{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:12:41Z","timestamp":1791573161153,"version":"4.3.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this study, we evaluated the effectiveness of palliative breast radiation therapy (RT), with single fraction RT compared with fractionated RT. Our study showed that both RT fractionation schemas provide palliation. Single fraction RT allowed for treatment with minimal interference with systemic therapy, whereas fractionated RT provided a more durable palliative response. Due to equivalent palliative response, at our institution we have increasingly been providing single fraction RT palliation during the COVID-19 pandemic.<\/jats:p>","DOI":"10.1038\/s41598-021-84872-9","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T06:03:22Z","timestamp":1614924202000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Palliative radiation therapy for symptomatic advance breast cancer"],"prefix":"10.1038","volume":"11","author":[{"given":"Galia","family":"Jacobson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orit","family":"Kaidar-Person","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ory","family":"Haisraely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira","family":"Galper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Rabin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilanit","family":"Dromi Shahadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaacov Richard","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zvi","family":"Symon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merav","family":"Akiva Ben-David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"84872_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21332","volume":"66","author":"RL Siegel","year":"2016","unstructured":"Siegel, R. L., Miller, K. D. & Jemal, A. Cancer statistics, 2016. CA Cancer J. Clin. 66, 7\u201330 (2016).","journal-title":"CA Cancer J. Clin."},{"key":"84872_CR2","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.jpainsymman.2008.01.009","volume":"37","author":"V Maida","year":"2009","unstructured":"Maida, V., Ennis, M., Kuziemsky, C. & Trozzolo, L. Symptoms associated with malignant wounds: a prospective case series. J. Pain Symptom Manag. 37, 206\u2013211 (2009).","journal-title":"J. Pain Symptom Manag."},{"key":"84872_CR3","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s12032-017-1003-5","volume":"34","author":"O Kaidar-Person","year":"2017","unstructured":"Kaidar-Person, O. et al. The use of psychological supportive care services and psychotropic drugs in patients with early-stage breast cancer: a comparison between two institutions on two continents. Med. Oncol. 34, 144 (2017).","journal-title":"Med. Oncol."},{"key":"84872_CR4","first-page":"80","volume":"32","author":"M Ben-David","year":"2010","unstructured":"Ben-David, M. Fungating breast lesions in locally advanced breast cancer-physical and psychosocial aspects. J. Pediatr. Hematol. Oncol. 32, 80\u201382 (2010).","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"84872_CR5","doi-asserted-by":"publisher","first-page":"433","DOI":"10.6004\/jnccn.2017.0044","volume":"15","author":"WJ Gradishar","year":"2017","unstructured":"Gradishar, W. J. et al. NCCN guidelines insights: breast cancer, version 1.2017. J. Natl. Compr. Cancer Netw. 15, 433\u2013451 (2017).","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"84872_CR6","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.1200\/JCO.2014.55.1143","volume":"32","author":"ST Lutz","year":"2014","unstructured":"Lutz, S. T., Jones, J. & Chow, E. Role of radiation therapy in palliative care of the patient with cancer. J. Clin. Oncol. 32, 2913 (2014).","journal-title":"J. Clin. Oncol."},{"key":"84872_CR7","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.ijrobp.2016.08.017","volume":"97","author":"PT Truong","year":"2017","unstructured":"Truong, P. T. Local treatment of the primary tumor in patients presenting with stage IV breast cancer: a first, and what\u2019s up ahead. Int. J. Radiat. Oncol. Biol. Phys. 97, 443\u2013446 (2017).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"84872_CR8","first-page":"204, 206, 208 p","volume":"9","author":"K Fairbairn","year":"1993","unstructured":"Fairbairn, K. Towards better care for women. Understanding fungating breast lesions. Prof. Nurse Lond. Engl. 9, 204, 206, 208 passim (1993).","journal-title":"Prof. Nurse Lond. Engl."},{"key":"84872_CR9","first-page":"272","volume":"9","author":"K Fairbairn","year":"1994","unstructured":"Fairbairn, K. A challenge that requires further research. Management of fungating breast lesions. Prof. Nurse Lond. Engl. 9, 272 (1994).","journal-title":"Prof. Nurse Lond. Engl."