{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:19:52Z","timestamp":1789057192401,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"TERUMO LIFE SCIENCE FOUNDATION"},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20fk0108086j0202"],"award-info":[{"award-number":["20fk0108086j0202"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19gm0910005j0005"],"award-info":[{"award-number":["JP19gm0910005j0005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17H04003"],"award-info":[{"award-number":["JP17H04003"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polio or poliomyelitis is a disabling and life-threatening disease caused by poliovirus (PV). As a consequence of global polio vaccination efforts, wild PV serotypes 2 and 3 have been eradicated around the world, and wild PV serotype 1-transmitted cases have been largely eliminated except for limited regions. However, vaccine-derived PV, pathogenically reverted live PV vaccine strains, has become a serious issue. For the global eradication of polio, the World Health Organization is conducting the third edition of the Global Action Plan, which is requesting stringent control of potentially PV-infected materials. To facilitate the mission, we generated a PV-nonsusceptible Vero cell subline, which may serve as an ideal replacement of standard Vero cells to isolate emerging\/re-emerging viruses without the risk of generating PV-infected materials.<\/jats:p>","DOI":"10.1038\/s41598-021-86050-3","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T07:04:07Z","timestamp":1616569447000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan"],"prefix":"10.1038","volume":"11","author":[{"given":"Yuko","family":"Okemoto-Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Someya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Yamaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Hanada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"86050_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0966-842x(94)90125-2","volume":"2","author":"A Nomoto","year":"1994","unstructured":"Nomoto, A., Koike, S. & Aoki, J. Tissue tropism and species specificity of poliovirus infection. Trends Microbiol. 2, 47\u201351. https:\/\/doi.org\/10.1016\/0966-842x(94)90125-2 (1994).","journal-title":"Trends Microbiol."},{"issue":"2","key":"86050_CR2","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1186\/s12889-020-09198-z","volume":"20","author":"O Alonge","year":"2020","unstructured":"Alonge, O. What can over 30 years of efforts to eradicate polio teach us about global health?. BMC Public Health 20(2), 1177. https:\/\/doi.org\/10.1186\/s12889-020-09198-z (2020).","journal-title":"BMC Public Health"},{"key":"86050_CR3","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/j.vaccine.2018.02.059","volume":"36","author":"M Shaghaghi","year":"2018","unstructured":"Shaghaghi, M. et al. New insights into physiopathology of immunodeficiency-associated vaccine-derived poliovirus infection; systematic review of over 5 decades of data. Vaccine 36, 1711\u20131719. https:\/\/doi.org\/10.1016\/j.vaccine.2018.02.059 (2018).","journal-title":"Vaccine"},{"key":"86050_CR4","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1126\/science.aba1238","volume":"368","author":"GR Macklin","year":"2020","unstructured":"Macklin, G. R. et al. Evolving epidemiology of poliovirus serotype 2 following withdrawal of the serotype 2 oral poliovirus vaccine. Science 368, 401\u2013405. https:\/\/doi.org\/10.1126\/science.aba1238 (2020).","journal-title":"Science"},{"key":"86050_CR5","volume-title":"WHO Global Action Plan to Minimize Poliovirus Facility-Associated Risk After Type-Specific Eradication of Wild Polioviruses and Sequential Cessation of Oral Polio Vaccine Use","author":"The World Health Organization","year":"2015","unstructured":"The World Health Organization. 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