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Fourteen patients with sarcoidosis (mean age, 46.0\u2009\u00b1\u20099.6\u00a0years) were examined before and after 3-week of ET programme in hospital settings. Symptoms (fatigue: FAS, dyspnoea: MRC), lung function tests and physical function tests (6 MWT, muscle force) were measured before and after ET. Proton nuclear magnetic resonance (NMR) spectroscopy combined with orthogonal partial least squares-discriminant analysis (OPLS-DA) was used to determine lipid profile before and after ET. Twenty-five NMR signals from lipid compounds were selected for further analysis as well as serum lipid and inflammatory markers. Three weeks of ET results in improvement of symptoms (FAS: 27.5 vs. 21.0; p\u2009&lt;\u20090.001, MRC: 0.86 vs. 0.14; p\u2009=\u20090.002) and physical function (6MWT: 508.43 vs. 547.29; p\u2009=\u20090.039). OPLS-DA analysis of the lipid profiles of patients with sarcoidosis revealed differences among the samples before and after ET, including decreases in fatty acids (p\u2009&lt;\u20090.017), triglycerides (p\u2009&lt;\u20090.022) and total cholesterol (p\u2009&lt;\u20090.020). Other changes included shifts in fatty acids oxidation products and triacylglycerol esters. A short-time, in-hospital exercise training benefits patients with sarcoidosis by enhancing their physical function. Additionally, positive effect on lipid profile was observed also in this study. 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