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For all patients, age, sex, comorbidities, stone location, laboratory examination and geographic region were collected. The most common stone component was calcium oxalate (77.5%), followed by calcium phosphate (8.7%), infection stone (7.6%), uric acid (UA) stone (5.3%)and cystine (0.9%). The males had more calcium oxalate stones (p\u2009&lt;\u20090.001), while infection stone and cystine stones occurred more frequently in females (p\u2009&lt;\u20090.001). The prevalence peak occurred at 41\u201360\u00a0years in both men and women. UA stones occurred frequently in patients with lower urinary pH (p\u2009&lt;\u20090.001), while neutral urine or alkaline urine (p\u2009&lt;\u20090.001) and urinary infection (p\u2009&lt;\u20090.001) were more likely to be associated with infection stone stones. Patients with high levels of serum creatinine were more likely to develop UA stones (p\u2009&lt;\u20090.001). The proportion of UA stones in diabetics was higher (p\u2009&lt;\u20090.001), and the incidence of hypertension was higher in patients with UA stones (p\u2009&lt;\u20090.001). Compared to the other types, more calcium oxalate stones were detected in the kidneys and ureters (p\u2009&lt;\u20090.001), whereas struvite stones were more frequently observed in the lower urinary tract (p\u2009=\u20090.001). There was no significant difference in stone composition across the Qinling-Huaihe line in central China except UA stones, which were more frequently observed in patients south of the line (p\u2009&lt;\u20090.001).<\/jats:p>","DOI":"10.1038\/s41598-021-85723-3","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T13:04:20Z","timestamp":1616159060000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Urinary stone composition analysis and clinical characterization of 1520 patients in central China"],"prefix":"10.1038","volume":"11","author":[{"given":"Daling","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengguo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhankui","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"85723_CR1","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/bju.13828","volume":"120","author":"G Zeng","year":"2017","unstructured":"Zeng, G. et al. 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