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Whether or not diabetic choroidopathy (DC) is involved in the initiation and progression of diabetic ocular complications needs to be explored. We included 54 diabetic eyes from 36 diabetic patients, and 54 healthy eyes from 32 control subjects after propensity scores matching. All of the subjects were given pupil light and dark adaptation examination and optical coherence tomography angiography (OCTA). Scotopic pupil diameter (SPD), pupil contraction\u00a0amplitude, and\u00a0velocity of pupil contraction of the diabetic group were significantly lower than that of the healthy control group (P\u2009&lt;\u20090.05).Choroidal thickness at temporal quadrant (at 750\u00a0\u03bcm) and superior quadrant (at 1500\u00a0\u03bcm and 2250\u00a0\u03bcm) increased in diabetic group compared to control group(P\u2009&lt;\u20090.05).In the diabetic group, choriocapillaris blood flow signal density (CCBFSD) in the macular area (diameter\u2009=\u20092000\u00a0\u03bcm) were significantly decreased compared with the healthy control group (P\u2009&lt;\u20090.05). Apparent changes in pupil and choroidal blood flow were observed in the diabetic patients.<\/jats:p>","DOI":"10.1038\/s41598-021-85065-0","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T11:03:49Z","timestamp":1615460629000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Higher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics"],"prefix":"10.1038","volume":"11","author":[{"given":"Yaoli","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaishuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"85065_CR1","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/S0161-6420(98)96025-0","volume":"105","author":"SE Moss","year":"1998","unstructured":"Moss, S. 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