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Effective prevention of peri-implantitis may be possible by removing streptococci as target. This study aimed to evaluate the effects of 2% NaF on the prevention of streptococcal adhesion to CpTi and TZP. After immersion in 2% NaF for 90\u00a0min, surface characterization of mirror-polished CpTi and TZP disks were assesed using XPS, EPMA, and SEM. <jats:italic>S. sanguinis<\/jats:italic>, <jats:italic>S. gordonii<\/jats:italic>, and <jats:italic>S. oralis<\/jats:italic> were used as the streptococcal bacterial strains. After 24\u00a0h culture, bacterial adhesion was evaluated using an ATP-bioluminescent assay and SEM. In XPS, EPMA, and SEM analyses, fluoride was detected on the CpTi and TZP surfaces after 2% NaF immersion with no signs of localization, and no corrosion on the CpTi disks. Based on the adhesion assay, the adherences of <jats:italic>S. sanguinis<\/jats:italic>, <jats:italic>S. gordonii<\/jats:italic>, and <jats:italic>S. oralis<\/jats:italic> were significantly lower with NaF than without NaF in CpTi (<jats:italic>p<\/jats:italic>\u2009=\u20090.005, 0.001, and 0.001, respectively) and TZP (<jats:italic>p<\/jats:italic>\u2009=\u20090.003, 0.002, and 0.001). This was also confirmed by SEM. In conclusion, 2% NaF reduced the adhesion of streptococci to the CpTi and TZP surfaces.<\/jats:p>","DOI":"10.1038\/s41598-021-84096-x","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T11:03:35Z","timestamp":1614164615000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of 2% sodium fluoride solution on the prevention of streptococcal adhesion to titanium and zirconia surfaces"],"prefix":"10.1038","volume":"11","author":[{"given":"Yukari","family":"Oda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Furuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taichi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Yoshinari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutomo","family":"Yajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"84096_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1600-0757.2006.00187.x","volume":"42","author":"PE Kolenbrander","year":"2006","unstructured":"Kolenbrander, P. 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