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We retrospectively compared childhood refractive error and ocular biometric features of fibroblast growth factor receptor (FGFR)-related syndromic craniosynostosis patients with those of non-syndromic craniosynostosis and control subjects. Thirty-six eyes (18 patients) with FGFR-related syndromic craniosynostosis, 76 eyes (38 patients) with non-syndromic craniosynostosis, and 114 eyes (57 patients) of intermittent exotropes were included in the analysis. Mean age at examination was 7.82\u2009\u00b1\u20092.51 (range, 4\u201316) years and mean spherical equivalent was -0.09\u2009\u00b1\u20091.46 Diopter. Mean age and refractive error were not different between groups, but syndromic craniosynostosis patients had significantly longer axial length, lower corneal power, and lower lens power than other groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01, and <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01, respectively). Axial length was positively correlated and keratometry and lens power were negatively correlated with age in non-syndromic craniosynostosis and controls, while these correlations between age and ocular biometric parameters were not present in the FGFR-related syndromic craniosynostosis. In conclusion, ocular biometric parameters in FGFR-related syndromic craniosynostosis differed from those of non-syndromic craniosynostosis and age-matched controls, and did not show the relations with age, suggesting this cohort may have abnormal refractive growth.<\/jats:p>","DOI":"10.1038\/s41598-021-85620-9","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T11:03:33Z","timestamp":1615979013000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis"],"prefix":"10.1038","volume":"11","author":[{"given":"Byung Joo","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kihwang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Ah","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Taek","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"85620_CR1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/j.1601-6343.2007.00393.x","volume":"10","author":"SA Boyadjiev","year":"2007","unstructured":"Boyadjiev, S. 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