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A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography with enhanced depth imaging for measurement of SFCT and fundus photography. Blood pressure, fundus photographs and choroidal OCT-images were available for 3237 (93.3%) subjects, with 1953 (56.3\u2009\u00b1\u20090.8%) of the study population fulfilled the diagnosis of hypertension and 1089 subjects having hypertensive retinopathy. For the hypertensive cases, the SFCT in patients with hypertensive retinopathy (286.48\u2009\u00b1\u2009105.23\u00a0\u00b5m) was significantly thicker than subjects without hypertensive retinopathy (187.04\u2009\u00b1\u200978.80\u00a0\u00b5m, P\u2009&lt;\u20090.001). SFCT was significantly associated with the stage of hypertensive retinopathy (P\u2009&lt;\u20090.001), but not significantly associated with diastolic blood pressure (P\u2009=\u20090.94), history (P\u2009=\u20090.95) and years (P\u2009=\u20090.91) of hypertension. In conclusion, hypertension as systemic disease was not significantly affect the subfoveal choroidal thickness, but as ocular disease, hypertensive retinopathy was significantly related to changes of choroidal thickness. Lesions of choroid during chronic hypertension may play an important role in development of hypertensive retinopathy.<\/jats:p>","DOI":"10.1038\/s41598-021-84947-7","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T11:03:14Z","timestamp":1615287794000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The relationship between Subfoveal Choroidal Thickness and Hypertensive Retinopathy"],"prefix":"10.1038","volume":"11","author":[{"given":"Lei","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling Xiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Bin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"84947_CR1","doi-asserted-by":"publisher","first-page":"e65938","DOI":"10.1371\/journal.pone.0065938","volume":"8","author":"Y Gao","year":"2013","unstructured":"Gao, Y. et al. 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