{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:18:54Z","timestamp":1790745534657,"version":"4.1.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"International Vaccine Institute"},{"DOI":"10.13039\/100004441","name":"Swedish International Development Cooperation Agency","doi-asserted-by":"crossref","award":["5410054"],"award-info":[{"award-number":["5410054"]}],"id":[{"id":"10.13039\/100004441","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials. Antimicrobial resistance (AMR) patterns of WHO PPL in a tertiary health care facility in Southern India were explored to understand the local priority pathogens. Culture reports of laboratory specimens collected between 1st January 2014 and 31st October 2019 from paediatric patients were extracted. The antimicrobial susceptibility patterns for selected antimicrobials on the WHO PPL were analysed and reported. Of 12,256 culture specimens screened, 2335 (19%) showed culture positivity, of which 1556 (66.6%) were organisms from the WHO-PPL.\n                    <jats:italic>E. coli<\/jats:italic>\n                    was the most common organism isolated (37%), followed by\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (16%). Total of 72% of\n                    <jats:italic>E. coli<\/jats:italic>\n                    were extended-spectrum beta-lactamases (ESBL) producers, 55% of\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    were resistant to 3rd generation cephalosporins due to ESBL, and 53% of\n                    <jats:italic>Staph. aureus<\/jats:italic>\n                    were Methicillin-resistant. The analysis showed AMR trends and prevalence patterns in the study setting and the WHO-PPL document are not fully comparable. This kind of local priority difference needs to be recognised in local policies and practices.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-84293-8","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T06:03:59Z","timestamp":1614837839000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India"],"prefix":"10.1038","volume":"11","author":[{"given":"Vijayalaxmi V.","family":"Mogasale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Saldanha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. D.","family":"Rekha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittal","family":"Mogasale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"84293_CR1","unstructured":"WHO. Antimicrobial resistance2018 October 13, 2019. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antimicrobial-resistance. Accessed 13 Oct 2019."},{"key":"84293_CR2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3389\/fpubh.2014.00145","volume":"2","author":"CA Michael","year":"2014","unstructured":"Michael, C. A., Dominey-Howes, D. & Labbate, M. The antimicrobial resistance crisis: Causes, consequences, and management. Front. Public Health. 2, 145 (2014).","journal-title":"Front. Public Health."},{"key":"84293_CR3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.mib.2019.03.001","volume":"51","author":"AJ Trotter","year":"2019","unstructured":"Trotter, A. J., Aydin, A., Strinden, M. J. & O\u2019Grady, J. Recent and emerging technologies for the rapid diagnosis of infection and antimicrobial resistance. Curr. Opin. Microbiol. 51, 39\u201345 (2019).","journal-title":"Curr. Opin. Microbiol."},{"key":"84293_CR4","unstructured":"O\u2019Neill J. Review on Antimicrobial Resistance. Tackling drug Resistant Infections Globally: Final Report and Recommendations2016 October 13, 2019. https:\/\/amr-review.org\/sites\/default\/files\/160518_Final%20paper_with%20cover.pdf. Accessed 13 Oct 2019."},{"key":"84293_CR5","unstructured":"WHO. Global action plan on antimicrobial resistance2015 October 13, 2019. http:\/\/www.who.int\/antimicrobial-resistance\/global-action-plan\/en\/. Accessed 13 Oct 2019."},{"key":"84293_CR6","unstructured":"WHO. Prioritization of pathogens to guide discovery, research and development of new antibiotics for drug resistant bacterial infections, including tuberculosis 2017 October 13, 2019. https:\/\/www.who.int\/medicines\/areas\/rational_use\/prioritization-of-pathogens\/en\/. Accessed 13 Oct 2019."},{"issue":"3","key":"84293_CR7","doi-asserted-by":"publisher","first-page":"e1001974","DOI":"10.1371\/journal.pmed.1001974","volume":"13","author":"R Laxminarayan","year":"2016","unstructured":"Laxminarayan, R. & Chaudhury, R. R. Antibiotic resistance in india: Drivers and opportunities for action. PLoS Med. 13(3), e1001974 (2016).","journal-title":"PLoS Med."},{"key":"84293_CR8","unstructured":"Ganguly N. Situation Analysis: Antibiotic Use and Resistance in India 2011 October 13, 2019. https:\/\/cddep.org\/wp-content\/uploads\/2017\/06\/india-report-web_8.pdf. Accessed 13 Oct 2019."