},{"key":"84872_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13014-018-1191-y","volume":"14","author":"HS Choi","year":"2019","unstructured":"Choi, H. S., Jang, H. S., Kang, K. M. & Choi, B.-O. Symptom palliation of hypofractionated radiotherapy for patients with incurable inflammatory breast cancer. Radiat. Oncol. 14, 1\u20136 (2019).","journal-title":"Radiat. Oncol."},{"key":"84872_CR11","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.jaad.2012.02.010","volume":"67","author":"AP Chen","year":"2012","unstructured":"Chen, A. P. et al. Grading dermatologic adverse events of cancer treatments: the common terminology criteria for adverse events version 4.0. J. Am. Acad. Dermatol. 67, 1025\u20131039 (2012).","journal-title":"J. Am. Acad. Dermatol."},{"key":"84872_CR12","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.33.29_suppl.199","volume-title":"Palliation of Ulcerative Breast Lesions with Radiation","author":"P Vempati","year":"2015","unstructured":"Vempati, P. et al. Palliation of Ulcerative Breast Lesions with Radiation (American Society of Clinical Oncology, 2015)."},{"key":"84872_CR13","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1159\/000343041","volume":"5","author":"C Heese","year":"2012","unstructured":"Heese, C., Lavagnini, P., Mills, P., Lewis, M. & Markman, M. Superficial hyperthermia plus external beam radiation in the palliation of locally progressive chemoradiation-resistant breast cancer. Case Rep. Oncol. 5, 520\u2013523 (2012).","journal-title":"Case Rep. Oncol."},{"key":"84872_CR14","first-page":"e1360","volume":"9","author":"RW Gao","year":"2017","unstructured":"Gao, R. W., Edlund, S. & Yuan, J. Dramatic regression of a fungating breast lesion treated with radiation therapy. Cureus 9, e1360 (2017).","journal-title":"Cureus"},{"key":"84872_CR15","first-page":"e1417","volume":"9","author":"K Quackenbush","year":"2017","unstructured":"Quackenbush, K., Amini, A., Fisher, C. M. & Rabinovitch, R. Regression of a fungating tumor after hypofractionated radiation therapy in a patient with metastatic breast cancer. Cureus 9, e1417 (2017).","journal-title":"Cureus"},{"key":"84872_CR16","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1586\/era.11.168","volume":"11","author":"DH Nguyen","year":"2011","unstructured":"Nguyen, D. H. & Truong, P. T. A debate on locoregional treatment of the primary tumor in patients presenting with stage IV breast cancer. Expert Rev. Anticancer Ther. 11, 1913\u20131922 (2011).","journal-title":"Expert Rev. Anticancer Ther."},{"key":"84872_CR17","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1067\/msy.2002.127544","volume":"132","author":"SA Khan","year":"2002","unstructured":"Khan, S. A., Stewart, A. K. & Morrow, M. Does aggressive local therapy improve survival in metastatic breast cancer?. Surgery 132, 620\u2013627 (2002).","journal-title":"Surgery"},{"key":"84872_CR18","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s10549-009-0610-z","volume":"119","author":"BH Ly","year":"2010","unstructured":"Ly, B. H., Nguyen, N. P., Vinh-Hung, V., Rapiti, E. & Vlastos, G. Loco-regional treatment in metastatic breast cancer patients: is there a survival benefit?. Breast Cancer Res. Treat. 119, 537\u2013545 (2010).","journal-title":"Breast Cancer Res. Treat."},{"key":"84872_CR19","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1200\/JCO.2008.19.5396","volume":"27","author":"R Le Scodan","year":"2009","unstructured":"Le Scodan, R. et al. Breast cancer with synchronous metastases: survival impact of exclusive locoregional radiotherapy. J. Clin. Oncol. 27, 1375\u20131381 (2009).","journal-title":"J. Clin. Oncol."},{"key":"84872_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13014-019-1448-0","volume":"14","author":"R Kinj","year":"2019","unstructured":"Kinj, R. et al. Five-year oncological outcome after a single fraction of accelerated partial breast irradiation in the elderly. Radiat. Oncol. 14, 1\u20136 (2019).","journal-title":"Radiat. Oncol."},{"key":"84872_CR21","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.clon.2020.03.006","volume":"32","author":"C Coles","year":"2020","unstructured":"Coles, C. et al. International guidelines on radiation therapy for breast cancer during the COVID-19 pandemic. Clin. Oncol. 32, 279\u2013281 (2020).","journal-title":"Clin. Oncol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-84872-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-84872-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-84872-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T23:39:51Z","timestamp":1670024391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-84872-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["84872"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-84872-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,5]]},"assertion":[{"value":"3 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5282"}}