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The behavior of residual tumors was analyzed for 111 patients who underwent surgery for newly diagnosed VS between September 2006 and July 2017. The postoperative tumor volume changes were assessed during a mean follow-up of 69\u00a0months (range 36\u2013147\u00a0months). Fifty-three patients underwent imaging surveillance following incomplete resection. There was no residual tumor growth in 44 patients (83%). A significant regression of residual tumor volume was noted in the no growth group at postoperative 1\u00a0year (p\u2009=\u20090.028), 2\u00a0years (p\u2009=\u20090.012), but not from 3\u00a0years onwards. Significant predictors of regrowth were immediate postoperative tumor volume\u2009\u2265\u20090.7 cm<jats:sup>3<\/jats:sup> (HR 10.5, p\u2009=\u20090.020) and residual tumor location other than the internal auditory canal (IAC) (HR 6.2, p\u2009=\u20090.026). The mean time to regrowth was 33\u00a0months (range 5\u2013127\u00a0months). The 2-, 5-, and 10-year regrowth-free survival rates were 90.6%, 86.8%, and 83%, respectively. In conclusion, significant residual tumor regression could occur within 2\u00a0years for a VS with an immediate postoperative tumor volume less than 0.7 cm<jats:sup>3<\/jats:sup> or residual tumor in IAC.<\/jats:p>","DOI":"10.1038\/s41598-021-84319-1","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T11:04:11Z","timestamp":1614251051000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas"],"prefix":"10.1038","volume":"11","author":[{"given":"Hun Ho","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong-Cheol","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Ho","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hee","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Sung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Seok","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Ki","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"key":"84319_CR1","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1097\/MAO.0b013e31827de2ec","volume":"34","author":"PM Spielmann","year":"2013","unstructured":"Spielmann, P. 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