},{"issue":"2","key":"84293_CR9","doi-asserted-by":"publisher","first-page":"286","DOI":"10.4103\/0976-9668.116970","volume":"4","author":"SG Kumar","year":"2013","unstructured":"Kumar, S. G. et al. Antimicrobial resistance in India: A review. J. Nat. Sci. Biol. Med. 4(2), 286\u2013291 (2013).","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"84293_CR10","doi-asserted-by":"publisher","first-page":"j2687","DOI":"10.1136\/bmj.j2687","volume":"358","author":"M Kakkar","year":"2017","unstructured":"Kakkar, M., Walia, K., Vong, S., Chatterjee, P. & Sharma, A. Antibiotic resistance and its containment in India. BMJ 358, j2687 (2017).","journal-title":"BMJ"},{"key":"84293_CR11","unstructured":"National Action Plan on Antimicrobial Resistance (NAP-AMR) 2017\u20132021. http:\/\/www.searo.who.int\/india\/topics\/antimicrobial_resistance\/nap_amr.pdf. Accessed 13 Oct 2019."},{"issue":"2","key":"84293_CR12","doi-asserted-by":"publisher","first-page":"164","DOI":"10.4103\/ijmr.IJMR_226_18","volume":"149","author":"K Walia","year":"2019","unstructured":"Walia, K. et al. Establishing antimicrobial resistance surveillance & research network in india: Journey so far. Indian J. Med. Res. 149(2), 164\u2013179 (2019).","journal-title":"Indian J. Med. Res."},{"issue":"4","key":"84293_CR13","doi-asserted-by":"publisher","first-page":"438","DOI":"10.4103\/0019-509X.175311","volume":"51","author":"N Thacker","year":"2014","unstructured":"Thacker, N. et al. Epidemiology of blood stream infections in pediatric patients at a Tertiary Care Cancer Centre. Indian J. Cancer. 51(4), 438\u2013441 (2014).","journal-title":"Indian J. Cancer."},{"issue":"4","key":"84293_CR14","doi-asserted-by":"publisher","first-page":"264","DOI":"10.4103\/JLP.JLP_149_16","volume":"9","author":"V Patwardhan","year":"2017","unstructured":"Patwardhan, V., Kumar, D., Goel, V. & Singh, S. Changing prevalence and antibiotic drug resistance pattern of pathogens seen in community-acquired pediatric urinary tract infections at a tertiary care hospital of North India. J. Lab. Physicians. 9(4), 264\u2013268 (2017).","journal-title":"J. Lab. Physicians."},{"issue":"1","key":"84293_CR15","doi-asserted-by":"publisher","first-page":"32","DOI":"10.4103\/ijmm.IJMM_17_415","volume":"36","author":"B Veeraraghavan","year":"2018","unstructured":"Veeraraghavan, B. et al. Antimicrobial susceptibility profiles of gram-negative bacteria causing infections collected across India during 2014\u20132016: Study for monitoring antimicrobial resistance trend report. Indian J. Med. Microbiol. 36(1), 32\u201336 (2018).","journal-title":"Indian J. Med. Microbiol."},{"key":"84293_CR16","unstructured":"CLSI-M100-24-2014. Performance Standards for Antimicrobial Susceptibility Testing (M100). 24th ed. The Clinical Laboratory Standards Institute 2014. https:\/\/clsi.org\/standards\/products\/microbiology\/documents\/m100\/. Accessed 12 Dec 2020."},{"key":"84293_CR17","unstructured":"CLSI-M100-25-2015. Performance Standards for Antimicrobial Susceptibility Testing (M100). 25th ed. The Clinical Laboratory Standards Institute 2015. https:\/\/clsi.org\/standards\/products\/microbiology\/documents\/m100\/. Accessed 12 Dec 2020."},{"key":"84293_CR18","unstructured":"CLSI-M100-26-2016. Performance Standards for Antimicrobial Susceptibility Testing (M100). 26th ed. The Clinical Laboratory Standards Institute 2016. https:\/\/clsi.org\/standards\/products\/microbiology\/documents\/m100\/. Accessed 12 Dec 2020."},{"key":"84293_CR19","unstructured":"CLSI-M100-27-2017. Performance Standards for Antimicrobial Susceptibility Testing (M100). 27th ed. The Clinical Laboratory Standards Institute 2017. https:\/\/clsi.org\/standards\/products\/microbiology\/documents\/m100\/. Accessed 12 Dec 2020."},{"key":"84293_CR20","unstructured":"CLSI-M100-28-2018. Performance Standards for Antimicrobial Susceptibility Testing (M100). 28th ed. The Clinical Laboratory Standards Institute 2018. https:\/\/clsi.org\/standards\/products\/microbiology\/documents\/. Accessed 9 Mar 2020."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-84293-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-84293-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-84293-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T23:42:34Z","timestamp":1670024554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-84293-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,4]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["84293"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-84293-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,4]]},"assertion":[{"value":"19 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5116"}}