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It is often associated with pre-existing hearing loss or noise-induced damage to the auditory system. In some individuals it occurs frequently or even continuously and leads to considerable distress and difficulty sleeping. There is little knowledge of the molecular mechanisms involved in tinnitus which has hindered the development of treatments. Evidence suggests that tinnitus has a heritable component although previous genetic studies have not established specific risk factors. From a total of 172,608 UK Biobank participants who answered questions on tinnitus we performed a case\u2013control genome-wide association study for self-reported tinnitus. Final sample size used in association analysis was N\u2009=\u200991,424. Three variants in close proximity to the\n                    <jats:italic>RCOR1<\/jats:italic>\n                    gene reached genome wide significance: rs4906228 (p\u2009=\u20091.7E\u221208), rs4900545 (p\u2009=\u20091.8E\u221208) and 14:103042287_CT_C (p\u2009=\u20093.50E\u221208).\n                    <jats:italic>RCOR1<\/jats:italic>\n                    encodes REST Corepressor 1, a component of a co-repressor complex involved in repressing neuronal gene expression in non-neuronal cells. Eleven other independent genetic loci reached a suggestive significance threshold of p\u2009&lt;\u20091E\u221206.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-85871-6","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T09:04:20Z","timestamp":1616144660000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank"],"prefix":"10.1038","volume":"11","author":[{"given":"Helena R. R.","family":"Wells","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatin N. 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Lancet 382, 1600\u20131607. https:\/\/doi.org\/10.1016\/S0140-6736(13)60142-7 (2013).","journal-title":"Lancet"},{"key":"85871_CR2","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1001\/jamaoto.2016.1700","volume":"142","author":"JM Bhatt","year":"2016","unstructured":"Bhatt, J. M., Lin, H. W. & Bhattacharyya, N. Prevalence, Severity, exposures, and treatment patterns of tinnitus in the United States. JAMA Otolaryngol. Head Neck Surg. 142, 959\u2013965. https:\/\/doi.org\/10.1001\/jamaoto.2016.1700 (2016).","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"85871_CR3","first-page":"1","volume-title":"Epidemiology of Tinnitus","author":"A Davis","year":"2000","unstructured":"Davis, A. & Refaie, A. E. Epidemiology of Tinnitus 1\u201323 (Thomson Learning, 2000)."},{"key":"85871_CR4","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1682\/jrrd.2010.07.0138","volume":"48","author":"RL Folmer","year":"2011","unstructured":"Folmer, R. L., McMillan, G. 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