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Amyloid-\u03b2 is a product of the chromosome 21 gene\n                    <jats:italic>APP<\/jats:italic>\n                    (amyloid precursor protein) and the extra copy or \u2018dose\u2019 of\n                    <jats:italic>APP<\/jats:italic>\n                    is thought to be the cause of this early-onset Alzheimer\u2019s disease. However, other chromosome 21 genes likely modulate disease when in three-copies in people with Down syndrome. Here we show that an extra copy of chromosome 21 genes, other than\n                    <jats:italic>APP<\/jats:italic>\n                    , influences APP\/A\u03b2 biology. We crossed Down syndrome mouse models with partial trisomies, to an\n                    <jats:italic>APP<\/jats:italic>\n                    transgenic model and found that extra copies of subgroups of chromosome 21 gene(s) modulate amyloid-\u03b2 aggregation and\n                    <jats:italic>APP<\/jats:italic>\n                    transgene-associated mortality, independently of changing amyloid precursor protein abundance. Thus, genes on chromosome 21, other than\n                    <jats:italic>APP,<\/jats:italic>\n                    likely modulate Alzheimer\u2019s disease in people who have Down syndrome.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-85062-3","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T06:03:49Z","timestamp":1615442629000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Genetic dissection of down syndrome-associated alterations in APP\/amyloid-\u03b2 biology using mouse models"],"prefix":"10.1038","volume":"11","author":[{"given":"Justin L.","family":"Tosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena R.","family":"Rhymes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Mumford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather T.","family":"Whittaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Pulford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue J.","family":"Noy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Cleverley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"LonDownS Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Strydom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Wiseman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Nizetic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Tybulewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Karmiloff-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L. 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