097-0142(19990315)85:6<1342::AID-CNCR17>3.0.CO;2-B","volume":"85","author":"YH Chou","year":"1999","unstructured":"Chou, Y. H. & Huang, C. H. Unusual clinical presentation of upper urothelial carcinoma in Taiwan. Cancer 85(6), 1342\u20131344 (1999).","journal-title":"Cancer"},{"issue":"1","key":"83495_CR6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel, R. L., Miller, K. D. & Jemal, A. Cancer statistics, 2019. CA Cancer J. Clin. 69(1), 7\u201334 (2019).","journal-title":"CA Cancer J. Clin."},{"key":"83495_CR7","unstructured":"Health Promotion Administration, Ministry of Health and Welfare. Taiwan Cancer Registry Annual Report. (2016)."},{"key":"83495_CR8","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.urology.2016.05.033","volume":"95","author":"G Vemana","year":"2016","unstructured":"Vemana, G., Kim, E. H., Bhayani, S. B., Vetter, J. M. & Strope, S. A. Survival comparison between endoscopic and surgical management for patients with upper tract urothelial cancer: A matched propensity score analysis using surveillance, epidemiology and end results-medicare data. Urology 95, 115\u2013120 (2016).","journal-title":"Urology"},{"issue":"5","key":"83495_CR9","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.juro.2015.11.036","volume":"195","author":"T Seisen","year":"2016","unstructured":"Seisen, T. et al. Oncologic outcomes of kidney sparing surgery versus radical nephroureterectomy for the elective treatment of clinically organ confined upper tract urothelial carcinoma of the distal ureter. J. Urol. 195(5), 1354\u20131361 (2016).","journal-title":"J. Urol."},{"issue":"12","key":"83495_CR10","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1016\/j.ejso.2014.06.007","volume":"40","author":"R Yakoubi","year":"2014","unstructured":"Yakoubi, R. et al. Radical nephroureterectomy versus endoscopic procedures for the treatment of localised upper tract urothelial carcinoma: A meta-analysis and a systematic review of current evidence from comparative studies. Eur. J. Surg. Oncol. 40(12), 1629\u20131634 (2014).","journal-title":"Eur. J. Surg. Oncol."},{"issue":"1","key":"83495_CR11","first-page":"21","volume":"16","author":"F Suriano","year":"2014","unstructured":"Suriano, F. & Brancato, T. Nephron-sparing management of upper tract urothelial carcinoma. Rev. Urol. 16(1), 21\u201328 (2014).","journal-title":"Rev. Urol."},{"issue":"6","key":"83495_CR12","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1016\/j.juro.2012.12.006","volume":"189","author":"ML Cutress","year":"2013","unstructured":"Cutress, M. L. et al. Endoscopic versus laparoscopic management of noninvasive upper tract urothelial carcinoma: 20-year single center experience. J. Urol. 189(6), 2054\u20132060 (2013).","journal-title":"J. Urol."},{"issue":"3","key":"83495_CR13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1089\/end.2010.0276","volume":"25","author":"EM Raymundo","year":"2011","unstructured":"Raymundo, E. M. et al. Third prize: The role of endoscopic nephron-sparing surgery in the management of upper tract urothelial carcinoma. J. Endourol. 25(3), 377\u2013384 (2011).","journal-title":"J. Endourol."},{"issue":"6","key":"83495_CR14","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1016\/j.juro.2010.02.005","volume":"183","author":"AJ Gadzinski","year":"2010","unstructured":"Gadzinski, A. J., Roberts, W. W., Faerber, G. J. & Wolf, J. S. Jr. Long-term outcomes of nephroureterectomy versus endoscopic management for upper tract urothelial carcinoma. J. Urol. 183(6), 2148\u20132153 (2010).","journal-title":"J. Urol."},{"issue":"4","key":"83495_CR15","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s12094-012-0800-8","volume":"14","author":"S Bing-bing","year":"2012","unstructured":"Bing-bing, S. et al. Correlation between surgical modality and clinicopathologic characteristics for ureteral transitional cell carcinoma. Clin. Transl. Oncol. 14(4), 312\u2013316 (2012).","journal-title":"Clin. Transl. Oncol."},{"issue":"6","key":"83495_CR16","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.eururo.2016.07.014","volume":"70","author":"T Seisen","year":"2016","unstructured":"Seisen, T. et al. Oncologic outcomes of kidney-sparing surgery versus radical nephroureterectomy for upper tract urothelial carcinoma: A systematic review by the EAU non-muscle invasive bladder cancer guidelines panel. Eur. Urol. 70(6), 1052\u20131068 (2016).","journal-title":"Eur. Urol."},{"issue":"2","key":"83495_CR17","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/bju.12341","volume":"114","author":"J Simhan","year":"2014","unstructured":"Simhan, J. et al. Nephron-sparing management versus radical nephroureterectomy for low- or moderate-grade, low-stage upper tract urothelial carcinoma. BJU Int. 114(2), 216\u2013220 (2014).","journal-title":"BJU Int."},{"issue":"1","key":"83495_CR18","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1681\/ASN.2017020136","volume":"29","author":"JT Leppert","year":"2018","unstructured":"Leppert, J. T. et al. Incident CKD after radical or partial nephrectomy. J. Am. Soc. Nephrol. 29(1), 207\u2013216 (2018).","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"83495_CR19","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/bju.13935","volume":"120","author":"M Marchioni","year":"2017","unstructured":"Marchioni, M. et al. Impact of diagnostic ureteroscopy on intravesical recurrence in patients undergoing radical nephroureterectomy for upper tract urothelial cancer: A systematic review and meta-analysis. BJU Int. 120(3), 313\u2013319 (2017).","journal-title":"BJU Int."},{"issue":"1","key":"83495_CR20","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1016\/j.clgc.2015.07.008","volume":"14","author":"JK Lee","year":"2016","unstructured":"Lee, J. K. et al. Correlation between the timing of diagnostic ureteroscopy and intravesical recurrence in upper tract urothelial cancer. Clin. Genitourin. Cancer 14(1), e37-41 (2016).","journal-title":"Clin. Genitourin. Cancer"},{"issue":"7","key":"83495_CR21","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.urolonc.2014.01.022","volume":"32","author":"H Yuan","year":"2014","unstructured":"Yuan, H. et al. Risk factors for intravesical recurrence after radical nephroureterectomy for upper tract urothelial carcinoma: A meta-analysis. Urol. Oncol. 32(7), 989\u20131002 (2014).","journal-title":"Urol. Oncol."},{"issue":"6","key":"83495_CR22","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.eururo.2014.11.035","volume":"67","author":"T Seisen","year":"2015","unstructured":"Seisen, T. et al. A systematic review and meta-analysis of clinicopathologic factors linked to intravesical recurrence after radical nephroureterectomy to treat upper tract urothelial carcinoma. Eur. Urol. 67(6), 1122\u20131133 (2015).","journal-title":"Eur. Urol."},{"issue":"1","key":"83495_CR23","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s12957-018-1411-9","volume":"16","author":"HY Lee","year":"2018","unstructured":"Lee, H. Y. et al. The diagnostic ureteroscopy before radical nephroureterectomy in upper urinary tract urothelial carcinoma is not associated with higher intravesical recurrence. World J. Surg. Oncol. 16(1), 135 (2018).","journal-title":"World J. Surg. Oncol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-83495-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-83495-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-83495-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T04:01:09Z","timestamp":1670040069000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-83495-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["83495"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-83495-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"assertion":[{"value":"11 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4040"}}