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Retrospective, observational study. Medical and imaging records of patients that developed tears after starting anti-VEGF treatment and with at least 12\u00a0months of follow-up were reviewed. OCT reflectivity of the RPE-subretinal hyperreflective tissue (SHT) complex was measured at 6, 12 and 18\u00a0months (when available). Reflectivity of the adjacent unaffected RPE-Bruch\u2019s membrane was taken as internal reference. Other variables: grade and rip occurrence (early\/late); number of intravitreal injections; type of macular neovascularization; sub-macular hemorrhage (SMH) at onset. Forty-nine eyes (age: 76.1\u2009\u00b1\u20097.0\u00a0years; VA: 0.54\u2009\u00b1\u20090.27 LogMAR) were included. Thirty-eight eyes had OCT signs of healing during the follow-up, with 21 showing SMH at baseline. Final VA positively correlated with the number of injections and negatively correlated with the RPE-SHT reflectivity and the presence of SMH (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Reflectivity of the RPE-SHT complex was positively associated with time and SMH at baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In our study, most eyes showed signs of tissue repair after RPE tear. The reflectivity of repair tissue, the SMH presence and the number of anti-VEGF injections appeared to be major predictors of visual outcomes.<\/jats:p>","DOI":"10.1038\/s41598-021-85270-x","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T11:24:46Z","timestamp":1615893886000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Optical coherence tomography features of the repair tissue following RPE tear and their correlation with visual outcomes"],"prefix":"10.1038","volume":"11","author":[{"given":"Francesco","family":"Romano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Parrulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Battaglia Parodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Lupidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Cereda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Staurenghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Invernizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"85270_CR1","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1136\/bjo.68.8.513","volume":"68","author":"JDM Gass","year":"1984","unstructured":"Gass, J. 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